Abstracts tagged "IL-1"

Abstract Number: 2128 • 2016 ACR/ARHP Annual Meeting
Autophagic Clearance of Dysfunctional Mitochondria Requires Parkin in Human Chondrocytes
Mohammad Y Ansari¹ and Tariq M. Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose:
Abstract Number: 939 • 2015 ACR/ARHP Annual Meeting
Long-Term Efficacy and Safety of Canakinumab in Active Hyperimmunoglobulinemia D with Periodic Fever Syndrome
Juan Ignacio Arostegui¹, Jordi Anton², Inmaculada Calvo-Penedes³, Angel Robles⁴, Antonio Speziale⁵, Yolandi Joubert⁵, Guido Junge⁵ and Jordi Yagüe⁶, ¹Department of Immunology-CDB, Hospital Clínic, Barcelona, Spain, ²Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ³Hospital de La Fe, Valencia, Spain, ⁴Hospital La Paz, Madrid, Spain, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain
Background/Purpose: Hyperimmunoglobulinemia D with periodic fever syndrome (HIDS) is a recessively inherited disorder characterized by periodic episodes of high fever, abdominal distress, joint pain, and…
Abstract Number: 1136 • 2015 ACR/ARHP Annual Meeting
IL-1β-Induced Stress Granules Sequester COX-2 mRNA and Regulates Its Expression in Human OA Chondrocytes
Mohammad Ansari¹ and Tariq Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Stress granules (SGs) are ribonucleoprotein complexes assembled in the cytoplasm of eukaryotic cells to respond adequately to stress (e.g. heat shock, UV irradiation, oxidative…
Abstract Number: 1164 • 2015 ACR/ARHP Annual Meeting
Four Types of Calcium Pyrophosphate Crystals Differentially Induce IL-1beta Production By Monocytes through ATP/Potassium Efflux/ROS Dependent Pathways
Laure Campillo-Gimenez¹, Pierre Gras², Félix Renaudin³, Marion Renaud³, Lorène Télot⁴, Amine Mellouk⁵, Pierre Bobé⁵, Jean-Michel Camadro⁴, Christèle Combes², Martine Cohen-Solal^3,6, Frederic Liote^3,6 and Hang-Korng Ea^3,6, ¹Hôpital Lariboisière, Centre Viggo Petersen, INSERM UMR1132, Paris Diderot University, Paris, France, ²ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ³INSERM UMR1132, Paris Diderot University, Paris, France, ⁴CNRS UMR7592, Jacques Monod Institute, Paris Diderot University, Paris, France, ⁵INSERM UMRS757, Paris Sud University, Orsay, France, ⁶AP-HP, Lariboisière Hospital, Rheumatology Department, Paris, France
Background/Purpose: Monoclinic and triclinic calcium pyrophosphate (m- and t-CPP) crystals are the 2 types of CPP crystals observed in human joints. Frequently asymptomatic, it can…
Abstract Number: 1246 • 2015 ACR/ARHP Annual Meeting
Gene Expression Analysis of Adult Onset Still’s Disease and Systemic Juvenile Idiopathic Arthritis Suggest a Single Disease Continuum
N. Nirmala¹, Arndt Brachat², Eugen Feist³, Norbert Blank⁴, Christof Specker⁵, Matthias Witt⁶, Jan Zernicke⁷, Alberto Martini⁸ and Guido Junge⁹, ¹Novartis Institutes for Biomedical Research, Cambridge, MI, ²Novartis Institutes for Biomedical Research, Basel, Switzerland, ³Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany, ⁴University of Heidelberg, Heidelberg, Germany, ⁵Kliniken Essen Süd, Essen, Germany, ⁶Division for Rheumatology, University of Munich, Munich, Germany, ⁷Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ⁸Department of Pediatrics, G Gaslini Institute, Genova, Italy, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder.1 The superimposable systemic clinical features of AOSD and the pediatric syndrome known as systemic juvenile…
Abstract Number: 1364 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with the Innate Immune Inhibitor IL-37 Reduces Joint and Systemic Inflammation
