ACR Meeting Abstracts

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Abstracts tagged "IL-6"

  • Abstract Number: 2508 • 2014 ACR/ARHP Annual Meeting

    Tocilizumab Serum Trough Levels and Its Relationship with Disease Activity and Drug Dosage in Rheumatoid Arthritis Patients

    Virginia Ruiz-Esquide1, Azucena Gonzalez-Navarro2, Jordi Yagüe3, Jose Inciarte-Mundo1, M. Victoria Hernández1, Julio Ramirez1, Sonia Cabrera-Villalba1, Juan D. Cañete1 and Raimon Sanmarti1, 1Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 2Immunology Department, Hospital Clinic of Barcelona, Barcelona, Spain, 3Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain

    Background/Purpose Tocilizumab (TCZ) is a humanized monoclonal antibody against interleukin-6 receptor used for the treatment of active rheumatoid arthritis (RA). The response to this treatment…
  • Abstract Number: 30 • 2014 ACR/ARHP Annual Meeting

    Inhibiting Autocrine Interleukin-6 (IL-6) Trans-Signalling in Human CD14+VE Monocultures Reduces Osteoclast Differentiation

    Lauren A. Jordan1, Fraser L. Collins2, Simon A. Jones1, Ernest H. Choy3, Ann K. Harvey1 and Anwen S. Williams1, 1Cardiff University, Institute of Infection and Immunity, School of Medicine, Cardiff, United Kingdom, 2Michigan State University, Department of Physiology, East Lansing, MI, 3Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, School of Medicine, Cardiff, United Kingdom

    Background/Purpose: Interleukin-6 (IL-6) and the inflammatory CC-chemokine CCL3 are highly expressed in rheumatoid arthritis, juvenile idiopathic arthritis and multiple myeloma. While these mediators contribute to…
  • Abstract Number: 2455 • 2014 ACR/ARHP Annual Meeting

    IL-6 Proximal Promoter SNP rs18000795 Genotype Strongly Correlates with Synovial Fibroblast IL-6 Expression

    Erika Noss1, Sook Kyung Chang2, Gerald Watts2 and Michael Brenner2, 1Divison of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose Interleukin (IL)-6 is an important driver of rheumatoid arthritis (RA) pathology, and synovial fibroblasts are a major source of IL-6 in the RA synovium. …
  • Abstract Number: 2464 • 2014 ACR/ARHP Annual Meeting

    Anti-Arthritic Effect of Tubastatin A, a Novel Histone Deacetylases-6 Inhibitor, Is Mediated By Stabilization of IkB Via Suppression of Ubiquitin-Proteasome Pathway

    Eun Chung Hong1, Hemin Jeong2, Jiwon Hwang2, Eun-Kyung Bae1, Hyungjin Kim2, Joong Kyong Ahn3, Hoon-Suk Cha2, Eun-mi Koh4 and Jaejoon Lee4, 1Samsung Biomedical Research Institute, Seoul, South Korea, 2Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 3Sungkyunkwan univ. school of medicine, Seoul, South Korea, 4Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: Histone deacetylase-6 (HDAC-6) functions as a non-epigenetic deacetylase for non-histone substrates and regulates microtubule-mediates processes such as cell migration, cell cycle arrest, and angiogenesis.…
  • Abstract Number: 2345 • 2014 ACR/ARHP Annual Meeting

    Anti-IL-6 Receptor Antibody Prevents Deterioration in Bone Structure in a Mouse Model of Collagen-Induced Arthritis

    Hiroto Yoshida, Mika Yagoto, Miho Suzuki, Keisuke Tanaka, Misato Hashizume and Yoshihiro Matsumoto, Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a disease that typically induces secondary osteoporosis, which increases the risk of bone fractures and, consequently, mortality. Bone fracture is…
  • Abstract Number: 1956 • 2014 ACR/ARHP Annual Meeting

    Increased IL-6 Production By Effector B Cells in Giant Cell Arteritis and Polymyalgia Rheumatica

    Kornelis S.M. van der Geest1, Wayel H. Abdulahad2, Gerda Horst3, Abraham Rutgers2, Annemieke M.H. Boots4 and Elisabeth Brouwer5, 1Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 3University Medical Center Groningen, Groningen, Netherlands, 4Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Hanzeplein 1, UMCG, Groningen, Netherlands

    Background/Purpose: The role of B cells in auto-immunity may extend beyond the production of auto-antibodies. B cells can influence T cell responses via antigen presentation…
  • Abstract Number: 1906 • 2014 ACR/ARHP Annual Meeting

    IL-6 Blockade Reduces Circulating N-Terminal Pro-Brain Natriuretic Peptide Levels in Patients with Active Rheumatoid Arthritis

    Atsuma Nishiwaki1, Hitomi Kobayashi2, Yasuyuki Kobayashi3, Isamu Yokoe1, Noboru Kitamura2, Hidetake Shiraiwa1, Takamasa Nozaki1, Hirotake Inomata2, Natsumi Ikumi4, Kaita Sugiyama1, Yousuke Nagasawa1 and Masami Takei5, 1Nihon University School of Medicine, Tokyo, Japan, 2Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 3Radiology, St.Marianna University School of Medicine, Kawasaki, Japan, 4Division of Heamatology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan, 5Dept of Med Rheumatology, Nihon University School of Medicine, Itabashi Tokyo, Japan

