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Abstracts tagged "IL-1 and interferons"

  • Abstract Number: 1898 • ACR/ARHP Annual Meeting 2014

    Identification of “autoinflammatory interferonopathies”?   a New Class of Autoinflammatory Conditions?

    Adriana Almeida de Jesus1, Zuoming Deng2, Stephen Brooks3, Yin Liu4, Hanna Kim4, Gina A. Montealegre Sanchez4, Dawn C. Chapelle4, Yan Huang4, Philip Hashkes5, Gulnara Nasrullayeva6, Maria Teresa Terreri7, Bita Arabshahi8, Marilynn G. Punaro9, Lakshmi N. Moorthy10, Adam Reinhardt11, Clovis A. Silva12, Emilia I. Sato13, Vibke Lilleby14, Thomas Fleisher15 and Raphaela Goldbach-Mansky4, 1Translational Autoinflammatory Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 2Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 3NIAMS/NIH, Bethesda, MD, 4Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 5Pediatric Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, 6Head Immunology Department, Azerbaijan Medical University, Baku, Azerbaijan, 7University of Federal De Sao Paulo, Sao Paulo, Brazil, 8Pediatric Rheumatology, Inova Fairfax Hospital for Children, Fairfax, VA, 9Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, 10Pediatric Rheumatology, Robert Wood Johnson Medical School-Rutgers University, New Brunswick, NJ, 11Pediatric Rheumatology, Children's Specialty Physicians, Omaha, NE, 12Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 13Rheumatology Div/Dept of Med, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 14Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, 15Chief Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD

    Background/Purpose The role of IL-1 in the pathogenesis of many of the monogenic autoinflammatory diseases is clinically validated by the response to IL-1 blocking therapies.…

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