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Abstracts tagged "immune deficiency"

  • Abstract Number: 762 • ACR/ARHP Annual Meeting 2016

    Pragmatic Treatment of Patients with Systemic Lupus Erythematosus with Rituximab: Long-Term Effects on Serum Immunoglobulins

    Venkat Reddy1, Lina Martínez-Estupiñán2, David A. Isenberg3, Maria J. Leandro3 and Geraldine Cambridge3, 1Rheumatology, University College Hospital, London, United Kingdom, 2Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: B cell depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with Systemic Lupus Erythematosus (SLE). Hypogammaglobulinemia can be…
  • Abstract Number: 2117 • ACR/ARHP Annual Meeting 2016

    B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab

    Geraldine Cambridge1, Rita A. Moura2, Venkat Reddy3 and Maria J. Leandro1, 1Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 2Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, 3Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom

    Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
  • Abstract Number: 760 • ACR/ARHP Annual Meeting 2016

    Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE

    Geoffrey Stephens1, Rong Zeng2, Xiang Guo2, Steve Eck3, Yuling Wu3, Liangwei Wang3, Gabor Illei3 and Wendy White2, 1Cellcion, Clarksburg, MD, 2Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 3MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…
  • Abstract Number: 539 • ACR/ARHP Annual Meeting 2015

    Quantification of T-Cell Receptor Excision Circles (TREC) from Peripheral Blood in Patients with Inflammatory Polyarthritis of Recent Onset (EPA): Association with Radiographic Joint Damage

    Alexandre Osborne1, Nathalie Carrier2, Artur J de Brum-Fernandes3, Patrick Liang3, Ariel Masetto4 and Gilles Boire3, 1Clinical Sciences Program, Université de Sherbrooke, Sherbrooke, QC, Canada, 2Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 3Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 4Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada

    Background/Purpose: Patients with established Rheumatoid arthritis (RA) present evidence for an exhausted immune system. It is not known whether patients seen at the Early inflammatory…
  • Abstract Number: 2061 • ACR/ARHP Annual Meeting 2014

    Unexpectedly High Prevalence of Immunoglobulin Deficiency in Fibromyalgia

    Xavier Caro and Earl Winter, Fibromyalgia Research and Treatment Center, Northridge, CA

    Background/Purpose:   It has recently been shown that Fibromyalgia (FM) is commonly associated with clinical evidence of neuropathic pain language, laboratory evidence of small fiber…
  • Abstract Number: 2195 • ACR/ARHP Annual Meeting 2013

    Expanding The Spectrum Of Recombination Activating Gene-1 Deficiency To Include Early Onset Autoimmunity

    Lauren A. Henderson1, Francesco Frugoni1, Gregory Hopkins2, Helen de Boer2, Sung-Yun Pai2,3, Yu Nee Lee1, Jolan E. Walter4, Melissa M. Hazen1 and Luigi D Notarangelo5,6, 1Division of Immunology, Boston Children's Hospital, Boston, MA, 2Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, 3Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, 4Division of Allergy/Immunology, Massachusetts General Hospital for Children, Boston, MA, 5Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, 6Harvard Stem Cell Institute, Boston, MA

    Background/Purpose: We sought to identify the etiology of early onset autoimmunity and T cell lymphopenia in two siblings through genetic and functional studies.  Newborn screening…

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