Abstracts tagged "imaging techniques and osteoarthritis"

Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting
Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study
Alan Brett¹, Michael A Bowes ¹, Philip G Conaghan ², Christoph Ladel ³, Jeffrey Kraines ⁴, Hans Guehring ³, Flavie Moreau ⁴ and Felix Eckstein ⁵, ¹Imorphics, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Paracelsus Medical University, Salzburg, Austria
Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
Abstract Number: 1190 • 2014 ACR/ARHP Annual Meeting
Osteoarthritis-like Changes Are Present in the Tibia and Femur 1 Year Following ACL Reconstruction
Valentina Pedoia¹, Drew A. Lansdown², Musa Zaid³, Charles McCulloch⁴, C. Benjamin Ma² and Xiaojuan Li⁵, ¹Department of Radiology & Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ²Department of Orthopedic Surgery, UCSF, San Francisco, CA, ³Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA, ⁴Department of Epidemiology and Biostatistics, San Francisco, CA, ⁵Department of Radiology and Biomedical Imaging, Musculoskeletal Quantitative Imaging Research, UCSF, San Francisco, CA
Background/Purpose Statistical Shape Modeling (SSM) is a promising tool that has the ability to characterize complex shapes in a brief feature vector. The application of…
Abstract Number: 271 • 2012 ACR/ARHP Annual Meeting
Bone Marrow Lesions in Knees with Osteoarthritis: Can Parameters From Dynamic Contrast Enhancement Predict Change in Bone Marrow Lesion Volume or Knee Pain Change?
Andrew D. Gait¹, Timothy F. Cootes¹, Elizabeth J. Marjanovic¹, Matthew J. Parkes², Charles E. Hutchinson³ and David T. Felson⁴, ¹Imaging Sciences, School of Cancer & Enabling Sciences, University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ³Warwick Medical School, University of Warwick, Coventry, United Kingdom, ⁴ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Dynamic contrast enhancement is a powerful tool for highlighting features of a medical image which may not otherwise be seen on "static" scans. While…
Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting
Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis
Brett A. Tonkin¹, Evange Romas², Natalie A. Sims¹ and Nicole C. Walsh¹, ¹St Vincent's Institute of Medical Research, Melbourne, Australia, ²Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia
Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…

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