Abstracts tagged "human leukocyte antigens (HLA) and spondylarthropathy"

Abstract Number: 1580 • 2017 ACR/ARHP Annual Meeting
HLA-B27/ Human β2-Microglobulin (β2m) Transgenic Drosophila Expresses Specific Cross-Vein Less (CVL) and Small-Eye Phenotypes Resulting from Disruption of the BMP/TGFβ Signaling Pathway
Benjamin Grandon¹, Nadège Jah², Aurore Rincheval-Arnold³, Isabelle Guénal³, Sébastien Gaumer³, Claudine Andre², Maxime Breban⁴ and Gilles Chiocchia⁵, ¹Inserm UMR 1173 and LGBC, 78180 Saint Quentin en Yvelines, France, ²Infection and inflammation, INSERM UMR1173, Montigny-le-Bretonneux, France, ³Laboratory of Genetic and Cellular Biology, Faculty of Health Sciences Simone Veil, Montigny-le-Bretonneux,, 78180 SAINT QUENTIN EN YVELINES, France, ⁴Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, ⁵Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France
Background/Purpose: The association between HLA-B27 and spondyloarthritis (SpA) remains unexplained more than 40 years after its discovery. To further explore the pathogenic role of HLA-B27,…
Abstract Number: 594 • 2012 ACR/ARHP Annual Meeting
Evidence of Human Leucozyte Antigen-B27 in Healthy Individuals and Patients with Uveitis Is a Risk Factor for Alterations in Bone Metabolism
Sarah Schmidt¹, Stephanie Finzel¹, Jürgen Rech², Matthias Englbrecht¹, Silke Winkler¹, Isabel Schmidt¹, Roula Said-Nahal³, Maxime A. Breban³ and Georg A. Schett¹, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medizinische Klinik 3, University of Erlangen-Nuremberg, Erlangen, Germany, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: To test whether positivity for HLA-B27 per se is associated with changes of biomarkers of the Wnt pathway. HLA-B27 is strongly associated with the…