Abstracts tagged "histopathologic"

Abstract Number: 153 • 2016 ACR/ARHP Annual Meeting
Synovial Immunophenotype and Ultrasonography: A Contemporaneous Study of Different Compartments of the Knee Joint
Aurélie Najm^1,2, Carl Orr³, Benoît Le Goff MD PhD¹, Ursula Fearon⁴ and Douglas J. Veale⁵, ¹Rheumatology, Nantes University Hospital, Nantes, France, ²Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁴Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, ⁵Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland
Background/Purpose: Histological analysis of synovial tissue, despite being a reliable and accurate assessment for synovitis, is not routinely performed. Ultrasonography (US) is a fast, available…
Abstract Number: 156 • 2016 ACR/ARHP Annual Meeting
Detection of Finger Joint Osteophytes and Bone Erosions By Ultrasound; A Comparison to Computed Tomography and Histology
Martin Stradner¹, Stephanie Finzel², Rusmir Husic¹, Manuel Dreu³, Alexander Hofmeister⁴, christine Beham-Schmid⁵, Winfried Graninger¹ and Christian Dejaco¹, ¹Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Department of Rheumatology and Clinical Immunology, Medical Faculty, University Medical Center, University of Freiburg, Freiburg, Germany, ³Department of Anatomy, Medical University of Graz, Graz, Austria, ⁴Core Facility Alternative Biomodels & Preclinical Imaging, Medical University of Graz, Graz, Austria, ⁵5Institute of Pathology, Medical University of Graz, Graz, Austria
Background/Purpose: Ultrasound (US) is an emerging technique for the examination of osteoarthritis of the hands (HOA).Bone erosions and osteophytes are hallmarks of advanced HOA. We…
Abstract Number: 1576 • 2016 ACR/ARHP Annual Meeting
Identifying Rheumatoid Arthritis Subtypes Using Synovial Tissue Gene Expression Profiling, Histologic Scoring and Clinical Correlates
Dana E. Orange¹, Susan M. Goodman², Phaedra Agius³, Ryan Cummings⁴, Kathleen Andersen¹, Robert Darnell⁵, Lionel Ivashkiv², Alessandra B. Pernis⁶, Edward F. DiCarlo⁷, Vivian P. Bykerk⁸ and Laura T. Donlin⁹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medicine, Hospital for Special Surgery, New York, NY, ³New York Genome Center, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵The New York Genome Center, New York, NY, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁷Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁸Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ⁹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: The histopathologic features of synovial tissue vary widely among patients with rheumatoid arthritis (RA) undergoing arthroplasty and the clinical significance of this variability is…
Abstract Number: 1959 • 2016 ACR/ARHP Annual Meeting
How Do Bone Marrow Lesions Cause Osteoarthritis Pain? a Structural and Functional Tissue-Based Study
Nidhi Sofat¹, Lena Assi², Anasuya Kuttapitiya³, Alan Boyde⁴, Vivian Ejindu⁵ and Christine Heron⁵, ¹Basic Medical Sciences, St. George's, University of London, London, United Kingdom, ²St George's University of London, Institute for Infection & Immunity, London, United Kingdom, ³St George's, University of London, Institute for Infection & Immunity, London, United Kingdom, ⁴Queen Mary University of London, London, United Kingdom, ⁵Department of Radiology, St George's Hospital, London, United Kingdom
Background/Purpose: Bone marrow lesions (BML) are well described in osteoarthritis (OA) and associate with pain, but little is known about histological and functional features of…
Abstract Number: 407 • 2015 ACR/ARHP Annual Meeting
Inter-Observer Variability of the Histological Classification of Lupus Glomerulonephritis in Children
Louise Oni¹, Michael Beresford², David Witte³, Anastasios Chatzitolios⁴, Neil Sebire⁵, Rajeev Shukla⁶, Jun Ying⁷ and Hermine I. Brunner⁸, ¹Department of Paediatric Nephrology, Alder Hey Children's Hospital, Liverpool UK, Liverpool, England, ²University of Liverpool, Institute of Translational Medicine (Child Health), Alder Hey Children's Foundation NHS Trust, Liverpool, United Kingdom, ³Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ⁴Department of Histopathology, Southmead Hospital, Bristol, UK, Bristol, England, ⁵Department of Paediatric Histopathology, Great Ormond Street Hospital for Children NHS Trust, London, England, ⁶Department of Paediatric Histopathology, Alder Hey Children's Hospital, Liverpool UK, Liverpool, England, ⁷Center for Biostatistical Services, University of Cincinnati College of Medicine, Cincinnati, OH, ⁸Pediatric Rheumatology Collaborative Study Group, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: The gold standard for diagnosis and classification of lupus nephritis (LN) is according to the renal histology. The inter-observer reliability between histologists is variable.…
