ACR Meeting Abstracts

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Abstracts tagged "hypoxia"

  • Abstract Number: 0066 • ACR Convergence 2020

    AMP Deaminase 2 Is Expressed on the Surface of Human Immune Cells as a Novel Regulator of Extracellular Adenosine Metabolism

    Lisa Ehlers1, Aditi Kuppe1, Marieluise Kirchner2, Alexandra Damerau1, Cindy Strehl1, Frank Buttgereit3 and Timo Gaber1, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Max Delbrück Center for Molecular Medicine, BIH Core Facility Proteomics, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…
  • Abstract Number: 0116 • ACR Convergence 2020

    The in Vitro 3D Fracture Gap Model: A Tool for Preclinical Testing

    Moritz Pfeiffenberger1, Alexandra Damerau1, Paula Hoff2, Annemarie Lang1, Frank Buttgereit3 and Timo Gaber1, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Endokrinologikum Berlin, Rheumatologie, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: Approximately 10% of fractures lead to significant fracture healing disorders. Of note, especially immunosuppressed patients with ongoing inflammation show difficulties in the correct course…
  • Abstract Number: 0991 • ACR Convergence 2020

    Pathogenic, Glycolytic PD-1+ B Cells Accumulate in the Hypoxic RA Joint

    Achilleas Floudas1, Nuno Neto2, Viviana Marzaioli3, Kieran Murray4, Barry Moran5, Michael Monaghan6, Candice Low7, Ronan Mullan8, Navin Rao9, Vinod Krishna9, Sunil Nagpal10, Douglas Veale11 and Ursula Fearon3, 1Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, 2Department of Mechanical and Manufacturing Engineering, Dublin, Dublin, Ireland, 3Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, 5Trinity Biomedical Sciences Institute, Dublin, Ireland, 6Department of Mechanical and Manufacturing Engineering, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, 8Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 9Janssen R&D, Spring House, PA, 10Janssen Research & Development, Collegeville, PA, 11EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) often has a progressive and debilitating course, with significant impact on the patient’s quality of life. Despite the long-known association with…
  • Abstract Number: 1801 • ACR Convergence 2020

    An Engineered Extracellular Matrix‐rich Decellularized Substrate Based Podocytes Culture System to Study Intracellular Complement Production and Activation

    Abhigyan Satyam1, Maria Tsokos2 and George Tsokos2, 1Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, boston, 2Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: Current technologies do not support long-term cell viability, differentiation and maintenance of podocytes. We developed a biophysical approach, termed macromolecular crowding (MMC), to create…
  • Abstract Number: 2862 • 2019 ACR/ARP Annual Meeting

    Hypoxia Resistant Pathogenic B Cells Accumulate in the RA Synovial Tissue in a CXCR3 Dependent Manner

    Achilleas Floudas1, Candice Low 2, Monika Biniecka 3, Kieran Murray 2, Ronan Mullan 4, Douglas Veale 5 and Ursula Fearon 6, 1Trinity Biomedical Sciences Institu, DUBLIN, Ireland, 2Saint Vincent's University Hospital, Dublin, Ireland, 3Molecular Rheumatology, Trinity Biomedical Sciences Institute, DUBLIN, Ireland, 4Dept of Rheumatology, Tallaght University Hospital, TCD, Dublin, Ireland, 5EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland, 6Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown and complex aetiology with severe detrimental effects for the patient’s quality of life.…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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