Abstracts tagged "human leukocyte antigens (HLA) and spondylarthritis"

Abstract Number: 1910 • 2017 ACR/ARHP Annual Meeting
ERAP1 Deficiency Implicates Long Peptides in Protection from HLA-B27-Induced Experimental Spondyloarthritis
Tri Tran¹, Tejpal Gill¹, Joshua R. Bennett¹, Vance Holt¹, Sohee Hong², Joel Taurog³ and Robert Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²National Institutes of Arthritis and Muskuloskeletal and skin diseases, National Institutes of Health, Bethesda, MD, ³Dept Int Med-Rheum Dis Div, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Common endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) haplotypes influence the risk of developing axial spondyloarthritis (SpA) in HLA-B27-positive individuals, with loss-of-function and reduced expression…
Abstract Number: 1717 • 2015 ACR/ARHP Annual Meeting
Factors Associated with the Decision of the Rheumatologist to Order Sacro-Iliac Joints Magnetic Resonance Imaging (SI-MRI) or Order HLA-B27 Testing in Patients with Spondyloarthritis in Clinical Practice
Wilson Bautista-Molano^1,2, Robert Landewé³, Cesar Serna⁴, Rafael R. Valle⁵ and Désirée van der Heijde⁶, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ²Department of Rheumatology, Faculty of Medicine HMC/UMNG, Bogota, Colombia, Bogotá, Colombia, ³Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, ⁴Statistics and Mathematics Department, Universidad Central, Bogotá, Colombia, Bogotá, Colombia, ⁵Rheumatology/Immunology, Department of Rheumatology, Faculty of Medicine HMC/UMNG, Bogota, Colombia, Bogota, Colombia, ⁶Dept. of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Magnetic resonance imaging of sacroiliac joints (MRI-SI) and HLA-B27 testing are important tools in the diagnosis of spondyloarthritis (SpA). The aim of the study…
Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting
The HLA-B27 Peptidome in Vivo in Transgenic Rats
Joel D. Taurog¹, Yael Haimovich², Eilon Barnea³, Michal Bassani-Sternberg³, Shira Yair-Sabag², Martha L. Dorris¹, Nimman Satumtira¹, Mylinh Nguyen⁴, Robert E. Hammer⁴, Tri M. Tran⁵, Robert A. Colbert⁵ and Arie Admon³, ¹Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ²Technion-Israel Institute of Technology, Haifa, Israel, ³Biology, Technion-Israel Institute of Technology, Haifa, Israel, ⁴Biochemistry, UT Southwestern Medical Center, Dallas, TX, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…