Abstracts tagged "human leukocyte antigens (HLA) and statins"

Abstract Number: 2001 • 2015 ACR/ARHP Annual Meeting
Reduction of HLA Class II Expression and Beta-2-Glycoprotein I Presentation By Fluvastatin in Vitro and in Vivo: Possible Mechanism of Statin-Induced-Deprocoagulation in the Antiphospholipid Syndrome
Toshiyuki Watanabe^1,2, Kenji Oku¹, Olga Amengual¹, Ryo Hisada¹, Kazumasa Ohmura¹, Haruki Shida¹, Yuka Shimizu¹, Masaru Kato¹, Toshiyuki Bohgaki¹, Tetsuya Horita¹, Shinsuke Yasuda¹, Akihiro Ishizu³, Hisashi Arase⁴ and Tatsuya Atsumi¹, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²3rd Department of Internal medicine, Hokkaido P.W.F.A.C Obihiro-Kosei General Hospital, Obihiro, Japan, ³Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, ⁴Laboratory of Immunochemistry, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan
Background/Purpose: Human leukocyte antigen (HLA)-DRB1*07:01 is one of the susceptibility alleles for antiphospholipid syndrome (APS). Recently we have reported that beta-2-glycoprotein I (b2GPI) /HLA class…

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