Abstracts tagged "IL-23"

Abstract Number: 2809 • 2015 ACR/ARHP Annual Meeting
Increased Frequencies of IL-23R Positive T Cells and IL-22 and IL-17 Producing MAIT Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis: Preliminary Results.
Eric Toussirot¹, Caroline Laheurte², Béatrice Gaugler³ and Philippe Saas⁴, ¹Service de Rhumatologie, CHU J Minjoz, Besancon, France, ²Etablissement Français du Sang/ Université de Franche Comté / CBT506 / CHRU, INSERM UMR1098 / Plateforme Biomonitoring, Besançon, France, ³EFS Bourgogne Franche Comté, INSERM UMR1098 / Etablissement Français du Sang / Université de Franche Comté, Besançon, France, ⁴Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Ankylosing spondylitis (AS) is the prototypic and most common form of spondyloarthritis (SpA). It was recently suggested that IL-23 could play a pivotal role…
Abstract Number: 2819 • 2015 ACR/ARHP Annual Meeting
Rorc Antagonism Inhibits IL-23-Dependent Aberrant Bone Formation in Vivo
Mark Panzenbeck¹, Kathleen Hoyt¹, Donald Souza², Gregg Davis¹, Elizabeth Glynn¹, Thomas Wieckowski¹, Michael Turner¹, Robert Hughes¹, Dustin Smith¹, Christian Harcken¹, Gerald Nabozny³ and Mark Labadia⁴, ¹Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Immunology & Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: RORγt is a nuclear hormone receptor expressed in Th17 cells and distinct subsets of lymphoid cells, including innate lymphoid cells (ILC), and γδ T-cells.…
Abstract Number: 2822 • 2015 ACR/ARHP Annual Meeting
Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis
Elizabeth Mainolfi¹, Susan M. Goodman², Shawn Anderson³, Jon Hill⁴, Thakker Paresh⁵, Meera Ramanujam⁶, Rivka Friedlander⁷, Elli Kim⁷, Dalit Ashany⁸, Ed Purdue⁹, Christine Averill⁹, Michael Nevid⁹, Allison Shaber⁹, Lisa Mandl¹⁰, Steven R. Goldring¹¹, Gerald Nabozny¹ and VP Bykerk², ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, ⁸Rheumatic Disease, Hospital for Special Surgery, New York, NY, ⁹Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, ¹⁰Department of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Hospital for Special Surgery, New York, NY
Background/Purpose: The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…
Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting
Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis
Nataliya Yeremenko¹, Raquel Celis², Leonie M. van Duivenvoorde³, Julio Ramirez⁴, Iris C. Blijdorp⁵, Sara Marsal⁶, Jose L. Pablos⁷, Raimon Sanmarti⁴, Juan D. Cañete⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…
Abstract Number: 806 • 2014 ACR/ARHP Annual Meeting
Association of a Single Nucleotide Polymorphism (SNP) in IL-12B Region with Clinical Features and Peripheral T Cell Profiles of Patients with Takayasu Arteritis
Toshiki Nakajima¹, Hajime Yoshifuji¹, Chikashi Terao², Koji Kitagori¹, Ran Nakashima¹, Yoshitaka Imura³, Naoichiro Yukawa¹, Koichiro Ohmura¹, Takao Fujii¹ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose We preliminarily found a SNP (A vs. C, rs6871626)　in IL-12B region　as a susceptibility gene to Takayasu arteritis (TAK) by genome-wide association study. IL-12Bencodes IL-12/IL-23…
Abstract Number: 632 • 2014 ACR/ARHP Annual Meeting
IL-23 Mediates Psoriasis-like Inflammation in the SKG Mouse Model of Spondyloarthropathy
Helen Benham¹, Linda Rehaume¹, Athan Baillet¹, Zaied Bhuyan¹, Jaclyn Bowman¹, Dimeng Pang¹, Kristine Kikly², Geoffrey Strutton³, Matthew Brown¹ and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ³Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia
Background/Purpose Psoriasis (Ps) is a common immune-mediated inflammatory skin disease and is a well- recognised extra-articular manifestation of the spondyloathopathies (SpA). Genetic studies implicate IL-23…
Abstract Number: 2409 • 2013 ACR/ARHP Annual Meeting
Association Of High Serum Interleukin-23 Levels With Porphyromonas Gingivalis Antibodies In Patients With Early Rheumatoid Arthritis
Sheila L. Arvikar¹, Klemen Strle², Deborah S. Collier³, Mark C. Fisher¹, Toshihisa Kawai⁴, Jose U. Scher⁵ and Allen C. Steere⁶, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Boston, MA, ⁴Forsyth Institute, Cambridge, MA, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁶Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased frequency of periodontal disease (PD) and antibodies to P. gingivalis (Pg), a major periodontal pathogen. Both…
Abstract Number: 1650 • 2013 ACR/ARHP Annual Meeting
The Route Of T Cell Priming Determines The Requirement For IL-23 In The Development Of Arthritis
Alison Finnegan¹, Yanxia Cao¹ and Susan Olalekan², ¹Dept of Medicine, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Rheumatoid arthritis is a very heterogeneous disease and distinct molecular mechanisms may underlie the disease process. IL-23 is an important cytokine for the expansion…
Abstract Number: 717 • 2013 ACR/ARHP Annual Meeting
Patients With Rheumatoid Arthritis Have Impaired Candida Albicans Specific Th17 Responses But Preserved Oral Candida Albicans Protective Immunity
Shrinivas Bishu¹, E. Wern Su², Erich Wikerson³, Donald M. Jones⁴, Kelly A. Reckley⁵, Sarah L. Gaffen³ and Marc C. Levesque⁶, ¹Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, ²Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) patients are susceptible to infections, even after controlling for the effects of medications. Recent data suggest an important role for the…
Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting
Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages
Yi-Ping Liu¹, Ashley Bomkamp², Jens Eickhoff³, Jack Schneck², Mike Khan⁴ and Judith Smith⁵, ¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, ²University of Wisconsin-Madison, Madison, WI, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, ⁴Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, WI, ⁵Pediatrics, University of Wisconsin-Madison, Madison, WI
Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…

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