ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "human leukocyte antigens (HLA) and spondylarthritis"

  • Abstract Number: 1910 • 2017 ACR/ARHP Annual Meeting

    ERAP1 Deficiency Implicates Long Peptides in Protection from HLA-B27-Induced Experimental Spondyloarthritis

    Tri Tran1, Tejpal Gill1, Joshua R. Bennett1, Vance Holt1, Sohee Hong2, Joel Taurog3 and Robert Colbert1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2National Institutes of Arthritis and Muskuloskeletal and skin diseases, National Institutes of Health, Bethesda, MD, 3Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Common endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) haplotypes influence the risk of developing axial spondyloarthritis (SpA) in HLA-B27-positive individuals, with loss-of-function and reduced expression…
  • Abstract Number: 1717 • 2015 ACR/ARHP Annual Meeting

    Factors Associated with the Decision of the Rheumatologist to Order Sacro-Iliac Joints Magnetic Resonance Imaging (SI-MRI) or Order HLA-B27 Testing in Patients with Spondyloarthritis in Clinical Practice

    Wilson Bautista-Molano1,2, Robert Landewé3, Cesar Serna4, Rafael R. Valle5 and Désirée van der Heijde6, 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, 2Department of Rheumatology, Faculty of Medicine HMC/UMNG, Bogota, Colombia, Bogotá, Colombia, 3Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 4Statistics and Mathematics Department, Universidad Central, Bogotá, Colombia, Bogotá, Colombia, 5Rheumatology/Immunology, Department of Rheumatology, Faculty of Medicine HMC/UMNG, Bogota, Colombia, Bogota, Colombia, 6Dept. of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Magnetic resonance imaging of sacroiliac joints (MRI-SI) and HLA-B27 testing are important tools in the diagnosis of spondyloarthritis (SpA). The aim of the study…
  • Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting

    The HLA-B27 Peptidome in Vivo in Transgenic Rats

    Joel D. Taurog1, Yael Haimovich2, Eilon Barnea3, Michal Bassani-Sternberg3, Shira Yair-Sabag2, Martha L. Dorris1, Nimman Satumtira1, Mylinh Nguyen4, Robert E. Hammer4, Tri M. Tran5, Robert A. Colbert5 and Arie Admon3, 1Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, 2Technion-Israel Institute of Technology, Haifa, Israel, 3Biology, Technion-Israel Institute of Technology, Haifa, Israel, 4Biochemistry, UT Southwestern Medical Center, Dallas, TX, 5NIAMS/NIH, Bethesda, MD

    Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…
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