Abstracts tagged "IL-1 and T-Regulatory Cells"

Abstract Number: 2712 • 2017 ACR/ARHP Annual Meeting
Autoimmune Arthritis in IL-1 Receptor Antagonist-Deficient Mice Is Associated with a Pathogenic Conversion of Foxp3+ Regulatory T Cells into Th17 Cells
Anais Levescot¹, Nathan Nelson-Maney², Allyn Morris³, Ricardo Grieshaber Bouyer⁴, Pui Lee⁵ and Peter Nigrovic⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, BWH, Boston, MA, ⁵Harvard Medical School, Boston, MA, ⁶Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: IL-1β blockade is a highly effective therapy for systemic juvenile idiopathic arthritis (sJIA). However, the rate of inactive disease attained in these trials is…

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