Abstracts tagged "HLA B27"

Abstract Number: 0048 • ACR Convergence 2021
A Novel Technology to Study the Role of Intestinal Biology in Spondyloarthritis Pathogenesis: Human Colonic Organoids and Epithelial Monolayers
Manuel Rodriguez¹, Alec Furst¹, James T. Rosenbaum² and Tejpal Gill¹, ¹Oregon Health & Science University, Portland, OR, ²Departments of Ophthalmology, Medicine, and Cell Biology, Oregon Health & Sciences University and Chair Emeritus, Legacy Devers Eye Institute, Portland, OR
Background/Purpose: Ankylosing spondylitis (AS) is a complex genetic disease with strong association to the human leukocyte antigen (HLA)-B27. Several observations including frequent, occult histologic evidence…
Abstract Number: 0052 • ACR Convergence 2021
HLA-B27 Is Associated with Altered Mucosal IgA Response to Oral and Fecal Microbiota in Patients with Axial Spondyloarthritis
Tejpal Gill¹, Patrick Stauffer¹, Mark Asquith¹, Ted Laderas¹, Tammy Martin², Sean Davin¹, Claire Ramirez¹, Ingrid Lindquist¹, Justine Nguyen¹, stephen Planck¹, Carley Shaut¹, Sarah Diamond¹, James T. Rosenbaum³ and Lisa Karstens¹, ¹Oregon Health & Science University, Portland, OR, ²Departments of Ophthalmology, and Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, OR, ³Departments of Ophthalmology, Medicine, and Cell Biology, Oregon Health & Sciences University and Chair Emeritus, Legacy Devers Eye Institute, Portland, OR
Background/Purpose: Axial spondyloarthritis (AxSpA) is immune-mediated inflammatory arthritis, which affects the sacroiliac and spinal joints, and is associated with gut inflammation. Disease pathogenesis is associated…
Abstract Number: 073 • Pediatric Rheumatology Symposium 2020
Differences in Clinical Presentation Between Israeli and United States Children with Juvenile Spondyloarthritis
Nassem Ghantous¹, Merav Heshin Bekenstein ², Kimberly DeQuattro ³, Yaniv Lakovsky ⁴, amir hendel ⁵, Nadav Rappoport ⁶, Yonatan Butbul Aviel ⁷, Irit Tirosh ⁸, Liora Harel ⁹, Pamela Weiss ¹⁰, Lianne Gensler ¹¹ and Gil Amarilyo ¹², ¹Sackler School of Medicine, Tel Aviv University, Sakhnin, Israel, ²Dana Children’s Hospital of Tel Aviv Medical Center, Binyamina, Israel, ³UCSF, San Francisco, ⁴Schneider Children's Hospital, Petach Tikva, Israel, ⁵tel aviv university, kibbutz lohame hagetaot, Israel, ⁶Ben-Gurion University of the Negev, Beer-Sheva, Israel, ⁷Rambam Medical center, Haifa, Hefa, Israel, ⁸, ⁹Schneider Hospital, Tel Aviv University, Petah-Tiqva, Israel, ¹⁰Children's Hospital of Philadelphia, Philadelphia, ¹¹University of California San Francisco, San Francisco, ¹²Schneider Hospital, Tel Aviv University, Kibbutz Magal, Israel
Background/Purpose: Observations among Israeli pediatric rheumatologists reveal pediatric Juvenile Spondyloarthritis (JSpA) may present differently compared to patients from the United States (US). This study aimed…