immune activation and mouse model Archives

Abstract Number: 1461 • ACR/ARHP Annual Meeting 2016
Modification of Proteins with Malondialdehyde-Acetaldehyde and Citrulline Elicit Antibody Responses in DBA/1J Mice
Peter M. Maloley¹, Michael J. Duryee², Carlos D. Hunter², James R. O'Dell³, Daniel R. Anderson¹, Ted R Mikuls⁴, Geoffrey M. Thiele¹ and Lynell W. Klassen³, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous studies have shown that proteins modified with malondialdehyde-acetaldehyde (MAA) and/or citrulline (CIT) co-localize in rheumatoid arthritis (RA) synovial tissues, are pro-inflammatory, and promote…

Abstracts tagged "immune activation and mouse model"