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Abstracts tagged "ICOS"

  • Abstract Number: 1531 • ACR/ARP Annual Meeting 2019

    ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Underlying Rheumatoid and Psoriatic Arthritis

    Lawrence Evans1, Stacey Dillon 1, Katherine Lewis 1, Susan Bort 1, Erika Rickel 1, Jing Yang 1, Martin Wolfson 1, Sherri Mudri 1, Kayla Susmilch 1, Steven Levin 1, Sean MacNeil 1, Mark Rixon 1, Jan Hillson 2, Stanford Peng 1 and Kristine Swiderek 1, 1Alpine Immune Sciences, Seattle, WA, 2Alpine Immune Sciences, Seattle, WI

    Background/Purpose: ALPN-101 is an Fc fusion protein of a human inducible T cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgDTM) designed to simultaneously inhibit the…
  • Abstract Number: 2416 • ACR/ARP Annual Meeting 2019

    ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Associated with Sjögren’s Syndrome

    Stacey Dillon1, Lawrence Evans 1, Katherine Lewis 1, Susan Bort 1, Erika Rickel 1, Jing Yang 1, Martin Wolfson 1, Kayla Susmilch 1, Sherri Mudri 1, Steven Levin 1, Janhavi Bhandari 1, Fariha Ahmed-Qadri 1, Mark Rixon 1, Jan Hillson 2, Stanford Peng 1 and Kristine Swiderek 1, 1Alpine Immune Sciences, Seattle, WA, 2Alpine Immune Sciences, Seattle, WI

    Background/Purpose: ALPN-101 is an Fc fusion protein of a human inducible T cell costimulator ligand (ICOSL) variant immunoglobulin domain (vIgDTM) designed to inhibit simultaneously the…

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