Abstracts tagged "heart disease and systemic sclerosis"

Abstract Number: 1926 • 2017 ACR/ARHP Annual Meeting
Cardiac Remodeling in Systemic Sclerosis: TGF-β/Fra2-Dependent Autophagy As a Novel Target for Heart Fibrosis
Mara Stellato¹, Michal Rudnik¹, Florian Renoux¹, Elena Pachera¹, Karl Sotlar², Karin Klingel³, Joerg C. Henes⁴, Przemyslaw Blyszczuk^1,5, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ³Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁴Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland
Background/Purpose: SSc patients frequently suffer from primary cardiac involvement. The main histological feature is fibrosis, but the mechanisms responsible for the heart failure remain unclear.…
Abstract Number: 3178 • 2016 ACR/ARHP Annual Meeting
Heart Dysfunction in Systemic Sclerosis: Involvement of a Novel Fibrogenic Stromal Cell Subset
Mara Stellato¹, Michal Rudnik¹, Florian Renoux², Elena Pachera¹, Karl Sotlar³, Karin Klingel⁴, Joerg C. Henes⁵, Przemyslaw Blyszczuk⁶, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, ³Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Cardiac dysfunction is a significant cause of the high mortality in systemic sclerosis (SSc). Heart involvement in SSc patients resembles inflammatory dilated cardiomyopathy (iDCM)…
Abstract Number: 847 • 2015 ACR/ARHP Annual Meeting
Troponin T and NT-Probnp Are Prognostic Cardiac Disease Biomarkers in Patients with Systemic Sclerosis without Pulmonary Arterial Hypertension
Silvia Laura Bosello¹, Giacomo De Luca¹, Franca Forni², Clara Di Mario³, Federico parisi¹, Giovanni Canestrari¹, Giorgia Berardi¹, Manuela Rucco¹, Francesca Gabrielli⁴, Leonarda Galiuto⁴, Francesco Loperfido⁴ and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ²Department of Laboratory Medicine, Catholic University of the Sacred Heart, Rome, Italy, ³Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ⁴Division of Heart Failure and Cardiac Rehabilitation, Catholic University - Rome, Rome, Italy
Background/Purpose: Heart involvement is common in Systemic Sclerosis (SSc), even if often clinically silent, and represents one of the leading cause of death in these…
Abstract Number: 850 • 2015 ACR/ARHP Annual Meeting
Incidence and Predictors of Severe Heart Disease in Systemic Sclerosis
Serena Vettori¹, Yannick Allanore², Laszlo Czirjak³, Francesco Del Galdo⁴, Christopher P. Denton⁵, Oliver Distler⁶, Ivan Foeldvari⁷, Marc Frerix⁸, Veronika K. Jaeger⁹, Brigitte Krummel-Lorenz¹⁰, Marco Matucci Cerinic¹¹, Carina Mihai¹², Ulf Müller-Ladner¹³, Gabriela Riemekasten¹⁴, Tim Schmeiser¹⁵, Ingo H. Tarner⁸, Ulrich A. Walker⁹, Gabriele Valentini¹⁶ and EUSTAR Group and DeSScipher Consortium, ¹Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ³Rheumatology and Immunology Medical School, University of Pécs, Pécs, Hungary, ⁴Division of Musculoskeletal Diseases, University of Leeds, Leeds, United Kingdom, ⁵Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁶Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, ⁸Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ¹⁰Rheumatologist, Frankfurt, Germany, ¹¹Department of Internal Medicine, Division of Rheumatology, University of Florence, Florence, Italy, ¹²Internal Medicine and Rheumatology Departement, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Bucharest, Romania, ¹³Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ¹⁴Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Berlin, Germany, ¹⁵Internistic Rheumatology, Krankenhaus St. Josef, Wuppertal, Germany, ¹⁶Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: Heart disease occurs in most patients with systemic sclerosis (SSc), as emerged by autopsy and imaging studies. It can cause cardiac blocks (CBs), ventricular…
Abstract Number: 2965 • 2015 ACR/ARHP Annual Meeting
Might Troponin be a Marker for Subclinical Scleroderma Heart Involvement (SHI)?
Chiara Stagnaro¹, Anna d'Ascanio¹, Alice Parma², Umberto Conti³, Michele Emdin⁴, Alessandra Della Rossa¹ and Marta Mosca¹, ¹Internal Medicine, University of Pisa, Pisa, Italy, ²University of Pisa, Pisa, Italy, ³Cardiotoracico, Cardiologia 2, Pisa, Italy, ⁴Fondazione Toscana Gabriele Monasterio, UOC Cardiologia e Medicina Cardiovascolare, Pisa, Italy
Background/Purpose: Systemic sclerosis (SSc) is a rare connective tissue disease with pronounced alterations of the microvascular system, frequent cellular and humoral immunity abnormalities and fibroblast…
Abstract Number: 3138 • 2015 ACR/ARHP Annual Meeting
Prognostic Role of Ventricular Ectopic Beats in Systemic Sclerosis
Giacomo De Luca¹, Silvia Laura Bosello¹, Francesca Gabrielli², Giorgia Berardi¹, Federico parisi¹, Manuela Rucco¹, Giovanni Canestrari¹, Leonarda Galiuto³, Filippo Crea³, Francesco Loperfido² and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ²Division of Heart Failure and Cardiac Rehabilitation, Catholic University - Rome, Rome, Italy, ³Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Heart involvement is common during Systemic Sclerosis (SSc), even if often clinically silent, and represents the leading cause of death in about one third…
Abstract Number: 1696 • 2014 ACR/ARHP Annual Meeting
Left Atrial Area Measurement Is Useful for Evaluating Left Ventricular Diastolic Dysfunction Coexisting with Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
Sumiaki Tanaka¹, Nobuhiro Sho², Tatsuo Nagai³, Yoshiyuki Arinuma² and Shunsei Hirohata¹, ¹Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ²Kitasato University School of Medicine, Sagamihara, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) is a crucial organ involvement affecting survival of patients with connective tissue disease (CTDs), such as systemic sclerosis (SSc), systemic…
Abstract Number: 725 • 2014 ACR/ARHP Annual Meeting
Reduced Diffusing Capacity of Carbon Monoxide Is Independently Associated with Worse Subclinical Left Ventricular Function on Speckle-Tracking Echocardiography in Systemic Sclerosis
Monique Hinchcliff¹, Vistasp Daruwalla², Lauren Beussink-Nelson³, Sofia Podlusky⁴, Mary A. Carns⁴, John Varga⁵, Michael Cuttica⁶ and Sanjiv J. Shah⁷, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Internal Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Reduced diffusing capacity of carbon monoxide (DLCO) is a predictor of worse outcomes in patients with systemic sclerosis (SSc). Traditionally, the association between low…

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