Abstracts tagged "IL-1 and major histocompatibility complex (MHC)"

Abstract Number: 2034 • ACR/ARHP Annual Meeting 2016
Novel Susceptible Genes for Behçet’s Disease Identified By Dense Genotyping of Immune-Related Loci Implicate Host Responses to Microbial Exposure
Masaki Takeuchi^1,2, Nobuhisa Mizuki³, Akira Meguro⁴, Michael J. Ombrello⁵, Yohei Kirino⁶, Colleen Satorius⁷, Julie Le¹, Mary Blake⁸, Burak Erer⁹, Tatsukata Kawagoe², Duran Ustek¹⁰, Ilknur Tugal-tutkun¹¹, Emire Seyahi¹², Yilmaz Ozyazgan¹³, Inês Sousa¹⁴, Fereydoun Davatchi¹⁵, Vânia Francisco¹⁴, Farhad Shahram¹⁶, Bahar Abdollahi¹⁷, Abdolhadi Nadji¹⁷, Niloofar Shafiee¹⁷, Fahmida Ghaderibarmi¹⁸, Shigeaki Ohno¹⁹, Atsuhisa Ueda⁶, Yoshiaki Ishigatsubo²⁰, Massimo G. Gadina²¹, Sofia Oliveira¹⁴, Ahmet Gul⁹, Daniel L. Kastner¹ and Elaine F. Remmers²², ¹National Human Genome Research Institute, Bethesda, MD, ²Yokohama City University Graduate School of Medicine, Yokohama, Japan, ³Yokohama City University, Yokohama, Japan, ⁴Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁵Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD, ⁶Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁷NIAMS, N.I.H, Bethesda, MD, ⁸National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ¹⁰Istanbul University, Istanbul, Turkey, ¹¹Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ¹²Istanbul University, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ¹³Ophthalmology, Istanbul University, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, ¹⁴Universidade de Lisboa, Lisboa, Portugal, ¹⁵Internal Medicine, Rheumatology Research Ctr-Tehran Univ, Tehran, Iran, ¹⁶Tehran University of Medical Sciences, Tehran, Iran (Islamic Republic of), ¹⁷Tehran University of Medical Sciences, Teheran, Iran (Islamic Republic of), ¹⁸Tehran University of Medical Sciences, Teheran, Portugal, ¹⁹Hokkaido University Graduate School of Medicine, Hokkaido, Japan, ²⁰Int. Med. & Clin. Immunology, Yokohama City Grad Sch of Med, Yokohama, Japan, ²¹Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Recent genetic studies have identified multiple susceptibility loci for Behçet’s disease. However, these genetic factors do not fully explain the apparent disease heritability.The purpose…