Abstracts tagged "IL-1 and stress"

Abstract Number: 70 • ACR/ARHP Annual Meeting 2017
Excessive Cyclic Compressive Stress Increases Susceptibility to IL-1 in 3D-Cultured Chondrocytes
Yuki Takeda¹, Yasuo Niki², Yusuke Fukuhara², Yoshitsugu Fukuda², Kazuhiko Udagawa², Toshiyuki Kikuchi², Takeshi Miyamoto², Morio Matsumoto² and Masaya Nakamura², ¹Department of Orthopaedic Surgery, Keio University, Tokyo, Japan, ²Keio University, Tokyo, Japan
Background/Purpose: The mechanism of chondrocyte mechanotransduction is not fully understood. Recently, transient receptor potential vanilloid 4 (TRPV4) has been reported to transduce dynamic compressive loading…