Abstracts tagged "immune deficiency"

Abstract Number: 760 • 2016 ACR/ARHP Annual Meeting
Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE
Geoffrey Stephens¹, Rong Zeng², Xiang Guo², Steve Eck³, Yuling Wu³, Liangwei Wang³, Gabor Illei³ and Wendy White², ¹Cellcion, Clarksburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³MedImmune, LLC, Gaithersburg, MD
Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…
Abstract Number: 762 • 2016 ACR/ARHP Annual Meeting
Pragmatic Treatment of Patients with Systemic Lupus Erythematosus with Rituximab: Long-Term Effects on Serum Immunoglobulins
Venkat Reddy¹, Lina Martínez-Estupiñán², David A. Isenberg³, Maria J. Leandro³ and Geraldine Cambridge³, ¹Rheumatology, University College Hospital, London, United Kingdom, ²Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: B cell depletion therapy based on rituximab is a therapeutic option for refractory disease in patients with Systemic Lupus Erythematosus (SLE). Hypogammaglobulinemia can be…
Abstract Number: 2117 • 2016 ACR/ARHP Annual Meeting
B Cell Phenotype and in Vitro Function in Patients with Rheumatoid Arthritis Developing Low Serum Immunoglobulins after Multiple Cycles of Rituximab
Geraldine Cambridge¹, Rita A. Moura², Venkat Reddy³ and Maria J. Leandro¹, ¹Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, ²Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, Lisbon, Portugal, ³Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom
Background/Purpose: Repeat treatment with rituximab (RTX) predisposes some patients with rheumatoid arthritis (RA) to develop low levels of serum immunoglobulins (Igs). Understanding B cell function…
Abstract Number: 539 • 2015 ACR/ARHP Annual Meeting
Quantification of T-Cell Receptor Excision Circles (TREC) from Peripheral Blood in Patients with Inflammatory Polyarthritis of Recent Onset (EPA): Association with Radiographic Joint Damage
Alexandre Osborne¹, Nathalie Carrier², Artur J de Brum-Fernandes³, Patrick Liang³, Ariel Masetto⁴ and Gilles Boire³, ¹Clinical Sciences Program, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ³Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
Background/Purpose: Patients with established Rheumatoid arthritis (RA) present evidence for an exhausted immune system. It is not known whether patients seen at the Early inflammatory…
Abstract Number: 2061 • 2014 ACR/ARHP Annual Meeting
Unexpectedly High Prevalence of Immunoglobulin Deficiency in Fibromyalgia
Xavier Caro and Earl Winter, Fibromyalgia Research and Treatment Center, Northridge, CA
Background/Purpose: It has recently been shown that Fibromyalgia (FM) is commonly associated with clinical evidence of neuropathic pain language, laboratory evidence of small fiber…
Abstract Number: 2195 • 2013 ACR/ARHP Annual Meeting
Expanding The Spectrum Of Recombination Activating Gene-1 Deficiency To Include Early Onset Autoimmunity
Lauren A. Henderson¹, Francesco Frugoni¹, Gregory Hopkins², Helen de Boer², Sung-Yun Pai^2,3, Yu Nee Lee¹, Jolan E. Walter⁴, Melissa M. Hazen¹ and Luigi D Notarangelo^5,6, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, ³Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, ⁴Division of Allergy/Immunology, Massachusetts General Hospital for Children, Boston, MA, ⁵Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, ⁶Harvard Stem Cell Institute, Boston, MA
Background/Purpose: We sought to identify the etiology of early onset autoimmunity and T cell lymphopenia in two siblings through genetic and functional studies. Newborn screening…

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