Abstracts tagged "IL-2"

Abstract Number: 86 • 2019 ACR/ARP Annual Meeting
THOR-809: An IL-2 Engineered from an Expanded Genetic Alphabet for the Potential Treatment of Autoimmune Disorders
Jerod Ptacin¹, Carolina Caffaro ¹, Lina Ma ¹, Ingrid Joseph ¹, David Chen ¹, Taylor Ismaili ¹, Kristine San Jose ¹, Yelena Pavlova ¹, Namit Singh ¹, Lilia Koriazova ¹, Hans Aerni ¹, Michael Pena ¹, Jill Mooney ¹ and Marcos Milla ¹, ¹Synthorx, La Jolla, CA
Background/Purpose: CD4+ regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis. Treg dysfunction is associated with multi-organ autoimmune (AI) and inflammatory-related diseases.…
Abstract Number: 1293 • 2019 ACR/ARP Annual Meeting
Multiple Subpopulations of Lymphocytes Were Absolutely Decreased in Dermatomyositis/polymyositis Patients and Restored by Low-dose IL-2
Jia Wang ¹, He-hua Sun ¹, Sheng-xiao Zhang², Jia-qian Zhang ¹, Jiang Bai ³, Jing Luo ³, Cai-hong Wang ⁴, Chong Gao ⁵ and Xiao-feng Li ¹, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), ²The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), ³Shanxi Medical University, Taiyuan, China (People's Republic), ⁴The Second Hospital of Shanxi Medical University, Tai Yuan, China (People's Republic), ⁵Brigham and Women’s Hospital, Harvard Medical School, Boston
Background/Purpose: Dermatomyositis (DM) and polymyositis (PM) are rare chronicinflammatory disorders with significant associated morbidityand mortality despite treatment, characterized by subacute onset of proximal muscle weakness,…
Abstract Number: 2879 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Low-dose IL-2 in Rebuilting Immunity Re-equilibrium of Psoriatic Arthritis Patients
Jia Wang ¹, Yu-fei Hao ², Sheng-xiao Zhang², Quan-run Li ³, Jing-yuan Yang ³, Jia-qian Zhang ¹, Guang-ying Liu ¹, Chong Gao ⁴ and Xiao-feng Li ¹, ¹The Second Hospital of Shanxi Medical University, Taiyuan, China (People's Republic), ²The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China (People's Republic), ³Shanxi Medical University, Taiyuan, China (People's Republic), ⁴Brigham and Women’s Hospital, Harvard Medical School, Boston
Background/Purpose: Psoriatic arthritis (PsA) is a T lymphocytes-mediated inflammatory condition. Although regulatory T cells (Tregs) isolated from blood and psoriatic skin have been showed a…

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