Abstract Number: 1915 • 2015 ACR/ARHP Annual Meeting
Pathogenetic Overlap Between Localised and Systemic Scleroderma: A Study of Nodular and Keloidal Morphea Occurring in Systemic Sclerosis
Emma C. Derrett-Smith¹, Nataliya Gak², Svetlana I. Nihtyanova³, Voon H. Ong³, Victoria Swale², Cate Orteu² and Christopher P. Denton⁴, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Division of Medicine, London, United Kingdom, ²Royal Free London NHS Foundation Trust, London, United Kingdom, ³Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Localised scleroderma can occur in overlap with systemic sclerosis (SSc); nodular and keloidal morphea are rare subtypes but can be disfiguring and challenging to…
Abstract Number: 2159 • 2015 ACR/ARHP Annual Meeting
Second Temporal Artery Biopsies in Patients with Temporal Arteritis (TA)
John Fritzlen¹, Brian Younge², Cornelia M. Weyand³, Gene G. Hunder⁴, Jorg Goronzy⁵, Kenneth J. Warrington⁴ and Joseph Maleszewski¹, ¹Anatomical Pathology, Mayo Clinic, Rochester, MN, ²Ophthalmology, Mayo Clinic, Rochester, MN, ³Stanford, Stanford, CA, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Emory University School of Medicine, Lowance Center for Human Immunology and Rheumatology, Atlanta, GA
Background/Purpose: While many manifestations of TA improve quickly after starting glucocorticoid therapy, vascular inflammation appears to persist. To obtain more information about the duration of…
Abstract Number: 3179 • 2015 ACR/ARHP Annual Meeting
Diagnosing Childhood Small Vessel CNS Vasculitis
Marinka Twilt¹, Maryam Nabavi Nouri², Pascal N. Tyrrell³, Anastasia Dropol¹, Shehla Sheikh⁴, Cynthia Hawkins⁵ and Susanne Benseler^6,7, ¹Rheumatology, Alberta Children's Hospital, Calgary, AB, Canada, ²Neurology, The Hospital for Sick Childern, Toronto, ON, Canada, ³Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Alberta Children's Hospital Research Institute/University of Calgary, Calgary, AB, Canada, ⁷Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada
Background/Purpose: Childhood primary small vessel CNS vasculitis (SVcPACNS) is an increasingly recognized inflammatory brain disease with high morbidity and mortality mandating an elective brain biopsy…
Abstract Number: 798 • 2014 ACR/ARHP Annual Meeting
Frequency and Predictive Variables of Relapses in Patients with Biopsy-Proven Giant Cell Arteritis
Luigi Boiardi¹, Giovanna Restuccia², Francesco Muratore¹, Alberto Cavazza³, Luca Cimino⁴, Raffaella Aldigeri⁵, Pierluigi Macchioni¹, Maria Grazia Catanoso⁶, Nicolò Pipitone¹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical and experimental Medicine, Università di parma, Parma, Italy, ⁶Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Relapses and recurrences of…
Abstract Number: 793 • 2014 ACR/ARHP Annual Meeting
Preliminary Analysis of Histological Findings in Diagnosis of Giant Cell Arteritis Biopsy Positive Patients
Surjeet Singh¹, Andrew Hutchings², Wulf Forrester-Barker³, Bhaskar Dasgupta⁴, Andreas P. Diamantopoulos⁵, Peter Lanyon⁶, Malgorzata Magliano⁷, Brendan McDonald⁸, Konrad Wolfe⁹ and Raashid Luqmani¹⁰, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom, ³University of Oxford, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ⁴Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁵Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ⁶Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ⁷Department of Rheumatology,, Stoke Mandeville Hospital, Aylesbury, United Kingdom, ⁸Department of Pathology, John Radcliffe Hospital, Oxford, United Kingdom, ⁹Department of Pathology, Southend University Hospital, Essex, United Kingdom, ¹⁰Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom
Background/Purpose A positive temporal artery biopsy (TAB) with giant cells, active inflammation and intimal hyperplasia is the gold standard test for diagnosing temporal arteritis. However,…
Abstract Number: 134 • 2014 ACR/ARHP Annual Meeting
Histopathological Correlation of Ultrasound-Defined Active Synovitis in Patients with Rheumatoid Arthritis in Clinical Remission. Preliminary Results
Julio Ramirez¹, Virginia Ruiz-Esquide¹, Raquel Celis², Alicia Usategui³, Regina Faré⁴, Andrea Cuervo¹, Sonia Cabrera-Villalba⁵, Maria Victoria Hernández⁶, Jose Inciarte-Mundo¹, Jose L. Pablos⁴, Raimon Sanmarti⁷ and Juan D. Cañete⁵, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ⁵Rheumatology, Hospital Clinic, Barcelona, Spain, ⁶Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, ⁷Rheumatology, Clinic Hospital, Barcelona, Spain
Background/Purpose We recently demonstrated that 45.4% of patients with RA in clinical remission have ultrasound (US)-defined active synovitis (synovial hypertrophy (HS) grade 2 or higher…

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