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Abstracts tagged "Histone Modification and rheumatoid arthritis (RA)"

  • Abstract Number: 45 • ACR/ARHP Annual Meeting 2018

    CKD-506, First-in-Class Histone Deacetylase (HDAC) 6 Inhibitor, Ameliorates Rheumatoid Arthritis through Regulation of Inflammation and T Cell Function

    Jieun Shin1, Nina Ha1, Daekwon Bae1, Dong-Hyeon Suh1, Ji-yeon Baek1, Jae Hyun Jun1, Yong Jae Lee1, Changsik Lee1, Sei-Hwan Kim1, Young Il Choi1, Keun Ho Ryu1, Yu Jin Jang2, Sehui Shon2, Yeong Wook Song3, Gi Soo Youn4 and Jinseu Park4, 1Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), 2Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea, Republic of (South), 3Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 4Department of Biomedical Science, Hallym University, Chuncheon, Korea, Republic of (South)

    Background/Purpose: Broad-spectrum histone deacetylase inhibitors are well known for immunomodulatory functions. However, due to their toxicity, HDAC subtype specific inhibition has been proposed as therapeutic…

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