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Abstracts tagged "immune activation and B cells"

  • Abstract Number: 2558 • ACR/ARP Annual Meeting 2019

    Profiling of Gene Expression, Immune Cell Subtypes, and Circulating Protein Biomarkers in Systemic Lupus Erythematosus Patients Treated with the Selective Immunoproteasome Inhibitor, KZR-616

    R Andrea Fan1, Janet Anderl 1, Brian Tuch 2, Darrin Bomba 1, Niti Goel 3 and Christopher Kirk 1, 1Kezar Life Sciences, South San Francisco, CA, 2Kezar Life Sciences, south san francisco, 3Kezar Life Sciences, Duke University School of Medicine, South San Francisco, CA

    Background/Purpose: KZR-616 is a selective inhibitor of the immunoproteasome, the form of proteasome found predominantly in immune cells. In nonclinical studies, KZR-616 blocks acute production…
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