Abstracts tagged "Histone Modification and rheumatoid arthritis (RA)"

Abstract Number: 45 • 2018 ACR/ARHP Annual Meeting
CKD-506, First-in-Class Histone Deacetylase (HDAC) 6 Inhibitor, Ameliorates Rheumatoid Arthritis through Regulation of Inflammation and T Cell Function
Jieun Shin¹, Nina Ha¹, Daekwon Bae¹, Dong-Hyeon Suh¹, Ji-yeon Baek¹, Jae Hyun Jun¹, Yong Jae Lee¹, Changsik Lee¹, Sei-Hwan Kim¹, Young Il Choi¹, Keun Ho Ryu¹, Yu Jin Jang², Sehui Shon², Yeong Wook Song³, Gi Soo Youn⁴ and Jinseu Park⁴, ¹Research Institute of Chong Kun Dang Pharmaceutical Corporation, Yongin, Korea, Republic of (South), ²Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea, Republic of (South), ³Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁴Department of Biomedical Science, Hallym University, Chuncheon, Korea, Republic of (South)
Background/Purpose: Broad-spectrum histone deacetylase inhibitors are well known for immunomodulatory functions. However, due to their toxicity, HDAC subtype specific inhibition has been proposed as therapeutic…

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