Abstracts tagged "Histone Modification and SLE"

Abstract Number: 1758 • 2015 ACR/ARHP Annual Meeting
Alterations in Nuclear Structure Promote Lupus Autoimmunity in a Mouse Model
Namrata Singh¹, Duncan Johnstone², Kayla Martin³, Italo Tempera⁴, Mariana J. Kaplan⁵ and Michael Denny⁶, ¹Internal Medicine, University of Iowa, Iowa City, IA, ²Nephrology, Internal Medicine, Temple University School of Medicine, Philadelphia, PA, ³Microbiology and Immunology, Temple University, Philadelphia, PA, ⁴Micorbiology/Immunology, Fels Institute for Cancer Research, Philadelphia, PA, ⁵Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁶Internal Medicine, Temple University School of Medicine, Philadelphia, PA
Background/Purpose: SLE is regarded as a failure of the immune system to maintain tolerance to self-antigens. Despite steady advances defining the importance of inflammatory mediators…

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Abstracts tagged "Histone Modification and SLE"

Alterations in Nuclear Structure Promote Lupus Autoimmunity in a Mouse Model