Abstracts tagged "IL-1"

Abstract Number: 1164 • 2015 ACR/ARHP Annual Meeting
Four Types of Calcium Pyrophosphate Crystals Differentially Induce IL-1beta Production By Monocytes through ATP/Potassium Efflux/ROS Dependent Pathways
Laure Campillo-Gimenez¹, Pierre Gras², Félix Renaudin³, Marion Renaud³, Lorène Télot⁴, Amine Mellouk⁵, Pierre Bobé⁵, Jean-Michel Camadro⁴, Christèle Combes², Martine Cohen-Solal^3,6, Frederic Liote^3,6 and Hang-Korng Ea^3,6, ¹Hôpital Lariboisière, Centre Viggo Petersen, INSERM UMR1132, Paris Diderot University, Paris, France, ²ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ³INSERM UMR1132, Paris Diderot University, Paris, France, ⁴CNRS UMR7592, Jacques Monod Institute, Paris Diderot University, Paris, France, ⁵INSERM UMRS757, Paris Sud University, Orsay, France, ⁶AP-HP, Lariboisière Hospital, Rheumatology Department, Paris, France
Background/Purpose: Monoclinic and triclinic calcium pyrophosphate (m- and t-CPP) crystals are the 2 types of CPP crystals observed in human joints. Frequently asymptomatic, it can…
Abstract Number: 1246 • 2015 ACR/ARHP Annual Meeting
Gene Expression Analysis of Adult Onset Still’s Disease and Systemic Juvenile Idiopathic Arthritis Suggest a Single Disease Continuum
N. Nirmala¹, Arndt Brachat², Eugen Feist³, Norbert Blank⁴, Christof Specker⁵, Matthias Witt⁶, Jan Zernicke⁷, Alberto Martini⁸ and Guido Junge⁹, ¹Novartis Institutes for Biomedical Research, Cambridge, MI, ²Novartis Institutes for Biomedical Research, Basel, Switzerland, ³Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany, ⁴University of Heidelberg, Heidelberg, Germany, ⁵Kliniken Essen Süd, Essen, Germany, ⁶Division for Rheumatology, University of Munich, Munich, Germany, ⁷Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁸Department of Pediatrics, G Gaslini Institute, Genova, Italy, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder.1 The superimposable systemic clinical features of AOSD and the pediatric syndrome known as systemic juvenile…
Abstract Number: 931 • 2014 ACR/ARHP Annual Meeting
Response to Canakinumab Treatment Is Maintained in Systemic Juvenile Idiopathic Arthritis Patients
N.M. Wulffraat^1,2, N. Ruperto², H.I. Brunner³, S. Oliveira², Y. Uziel², K. Nistala², R. Cimaz², M. Ferrandiz², B. Flato², M.L. Gamir², I. Koné-Paut², C. Gaillez⁴, K. Lheritier⁴, K. Abrams⁵, A. Martini² and D.J. Lovell³, ¹Pediatric Rheumatology, UMC Utrecht, Utrecht, Netherlands, ²PRINTO-Istituto Gaslini, Genova, Italy, ³PRCSG, Cincinnati, OH, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Canakinumab, a selective, human, anti-interleukin (IL) -1β monoclonal antibody, is approved for the treatment of systemic juvenile idiopathic arthritis (SJIA) patients (≥ 2 years…
Abstract Number: 620 • 2014 ACR/ARHP Annual Meeting
Innate Immune Stimulation Triggers Altered IL-1a/b Gene Expression and Experimental Spondyloarthritis in HLA-B27/huβ2m Transgenic Rats
Melissa N. van Tok^1,2, Leonie M. van Duivenvoorde³, Nimman Satumtira⁴, Martha L. Dorris⁴, Joel D. Taurog⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Spondyloarthritis (SpA) does not display typical features of autoimmune diseases such as female predominance, presence of autoantibodies, or clinical response to T- and/or B…
Abstract Number: 326 • 2014 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonis (IL-1Ra)-Fc Ameliorate Autoimmune Arthritis By Regulation of the Th17 Cells/Treg Balance and Arthrogenic Cytokine Activation
Hong Ki Min¹, Sung Hwan Park², Mi-La Cho³, Ji Hyeon Ju¹, Seung-Ki Kwok⁴, Seon-Yeong Lee³, Seung Min Jung¹, Kyung-Su Park⁵ and Jennifer Lee¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, St. Mary’s hospital, The Catholic University of Korea, Seoul, South Korea, ⁵Internal Medicine, St. Vincent Hospital, SuWon Gyeonggi-do, South Korea
