Abstracts tagged "IL-6 and IL-6R signaling"

Abstract Number: 2385 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Antibody Clazakizumab Is More Potent Than Tocilizumab In Blocking In Vitro and Ex Vivo IL-6-Induced Functions
Q Zhao, J Pang, D Shuster, C Hung, S Baglino, R Dodge, H Sun, W Trigona and L Salter-Cid, Bristol-Myers Squibb Research and Development, Princeton, NJ
Background/Purpose: Interleukin-6 (IL-6), a pleiotropic cytokine, drives cell functions by binding to membrane-bound IL-6 receptor (IL-6R, classical signaling) or to soluble IL-6R (sIL-6R, trans-signaling) and…

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Abstracts tagged "IL-6 and IL-6R signaling"

Anti-IL-6 Antibody Clazakizumab Is More Potent Than Tocilizumab In Blocking In Vitro and Ex Vivo IL-6-Induced Functions