Giulio Cavalli¹, Marije Koenders², Lorenzo Dagna³, Alberto Mantovani⁴, Cecilia Garlanda⁴, Leo Joosten⁵ and Charles Dinarello¹, ¹Department of Medicine, Division of Infectious Diseases, University of Colorado, Denver, CO, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milano, Italy, ⁴Research Institute Humanitas, Milan, Italy, ⁵Internal Medicine, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Characterized as a fundamental inhibitor of innate inflammation, IL‑1 family member IL‑37 is expressed in the synovia of patients with rheumatoid arthritis. We investigated…
Abstract Number: 2346 • 2015 ACR/ARHP Annual Meeting
Rebamipide Suppresses Monosodium Urate Crystal-Induced Interleukin-1b Production through Regulation of Oxidative Stress and Caspase-1 in THP-1 Cells
Jung-Yoon Choe¹, Minyoung Her² and Seong-Kyu Kim³, ¹Division of Rheumatology, Daegu Catholic University Medical Center, Daegu, South Korea, ²Busan Paik Hospital, Inje University, Busan, South Korea, ³Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, South Korea
Background/Purpose: This study investigated the effect of rebamipide on activation of NLRP3 inflammasome and reactive oxygen species (ROS) in monosodium urate (MSU) crystal-induced interleukin-1b (IL-1b)…
Abstract Number: 3224 • 2015 ACR/ARHP Annual Meeting
Salivary IL-1 Alpha and IL-1 Beta Levels Are Associated with Oral Mucosal Activity in Behcet’s Disease
Nilufer Alpay Kanitez¹, Bahtiyar Toz¹, Feyza Berktas¹, Sertan Ergun², Meltem Koray², Nuray Gurel Polat³, Burak Erer¹ and Ahmet Gül¹, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Department of Oral Medicine, Istanbul University, Faculty of Dentistry, Istanbul, Turkey, ³Department of Microbiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Recurrent oral aphthous ulcers are the common manifestation of the Behçet's disease (BD), and they are indistinguishable from ulcers of recurrent aphthous stomatitis (RAS).…
Abstract Number: 14 • 2015 ACR/ARHP Annual Meeting
The SLE Susceptibility Gene Macrophage Migration Inhibitory Factor Serves As an Upstream Regulator of NLRP3 (NOD-like receptor family pyrin domain containing 3) Expression and Subsequent IL-1beta Production in Human Monocytes in Response to Lupus U1-snRNP Immune Complex
Min Sun Shin¹, Youna Kang¹, Elizabeth Wahl¹, Lin Leng¹, Richard Bucala¹ and Insoo Kang², ¹Yale University School of Medicine, New Haven, CT, ²Rheumatology Section, Yale University School of Medicine, New Haven, CT
Background/Purpose: The pathologic hallmarks of systemic lupus erythematosus (SLE or lupus) are altered immune responses to nuclear autoantigens with autoantibody production and subsequent tissue injury.…
Abstract Number: 18 • 2015 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts
Anil Singh^1,2, Mukesh Chourasia³ and Salahuddin Ahmed⁴, ¹Department of Pharmaceutical Science, Washington State University, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ³Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, ⁴Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: TAK1 is one of the most important proteins in IL-1β signaling cascade that mediates downstream p38/JNK and NF-κB activation. In the present study, we…
Abstract Number: 19 • 2015 ACR/ARHP Annual Meeting
Pentagalloyl Glucose (PGG) Exhibits Anti-Rheumatic Activity in Human RA Synovial Fibroblasts and Rat Adjuvant-Induced Arthritis