Background/Purpose: : IL-1ß signalling has critical role on pathogenesis of various inflammatory arthritis including rheumatoid arthritis (RA). We aimed to investigate the therapeutic effects of…
Abstract Number: 2283 • 2014 ACR/ARHP Annual Meeting
Steroid-Sparing Effect of Anakinra (Kineret^®) in the Treatment of Patients with Severe Cryopyrin-Associated Periodic Syndrome
Bengt Hallén, Mika Leinonen, Torbjörn Kullenberg and Hans Olivecrona, Swedish Orphan Biovitrum, Stockholm, Sweden
Background/Purpose Cryopyrin-Associated Periodic Syndromes (CAPS) include a group of rare inherited autoinflammatory diseases consisting of FCAS, Muckle-Wells Syndrome and the most severe form, NOMID. Reduction…
Abstract Number: 2176 • 2014 ACR/ARHP Annual Meeting
Macrophages-Mediated Response to Uric Acid Crystals Is Modulated By Their Functional Polarization
Emma Garcia-Melchor¹, Monica Guma², Jordi Yagüe¹, Manel Juan¹ and Jacquie Harper³, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Arthritis and Inflammation Group, Malaghan Institute of Medical Research, Wellington, New Zealand
Background/Purpose: Macrophages have been involved in both initiation and resolution of gout flares. Accordingly, these cells are characterized by their plasticity as the environment modulates…
Abstract Number: 2179 • 2014 ACR/ARHP Annual Meeting
The Monocyte-Phagocyte System in Gout: Enhanced Inflammasome Activity and Expansion of CD14++CD16+ Monocytes in Patients with Gout
Emma Garcia-Melchor¹, Cesar Diaz-Torne², Monica Guma^3,4, Europa Azucena Gonzalez-Navarro⁵, Francesc Xavier Alemany⁶, Jordi Yagüe¹ and Manel Juan¹, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ³Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁴Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Immunology, Hospital Clinic Barcelona, Barcelona, Spain, ⁶Emergency, Hospital Clinic Barcelona, Barcelona, Spain
Background/Purpose: The central role of the monocyte-macrophage system in gout has been highlighted during the last years. Macrophages initiate the inflammatory response to monosodium urate…
Abstract Number: 1817 • 2014 ACR/ARHP Annual Meeting
Connecting Two Pathways through Ca²⁺ Signaling: NLRP3 Inflammasome Activation Induced By a Hypermorphic PLCG2 Mutation
Jae Jin Chae¹, Yong Hwan Park¹, Chung Park², Il-Young Hwang², Patrycja Hoffmann³, John Kehrl², Ivona Aksentijevich³ and Daniel L. Kastner⁴, ¹Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, ²National Institute of Allergy and Infectious Diseases, Bethesda, MD, ³Inflammatory Diseases Section, National Human Genome Research Institute, Bethesda, MD, ⁴Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD
Background/Purpose Previously, we reported that a novel variant, p.Ser707Tyr, in phospholipase Cγ2 (PLCγ2) is the cause of a dominantly inherited autoinflammatory disease, APLAID (autoinflammation and…
Abstract Number: 1222 • 2014 ACR/ARHP Annual Meeting
Suppressive Effect of Butyrate on Monosodium Urate (MSU) Crystal-Induced IL-1beta Production Is Mediated Via Inhibition of Class I Histone Deacetylases
Maartje Cleophas¹, Tania Crisan², Heidi Lemmers³, Helga Toenhake-Dijkstra², Gianluca Fossati⁴, Tim Jansen⁵, Charles Dinarello⁶, Mihai Netea² and Leo Joosten², ¹Internal Medicine, Radboud Unversity Medical Center, Nijmegen, Netherlands, ²Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ³Internal Medicine, Radboud Univeristy Medical Center, Nijmegen, Netherlands, ⁴Department of Preclinical Research and Development, Italfarmaco, Cinisello Balsamo, Italy, ⁵Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO
Background/Purpose Gouty arthritis is triggered by endogenously formed monosodium urate (MSU) crystals. MSU crystals alone are unable to induce cytokine production and therefore a second…
Abstract Number: 1232 • 2014 ACR/ARHP Annual Meeting
Canakinumab Therapy in Patients with Familial Mediterranean Fever
