Abstracts tagged "IL-23"

Abstract Number: 2838 • 2015 ACR/ARHP Annual Meeting
Evidence of Serological IL-23/IL-17 Axis Activation in Ankylosing Spondylitis Patients with Long-Term TNF Blockade: The Missing Therapy Target?
Fernanda M. Milanez¹, Carla G.S. Saad¹, Vilma S. T. Viana¹, Julio C. B. Moraes¹, Grégory V. Périco², Celio R. Gonçalves¹ and Eloisa Bonfá¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Unidade Radiologica Criciuma, Criciuma, Brazil
Background/Purpose: Spondyloarthritis (Spa) is a group of inflammatory diseases in which ankylosing spondylitis (AS) is the prototype. Despite recent advances in pathophysiology and treatment, this…
Abstract Number: 3056 • 2015 ACR/ARHP Annual Meeting
Increased Circulating Th17 Cells, Serum IL-17 and Serum IL-23 in Takayasu’s Arteritis
Ramnath Misra, Durga Prasanna Misra and Smriti Chaurasia, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: The immune mechanisms underlying Takayasu’s arteritis (TA) are not clear. Expanded Th17 T cell subset has been demonstrated in Giant Cell Arteritis. Gamma delta…
Abstract Number: 199 • 2015 ACR/ARHP Annual Meeting
Human Type 1 and Ncr-Negative Type 3 Innate Lymphoid Cells Accumulate in the Inflamed Synovium in Spondyloarthritis
Nataliya Yeremenko^1,2,3, Silvia Menegatti⁴, Troy Noordenbos^1,2,3, Leonieke J.J. van Mens^1,2, Iris C. Blijdorp^1,2,3, Kristine Germar^1,2,3, Jochem Bernink⁵, Lars Rogge⁴, Hergen Spits⁵ and Dominique Baeten^1,2,3, ¹Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, ²Department of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ³Laboratory of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Immunoregulation Unit, Institut Pasteur, Paris, France, ⁵Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Spondyloarthritis (SpA) is a major form of chronic inflammatory arthritis characterized by inflammation of axial and peripheral joints and by pathologic new bone formation…
Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting
Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis
Nataliya Yeremenko¹, Raquel Celis², Leonie M. van Duivenvoorde³, Julio Ramirez⁴, Iris C. Blijdorp⁵, Sara Marsal⁶, Jose L. Pablos⁷, Raimon Sanmarti⁴, Juan D. Cañete⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁵Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁷Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…
Abstract Number: 806 • 2014 ACR/ARHP Annual Meeting
Association of a Single Nucleotide Polymorphism (SNP) in IL-12B Region with Clinical Features and Peripheral T Cell Profiles of Patients with Takayasu Arteritis
Toshiki Nakajima¹, Hajime Yoshifuji¹, Chikashi Terao², Koji Kitagori¹, Ran Nakashima¹, Yoshitaka Imura³, Naoichiro Yukawa¹, Koichiro Ohmura¹, Takao Fujii¹ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose We preliminarily found a SNP (A vs. C, rs6871626)　in IL-12B region　as a susceptibility gene to Takayasu arteritis (TAK) by genome-wide association study. IL-12Bencodes IL-12/IL-23…
Abstract Number: 632 • 2014 ACR/ARHP Annual Meeting
IL-23 Mediates Psoriasis-like Inflammation in the SKG Mouse Model of Spondyloarthropathy
Helen Benham¹, Linda Rehaume¹, Athan Baillet¹, Zaied Bhuyan¹, Jaclyn Bowman¹, Dimeng Pang¹, Kristine Kikly², Geoffrey Strutton³, Matthew Brown¹ and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co, Indianapolis, IN, ³Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia
Background/Purpose Psoriasis (Ps) is a common immune-mediated inflammatory skin disease and is a well- recognised extra-articular manifestation of the spondyloathopathies (SpA). Genetic studies implicate IL-23…
Abstract Number: 2409 • 2013 ACR/ARHP Annual Meeting
Association Of High Serum Interleukin-23 Levels With Porphyromonas Gingivalis Antibodies In Patients With Early Rheumatoid Arthritis
Sheila L. Arvikar¹, Klemen Strle², Deborah S. Collier³, Mark C. Fisher¹, Toshihisa Kawai⁴, Jose U. Scher⁵ and Allen C. Steere⁶, ¹Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Boston, MA, ⁴Forsyth Institute, Cambridge, MA, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁶Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased frequency of periodontal disease (PD) and antibodies to P. gingivalis (Pg), a major periodontal pathogen. Both…
Abstract Number: 1650 • 2013 ACR/ARHP Annual Meeting
The Route Of T Cell Priming Determines The Requirement For IL-23 In The Development Of Arthritis
Alison Finnegan¹, Yanxia Cao¹ and Susan Olalekan², ¹Dept of Medicine, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Rheumatoid arthritis is a very heterogeneous disease and distinct molecular mechanisms may underlie the disease process. IL-23 is an important cytokine for the expansion…
Abstract Number: 717 • 2013 ACR/ARHP Annual Meeting
Patients With Rheumatoid Arthritis Have Impaired Candida Albicans Specific Th17 Responses But Preserved Oral Candida Albicans Protective Immunity
Shrinivas Bishu¹, E. Wern Su², Erich Wikerson³, Donald M. Jones⁴, Kelly A. Reckley⁵, Sarah L. Gaffen³ and Marc C. Levesque⁶, ¹Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, ²Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) patients are susceptible to infections, even after controlling for the effects of medications. Recent data suggest an important role for the…
Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting
Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages
Yi-Ping Liu¹, Ashley Bomkamp², Jens Eickhoff³, Jack Schneck², Mike Khan⁴ and Judith Smith⁵, ¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, ²University of Wisconsin-Madison, Madison, WI, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, ⁴Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, WI, ⁵Pediatrics, University of Wisconsin-Madison, Madison, WI
Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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