Abstracts tagged "histopathologic"

Abstract Number: 2136 • 2016 ACR/ARHP Annual Meeting
CD14 Deficiency Delays Progression of Cartilage Degeneration and Protects Against Early Deficits in Functional Outcomes in a Murine Osteoarthritis Model
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Ryan Smalley^2,3, George R. Dodge^3,4 and Carla R. Scanzello^1,2,3, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³Department of Orthopedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Research, CMC Veterans Affairs Medical Center, Philadelphia, PA
Background/Purpose: CD14, though expressed by multiple cell types, is highly expressed by monocytes and macrophages. It forms a complex with Toll-like receptors (TLRs), particularly TLR-2…
Abstract Number: 2138 • 2016 ACR/ARHP Annual Meeting
Transcriptional Analysis of Synovial Tissue Reveals Sustained Inflammatory Chemokine Expression Despite Minimal Histopathologic Change in the Destabilization of Medial Meniscus Model of Murine Knee Osteoarthritis
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Jason G. Lieberthal³, George R. Dodge^4,5 and Carla R. Scanzello^1,2,5, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³Internal Medicine, Mount Auburn Hospital, Cambridge, MA, ⁴Research, CMC Veterans Affairs Medical Center, Philadelphia, PA, ⁵Department of Orthopedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: The destabilization of medial meniscus (DMM) model of instability-induced OA replicates disease-related tissue pathology (including cartilage erosion, osteophytosis) and pain-related joint dysfunction, making it…
Abstract Number: 2355 • 2016 ACR/ARHP Annual Meeting
Histology of Bone Marrow Lesions in Osteoarthritis: A Systematic Literature Review
S. van Beest¹, F.P.B. Kroon¹, W. Damman¹, J.W. Schoones², A. Ioan-Facsinay¹ and M. Kloppenburg³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Walaeus Library, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Bone marrow lesions (BMLs) are of high interest in osteoarthritis for their association with pain and structural progression. They are characterized on magnetic resonance…
Abstract Number: 2838 • 2016 ACR/ARHP Annual Meeting
Histopatholgic Predictors of Poor Renal Outcomes in a Multi-Ethnic Cohort
Stacy Tanner¹, Dominick Santoriello², Shanthi Dhaduvai³, Thania Perez⁴, Anca D. Askanase⁵ and Laura Geraldino-Pardilla⁶, ¹Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Renal Pathology, Columbia University College of Physicians & Surgeons, New York, NY, ³Rheumatology, Carilion Clinic, Roanoke, VA, ⁴Columbia University College of Physicians & Surgeons, New York, NY, ⁵Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁶Columbia University College of Physicians & Surgeons, new york, NY
Background/Purpose: Lupus nephritis (LN) remains an important cause of morbidity and mortality in patients with SLE. Tubular atrophy and interstitial fibrosis on initial renal biopsies…
Abstract Number: 1915 • 2015 ACR/ARHP Annual Meeting
Pathogenetic Overlap Between Localised and Systemic Scleroderma: A Study of Nodular and Keloidal Morphea Occurring in Systemic Sclerosis
Emma C. Derrett-Smith¹, Nataliya Gak², Svetlana I. Nihtyanova³, Voon H. Ong³, Victoria Swale², Cate Orteu² and Christopher P. Denton⁴, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Division of Medicine, London, United Kingdom, ²Royal Free London NHS Foundation Trust, London, United Kingdom, ³Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Localised scleroderma can occur in overlap with systemic sclerosis (SSc); nodular and keloidal morphea are rare subtypes but can be disfiguring and challenging to…
Abstract Number: 2159 • 2015 ACR/ARHP Annual Meeting
Second Temporal Artery Biopsies in Patients with Temporal Arteritis (TA)
John Fritzlen¹, Brian Younge², Cornelia M. Weyand³, Gene G. Hunder⁴, Jorg Goronzy⁵, Kenneth J. Warrington⁴ and Joseph Maleszewski¹, ¹Anatomical Pathology, Mayo Clinic, Rochester, MN, ²Ophthalmology, Mayo Clinic, Rochester, MN, ³Stanford, Stanford, CA, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, Atlanta, GA
Background/Purpose: While many manifestations of TA improve quickly after starting glucocorticoid therapy, vascular inflammation appears to persist. To obtain more information about the duration of…