Serdal Ugurlu, Emire Seyahi, Gulen Hatemi, Aysa Hacioglu, Fatma Nihan Akkoc and Huri Ozdogan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: According to a recent pilot study Canakinumab reduced the frequency of attacks in 9 patients with Familial Mediterranean Fever (FMF) resistant to colchicine with no…
Abstract Number: 1194 • 2014 ACR/ARHP Annual Meeting
Cofilin-1 Is a ROS Sensor in Regulating the NLRP3 Inflammasome
Yong Hwan Park¹, Daniel L. Kastner² and Jae Jin Chae¹, ¹Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD
Background/Purpose NLRP3 (NOD-like receptor family, pyrin domain containing 3) has a pivotal role in nucleating inflammasome, cytoplasmic multiprotein complexes that mediate the maturation of the…
Abstract Number: 1042 • 2014 ACR/ARHP Annual Meeting
IL-1β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression By Rheumatoid Arthritis Synovial Fibroblasts
Christelle Darrieutort-Laffite^1,2, Marie Astrid Boutet¹, Mathias Chatelais¹, Regis Brion³, Frederic Blanchard¹, Dominique Heymann³ and Benoit Le Goff^1,2, ¹Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, INSERM, UMR 957, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, INSERM, UMR 957, Nantes, France
Background/Purpose Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). They can interact in the synovial micro-environment…
Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
W. Alexander Stinson¹, Phillip L. Campbell¹, Jeffrey Ruth², Gautam Edhayan², Ray A. Ohara², Nicholas Lepore³, Alisa E. Koch⁴, David A. Fox² and M. Asif Amin², ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
Abstract Number: 1780 • 2013 ACR/ARHP Annual Meeting
The Randomized Placebo Phase Study of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis
Norman T. Ilowite¹, Kristi Prather², Yuliya Lokhnygina³, Laura E. Schanberg⁴, Melissa Elder⁵, Diana Milojevic⁶, James W. Verbsky⁷, Steven J. Spalding⁸, Yukiko Kimura⁹, Lisa F. Imundo¹⁰, Marilynn G. Punaro¹¹, David D. Sherry¹², Stacey E. Tarvin¹³, Lawrence S. Zemel¹⁴, James D. Birmingham¹⁵, Beth S. Gottlieb¹⁶, Michael L. Miller¹⁷, Kathleen M. O'Neil¹⁸, Natasha M. Ruth¹⁹, Carol A. Wallace²⁰, Nora G. Singer²¹ and Christy I. Sandborg²², ¹Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ²Statistics, Duke Clinical Research Institute, Durham, NC, ³Duke Clinical Research Institute, Durham, NC, ⁴Pediatrics, Duke University Medical Center, Durham, NC, ⁵Pediatrics, University of Florida, Gainesville, HI, ⁶Dept of Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, ⁸Pediatric Institute, Department of Pediatric Rheumatology, The Cleveland Clinic, Cleveland, OH, ⁹Pediatric Rheumatology, Joseph M Sanzari Children’s Hospital, Hackensack University Medical Center, Hackensack, NJ, ¹⁰Pediatric and Adult Rheumatology Columbia University Medical Center, New York, NY, ¹¹Pediatric Rheumatology, Texas Scottish Rite Hospital, Dallas, TX, ¹²Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ¹³Pediatric Rheumatology, Riley Hospital for Children, Indianapolis, IN, ¹⁴Pediatric Rheumatology Collaborative Study Group, Cincinnati, OH, ¹⁵Medicine & Pediatrics, Rheumatology, Michigan State University College of Human Medicine, Grand Rapids, MI, ¹⁶Pediatric Rheumatology, Cohen Children's Medical Center of New York, New Hyde Park, NY, ¹⁷Rheumatology, Childrens Memorial Hospital, Chicago, IL, ¹⁸Division of Pediatric Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁹Pediatric Rheumatology, Medical University of South Carolina, Charleston, SC, ²⁰University of Washington School of Medicine and Seattle Children's Hospital, Seattle, WA, ²¹Rheumatology, MetroHealth Medical Center, Cleveland, OH, ²²Pediatric Rheumatology, Stanford University, Palo Alto, CA
Background/Purpose: The RAndomized Placebo Phase Study Of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis (RAPPORT) is a multicenter controlled trial using a…

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