ACR Meeting Abstracts

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Abstracts tagged "Immune checkpoint inhibitor"

  • Abstract Number: 0438 • ACR Convergence 2021

    Rheumatological Immune-Related Adverse Events of Immune Checkpoint Inhibitors Based on the FDA Adverse Event Reporting System

    Alicia Rodriguez-Pla, Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Immune checkpoint inhibitors (ICIs) provide effective treatment for many cancers but, presumably due to persistent activation of the immune system, they cause a variety…
  • Abstract Number: 1516 • ACR Convergence 2021

    Clinical Phenotypes and Treatment of Rheumatic Immune-Related Adverse Events from Checkpoint Inhibitors: A Retrospective Cohort of 112 Patients

    Tiphaine Lenfant1, Yuxuan Jin2, Elizabeth Kirchner3, Pauline Funchain2, Jung-Min Song2, Moshe Ornstein2, Laura Wood2, Donald Eicher2, Rula Hajj-Ali4, Leonard Calabrese2 and Cassandra Calabrese5, 1Institut Mutualiste Montsouris, Paris, France, 2Cleveland Clinic, Cleveland, OH, 3CCF, Cleveland, OH, 4Cleveland Clinic, Hunting Valley, OH, 5Cleveland Clinic Foundation, Cleveland Heights, OH

    Background/Purpose: To describe a single center cohort of rheumatic immune related adverse events (irAEs) observed in patients treated with checkpoint inhibitor therapy (ICI) and to…
  • Abstract Number: 1519 • ACR Convergence 2021

    Concomitant Targeted Therapy with Ongoing Immune Checkpoint Inhibitor (ICI) Therapy for Severe Immune Related Adverse Events (irAEs): Clinical Experience from Two Centers

    Cassandra Calabrese1, Khashayar Esfahani2 and Leonard Calabrese3, 1Cleveland Clinic Foundation, Cleveland Heights, OH, 2Jewish General Hospital, Department of Oncology, McGill University, Montréal, QC, Canada, 3Cleveland Clinic, Cleveland, OH

    Background/Purpose: Treatment of irAEs is a balance of suppressing irAE-associated hyper-inflammation without inhibiting anti-tumoral effects of ICI. Treatment of grade 3/4 irAEs is most challenging…
  • Abstract Number: 1520 • ACR Convergence 2021

    Do Specific Rheumatic Autoantibodies Predict Severity or Time to Onset of Immune-related Adverse Events from Checkpoint Inhibitors?

    Nilasha Ghosh1, Deanna Jannat-Khah2, Karmela Kim Chan2, Michael Postow3 and Anne Bass4, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Memorial Sloane Kettering Cancer Center, New York, NY, 4Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have had a dramatic impact on treating advanced malignancies by enhancing the anti-tumor T…
  • Abstract Number: 1521 • ACR Convergence 2021

    Autoantibody Microarray Signal Intensities May Predict the Occurrence of Immune-related Adverse Events

    Nilasha Ghosh1, Chengsong Zhu2, Karmela Kim Chan3, Michael Postow4 and Anne Bass5, 1Hospital for Special Surgery, New York, NY, 2UT Southwestern, Dallas, TX, 3Hospital for Special Surgery, New York, NY, 4Memorial Sloane Kettering Cancer Center, New York, NY, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: Immune checkpoint inhibitors (ICI) are a novel cancer therapeutic that have had a dramatic impact on treating advanced malignancies by enhancing the anti-tumor T…
  • Abstract Number: 1523 • ACR Convergence 2021

    Outcomes and Disease Characteristics in Patients with Rheumatoid Arthritis Treated with Immune Checkpoint Inhibitors for Malignancy at a Single Academic Institution

    Megan Hansen, Danny Zakria and Douglas Johnson, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Since the introduction of the first immune checkpoint inhibitor (ICI) in 2011, they have become widely utilized in the treatment of malignancy. It is…
  • Abstract Number: 2152 • 2019 ACR/ARP Annual Meeting

    Safety of Immune Checkpoint Inhibitors in Patients Treated for Cancer with Pre-existing Autoimmune Diseases

    Aneet Kaur 1, Umang Swami 1, Munazza Fatima 1, Meredith Ginn 1, Jill Stein 1, Yubo Gao 1, Yousef Zakharia 1 and Namrata Singh2, 1University of Iowa Hospitals and clinics, Iowa city, IA, 2University of Iowa, Iowa City

    Background/Purpose: Patients with pre-existing autoimmune diseases (AID) have been traditionally excluded from clinical trials of immune checkpoint inhibitors (ICI), so the data on risk of…
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