Abstract Number: 3179 • 2015 ACR/ARHP Annual Meeting
Diagnosing Childhood Small Vessel CNS Vasculitis
Marinka Twilt¹, Maryam Nabavi Nouri², Pascal N. Tyrrell³, Anastasia Dropol¹, Shehla Sheikh⁴, Cynthia Hawkins⁵ and Susanne Benseler^6,7, ¹Rheumatology, Alberta Children's Hospital, Calgary, AB, Canada, ²Neurology, The Hospital for Sick Childern, Toronto, ON, Canada, ³Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Alberta Children's Hospital Research Institute/University of Calgary, Calgary, AB, Canada, ⁷Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada
Background/Purpose: Childhood primary small vessel CNS vasculitis (SVcPACNS) is an increasingly recognized inflammatory brain disease with high morbidity and mortality mandating an elective brain biopsy…
Abstract Number: 407 • 2015 ACR/ARHP Annual Meeting
Inter-Observer Variability of the Histological Classification of Lupus Glomerulonephritis in Children
Louise Oni¹, Michael Beresford², David Witte³, Anastasios Chatzitolios⁴, Neil Sebire⁵, Rajeev Shukla⁶, Jun Ying⁷ and Hermine I. Brunner⁸, ¹Department of Paediatric Nephrology, Alder Hey Children's Hospital, Liverpool UK, Liverpool, England, ²University of Liverpool, Institute of Translational Medicine (Child Health), Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Department of Histopathology, Southmead Hospital, Bristol, UK, Bristol, England, ⁵Department of Paediatric Histopathology, Great Ormond Street Hospital for Children NHS Trust, London, England, ⁶Department of Paediatric Histopathology, Alder Hey Children's Hospital, Liverpool UK, Liverpool, England, ⁷Center for Biostatistical Services, University of Cincinnati College of Medicine, Cincinnati, OH, ⁸Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: The gold standard for diagnosis and classification of lupus nephritis (LN) is according to the renal histology. The inter-observer reliability between histologists is variable.…
Abstract Number: 798 • 2014 ACR/ARHP Annual Meeting
Frequency and Predictive Variables of Relapses in Patients with Biopsy-Proven Giant Cell Arteritis
Luigi Boiardi¹, Giovanna Restuccia², Francesco Muratore¹, Alberto Cavazza³, Luca Cimino⁴, Raffaella Aldigeri⁵, Pierluigi Macchioni¹, Maria Grazia Catanoso⁶, Nicolò Pipitone¹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical and experimental Medicine, Università di parma, Parma, Italy, ⁶Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Relapses and recurrences of…
Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting
Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients
Surjeet Singh¹, Andrew Hutchings², Wulf Forrester-Barker³, Bhaskar Dasgupta⁴, Andreas P. Diamantopoulos⁵, Peter Lanyon⁶, Malgorzata Magliano⁷, Brendan McDonald⁸, Konrad Wolfe⁹ and Raashid Luqmani¹⁰, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ³University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ⁴Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁵Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁶Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ⁷Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, ⁸Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, ⁹Department of Pathology, Southend University Hospital, Essex, United Kingdom, ¹⁰Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
Abstract Number: 134 • 2014 ACR/ARHP Annual Meeting
Histopathological Correlation of Ultrasound-Defined Active Synovitis in Patients with Rheumatoid Arthritis in Clinical Remission. Preliminary Results
Julio Ramirez¹, Virginia Ruiz-Esquide¹, Raquel Celis², Alicia Usategui³, Regina Faré⁴, Andrea Cuervo¹, Sonia Cabrera-Villalba⁵, Maria Victoria Hernández⁶, Jose Inciarte-Mundo¹, Jose L. Pablos⁴, Raimon Sanmarti⁷ and Juan D. Cañete⁵, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ⁵Rheumatology, Hospital Clinic, Barcelona, Spain, ⁶Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, ⁷Rheumatology, Clinic Hospital, Barcelona, Spain
Background/Purpose We recently demonstrated that 45.4% of patients with RA in clinical remission have ultrasound (US)-defined active synovitis (synovial hypertrophy (HS) grade 2 or higher…

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