Sadiq Umar¹, Gates Roe¹, Sabrina Fechtner¹ and Salahuddin Ahmed², ¹Department of Pharmaceutical Science, Washington State University College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: Pentagalloyl glucose (PGG) is a natural polyphenolic and water-soluble gallotannin that exhibits anti-cancer and anti-inflammatory activities. In the present study, we evaluated the efficacy…
Abstract Number: 195 • 2015 ACR/ARHP Annual Meeting
Activation of the Pyrin Inflammasome through the RhoA Signaling Pathway in Familial Mediterranean Fever (FMF) and Hyperimmunoglobulinemia D Syndrome (HIDS)
Yong Hwan Park, Geryl Wood, Daniel Kastner and Jae Jin Chae, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, NIH/NHGRI, Bethesda, MD
Background/Purpose: Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause the autoinflammatory diseases familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS), respectively. …
Abstract Number: 254 • 2015 ACR/ARHP Annual Meeting
The Interleukin-1 Inhibitor Canakinumab for Familial Mediterranean Fever: Long-Term Beneficial Effect in a Cohort of 13 Patients
KATERINA LASKARI¹, PANAGIOTA BOURA², GEORGE N DALEKOS³, ALEXANDROS GARYFALLOS⁴, DIMITRIOS KAROKIS⁵, DIMITRIOS PIKAZIS⁶, LOUKAS SETTAS⁷, GRIGORIS SKARANTAVOS⁸, ELENA TSITSAMI⁹ and PETROS P SFIKAKIS¹⁰, ¹Rheumatology Unit, 1st Dept. of Propaedeutic Internal Medicine, Athens University Medical School, Athens, Greece, ²Clinical Immunology Unit, 2nd Dept. of Internal Medicine, Aristotle University Medical School, Thessaloniki, Greece, ³Thessaly University Medical School, Larissa, Greece, ⁴4th Department of Internal Medicine, Aristotle University Medical School, Thessaloniki, Greece, ⁵Private rheumatologist, Patras, Greece, ⁶Pathophysiology, Athens University Medical School, Athens, Greece, ⁷First Dept. of Internal Medicine, Rheumatology Section, Aristotle University Medical School, Thessaloniki, Greece, ⁸Bone Metabolic Unit, 1st Dept. of Orthopedics, Athens University Medical School, Athens, Greece, ⁹First Department of Pediatrics, Athens University Medical School, Athens, Greece, ¹⁰1st Dept. of Propaedeutic Internal Medicine, Athens University Medical School, Athens, Greece
Background/Purpose: Interleukin-1 (IL-1) is a major mediator of the inflammatory cascade in Familial Mediterranean Fever (FMF) and an established therapeutic target (1). To retrospectively assess…
Abstract Number: 318 • 2015 ACR/ARHP Annual Meeting
Dual Variable Domain-Immunoglobulin (Dvd-Igâ„¢) Abt-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Î‘lpha and -1 Î’eta in Subjects with Knee Osteoarthritis
Susanne X. Wang¹, Ralf Loebbert², Erik Sampson³, Mary Saltarelli¹, Jeroen Medema¹ and Feng Hong³, ¹AbbVie Inc., North Chicago, IL, ²AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ³AbbVie Inc., Worcester, MA
Background/Purpose: ABT-981 is a novel human Dual-Variable Domain Immunoglobulin (DVD-Ig™) that inhibits interleukin (IL)-1α and IL-1β. The purpose of this study is to evaluate IL-1α…
Abstract Number: 319 • 2015 ACR/ARHP Annual Meeting
Phase 1 Studies of Anti-Interleukin-1 Dual-Variable Domain Immunoglobulin in Healthy Subjects and Patients with Osteoarthritis
Susanne X. Wang¹, Wei Liu¹, Ping Jiang¹, Martin Okun¹, Richard Preston², Carlos J. Lozada², David Carter¹ and Jeroen Medema¹, ¹AbbVie Inc., North Chicago, IL, ²University of Miami Miller School of Medicine, Miami, FL
Background/Purpose: Interleukin (IL)-1 is a catabolic cytokine that plays an important role in pathogenesis and progression of osteoarthritis (OA). Two phase 1 clinical trials investigated…

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