Abstracts tagged "IFN"

Abstract Number: 1497 • ACR Convergence 2021
Kidney Disease in Lupus Patients Is Linked to Monocytes’ Aberrant Spliceosome and Altered Expression of IFN-Response Related Genes
Chary Lopez-Pedrera¹, Alejandra Patiño-Trives², Alejandro Ibañez-Costa³, Maria Luque-Tevar², Iván Arias de la Rosa⁴, Desiree Ruiz⁵, Pedro Seguí-Azpilicueta⁵, Mario Espinosa⁵, Rosa Ortega⁵, Nuria Barbarroja⁴, Justo P Cataño³, Raul Luque³, Maria Angeles Aguirre¹ and Carlos Pérez-Sánchez⁶, ¹IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ²Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ³IMIBIC, Department of Cell Biology, Physiology and Immunology, University of Cordoba, Córdoba, Spain, ⁴University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁵IMIBIC, Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ⁶IMIBIC, Córdoba, Spain
Background/Purpose: The present study aimed at: 1- Identifying altered SLE monocytes transcriptomic signatures linked to the immune response and its association with clinical features. 2-…
Abstract Number: 2036 • ACR/ARP Annual Meeting 2019
Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An¹, Bhargavi Duvvuri ¹, Xizhang Sun ¹, Lena Tanaka ¹, Christian Lood ¹ and Keith Elkon ¹, ¹University of Washington, Seattle
Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some…