    Background/Purpose Patients with rheumatoid arthritis (RA) have a 1.5–2.0 fold higher risk of developing congestive heart failure (CHF) than the general population. Small increases in…
  • Abstract Number: 1714 • 2014 ACR/ARHP Annual Meeting

    IL-6 Trans-Signalling Activates M2 Macrophage Polarisation and Mediates Fibrotic Response in Scleroderma

    Rebecca Alade, Shiwen Xu, Korsa Khan, Angela Tam, Christopher P. Denton and Voon H. Ong, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom

    Background/Purpose IL6 is a key mediator in activation of extracellular matrix (ECM) in scleroderma (SSc) fibroblasts and via its interplay with chemokines may modulate mononuclear…
  • Abstract Number: 1621 • 2014 ACR/ARHP Annual Meeting

    A Shift Towards Trans-Signalling Explains Relatively Low CRP Despite an Active Interleukin-6 (IL-6)/IL-6-Receptor (IL-6R) System in SLE

    Martyna Skwarek, Babett Heschel, Julia Fantana and Martin Aringer, Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany

    Background/Purpose IL-6 has been found increased in SLE, while CRP, which is directly stimulated by IL-6, usually remains low. We therefore analyzed the IL-6/ IL-6…
  • Abstract Number: 1469 • 2014 ACR/ARHP Annual Meeting

    Methotrexate Treatment Reduces Serum IL-6 Level By Decreasing a CD14brightCD16+ Intermediate Non-Classical Subset of Monocytes in RA Patients

    Masako Tsukamoto1, Keiko Yoshimoto2, Noriyuki Seta3, Katsuya Suzuki2 and Tsutomu Takeuchi2, 1Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine, Keio university, Tokyo, Japan

    Background/Purpose It is well known that circulating monocytes are the source of inflammatory cytokines, such as IL-6 and TNFα and newly divided into three subsets…
  • Abstract Number: 1468 • 2014 ACR/ARHP Annual Meeting

    Mechanism of Effectiveness of IL-6 Blockade for Reduction of SAA Production and Amyloid a Deposition in AA Amyloidosis Patients with RA

    Kazuyuki Yoshizaki, Osaka University, Osaka, Japan

    Background/Purpose AA amyloidosis is a serious complication of chronic inflammatory and infectious diseases resulting from the deposition of amyloid A protein. Serum amyloid A (SAA),…
  • Abstract Number: 3001 • 2014 ACR/ARHP Annual Meeting

    Targeting IL-6 By Both Passive or Active Immunization Strategies Prevents Inflammation-Driven Skin Fibrosis

    Jerome Avouac1, Lucille Desallais2, Maxime Fréchet3, Muriel Elhai3, Jean François Zagury2 and Yannick Allanore1, 1Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, 2Chaire de Bioinformatique, Laboratoire Génomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et Métiers, Paris, France, 3INSERM U1016, Cochin Institute, Paris, France

    Background/Purpose: Interleukin 6 (IL-6) is a pleiotropic cytokine involved in inflammatory and autoimmune processes. Preliminary data have suggested that IL-6 might contribute to systemic sclerosis…
  • Abstract Number: 1015 • 2014 ACR/ARHP Annual Meeting

    Mir-9/MCPIP1 Axis Mediated Regulation of IL-6 Expression in Osteoarthritis Chondrocytes

    Tariq Haqqi1, Abdul Haseeb2 and Mohammad Shahidul Makki2, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH

    Background/Purpose Post-transcriptional regulation of cytokine expression is important for maintaining tissue integrity. MCPIP1 was identified as a novel protein, which destabilizes inflammatory cytokines mRNAs via…
  • Abstract Number: 1866 • 2013 ACR/ARHP Annual Meeting

    Primary Human Cell BioMAP® Profiling Of Methotrexate, Tocilizumab, Adalimumab, and Tofacitinib Reveals Different Mechanisms Of Action With Distinct Phenotypic Signatures

    Seng-Lai Tan1, Alison O'Mahony2, Ellen L. Berg2, Kandeepan Ganeshalingam3 and Ernest H. Choy4, 1Inflammation, Hoffmann-La Roche, Nutley, NJ, 2BioSeek, South San Francisco, CA, 3F. Hoffmann-La Roche, Basel, Switzerland, 4Cardiff University School of Medicine, Cardiff, United Kingdom

    Background/Purpose: Proinflammatory cytokines cause joint inflammation and destruction in patients with rheumatoid arthritis, as exemplified by the therapeutic success of inhibiting tumor necrosis factor alpha…
  • Abstract Number: 1833 • 2013 ACR/ARHP Annual Meeting

    Combination Of TNF and IL-6 Induces Osteoclast-Like Cells With Bone-Resorption Activity Both In Vitro and In Vivo

    Kazuhiro Yokota, Kojiro Sato and Toshihide Mimura, Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Although TNF inhibitors suppress bone destruction in patients with rheumatoid arthritis (RA), TNFα stimulation alone does not directly induce osteoclasts, bone-resorbing cells. With the…
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