ACR Meeting Abstracts

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Abstracts tagged "heart block"

  • Abstract Number: 1761 • 2019 ACR/ARP Annual Meeting

    The Prospective Open Label Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH) Study Demonstrates a Reduction in the Recurrence Rate of Advanced Block

    Peter Izmirly1, Mimi Kim 2, Nathalie Costedoat-Chalumeau 3, Deborah Friedman 4, Amit Saxena 5, Joshua Copel 6, Rebecca Cohen 1, Mala Masson 1, Tishaun Middleton 1, Kimberly Robins 1, Robert Clancy 1 and Jill Buyon 1, 1NYU School of Medicine, New York, 2Albert Einstein College of Medicine, Bronx, NY, 3Cochin University Hospital, Paris, France, 4New York Medical College, Valhalla, 5New York University School of Medicine, New York, NY, 6Yale School of Medicine, New Haven

    Background/Purpose: Based on encouraging bench to bedside results including experimental evidence supporting Toll-like receptor signaling in the pathogenesis of CHB, a case control study demonstrating…
  • Abstract Number: 2866 • 2019 ACR/ARP Annual Meeting

    Factors Associated with Cardiac Dysfunction in a Longitudinal Follow-Up of Neonatal Lupus

    Amit Saxena1, Peter Izmirly 2, Rebecca Bomar 3, Shireen Golpanian 4, Deborah Friedman 5, Ruth Eisenberg 6, Mimi Kim 7 and Jill Buyon 2, 1New York University School of Medicine, New York, NY, 2NYU School of Medicine, New York, 3New York University School of Medicine, New York, NY, New York, 4Miami Miller School of Medicine, Miami, 5New York Medical College, Valhalla, 6Albert Einstein College of Medicine, New York, 7Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality, however there has been minimal information on long-term outcomes of…
  • Abstract Number: 164 • 2017 ACR/ARHP Annual Meeting

    Association of Natural Killer Cell Ligand Polymorphism, HLA-C Asn80Lys, with the Development of Anti-SSA/Ro Associated Congenital Heart Block

    Hannah C. Ainsworth1, Miranda C Marion1, Antonio Brucato2, Nathalie Costedoat-Chalumeau3, Tiziana Bertero4, Rolando Cimaz5, Micaela Fredi6, Patrick M. Gaffney7, Jennifer A. Kelly7, Kateri Levesque8, Alice Maltret8, Nathalie Morel8, Véronique Ramoni9, Amelia Ruffatti10, Carl D Langefeld1, Jill P. Buyon11 and Robert M Clancy11, 1Wake Forest University, Winston Salem, NC, 2Ospedale Papa Giovanni XXIII, Bergamo, Italy, 3Service de médecine interne Pôle médecine, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares de l’île de France, Paris, France, 4Ospedale Mauriziano, Torino, Italy, 5Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, 6Department of Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, 7Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Université Paris Descartes-Sorbonne Paris Cité, Paris, France, 9Ospedale Papa Giovanni XXIII of Bergamo, Policlinico San Matteo of Pavia, Bergamo, Pavia, Italy, 10Unità di Reumatologia, Dipartimento di Medicina-DIMED, Università di Padova., Padova, Italy, 11NYU Langone Medical Center, New York, NY

    Background/Purpose: Fetal exposure to maternal anti-SSA/Ro antibodies is necessary but insufficient for the development of congenital heart block (CHB), suggesting the potential of a fetal…
  • Abstract Number: 941 • 2017 ACR/ARHP Annual Meeting

    Ro/SSA Autoantibody Exposed Neonates Have an Expansion of NK Cells and a Discernible Type II IFN Signature with High IFNγ in Peripheral Blood

    Margarita Ivanchenko1, Malin Hedlund1, Gudny Ella Thorlacius1, Vijole Ottosson1, Karine Chemin2, Sven-Erik Sonesson3 and Marie Wahren-Herlenius1, 1Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 3Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Congenital heart block (CHB) may develop in the fetus of women with Ro/SSA autoantibodies. The mothers are commonly diagnosed with Sjögren’s syndrome or SLE.…
  • Abstract Number: 1061 • 2017 ACR/ARHP Annual Meeting

    Cardiac Endothelial Cell Transcriptome Analyses Support a Pathological Role of Metabolic and Inflammasome Genes in Anti-SSA/Ro-Associated Congenital Heart Block

    Sara Rasmussen1, Robert M. Clancy2 and Jill P. Buyon2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: The role of Type I IFN in anti-SSA/Ro-associated Congenital Heart Block (CHB) may include an adverse consequence to the cardiac vasculature. One scenario consistent…
  • Abstract Number: 2817 • 2017 ACR/ARHP Annual Meeting

    Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero

    Gudny Ella Thorlacius1, Malin Hedlund1, Margarita Ivanchenko1, Vijole Ottosson1, Amina Ossoinak1, Linda Lagnefeldt1, Lars Rönnblom2, Sven-Erik Sonesson3, Maija-Leena Eloranta4 and Marie Wahren-Herlenius1, 1Unit of Experimental Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 3Pediatric Cardiology Unit, Department of Women´s and Children´s Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 4Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden

    Background/Purpose: Women with Sjögren’s syndrome and autoantibodies against Ro/SSA are at risk for pregnancy complications, including neonatal lupus erythematosus (NLE) and a congenital heart block…
  • Abstract Number: 2454 • 2016 ACR/ARHP Annual Meeting

    Cohort of Pregnant Women with Ro/La Antibodies: Risk of Fetal Third Degree Atrioventricular Block and Use of Hydroxychloroquine

    Florencia Beatriz Mollerach1, Marina Scolnik2, Luis J. Catoggio2 and Enrique R. Soriano1, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Argentina., Buenos Aires, Argentina

    Background/Purpose: Third degree atrioventricular block(AVB), a rare congenital complication, duplicate-triplicate frequency up to 2% when Ro/La maternal antibodies are present. Incidence rises to 17-20% in…
  • Abstract Number: 3117 • 2016 ACR/ARHP Annual Meeting

    Development of Autoimmune Diseases and Genetic Predisposition in Children with Neonatal Lupus and Their Unaffected Siblings

    Aaron Garza Romero1, Peter M. Izmirly2, Hannah C. Ainsworth3, Miranda Marion3, Carl Langefeld3, Robert Clancy4, Jill P. Buyon5 and Amit Saxena6, 1Rheumatology, NYU School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3Wake Forest School of Medicine, Winston-Salem, NC, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 5Medicine, New York University School of Medicine, New York, NY, 6Rheumatology, New York University School of Medicine, New York, NY

    Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies.  This study was initiated to address the…
  • Abstract Number: 1059 • 2015 ACR/ARHP Annual Meeting

    Increased Risk of Atrioventricular Block, Atrial Fibrillation and Pacemaker Implantation in Ankylosing Spondylitis, Undifferentiated Spondylarthritis and Psoriatic Arthritis Compared to the General Population

    Karin Bengtsson1, Helena Forsblad-d'Elia2, Elisabeth Lie1, Eva Klingberg1, Mats Dehlin1, Sofia Exarchou3, Ulf Lindström1, Johan Askling4 and Lennart TH Jacobsson1, 1Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, 3Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 4Clinical Epidemiology Unit and Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: There is a known association between conduction disturbances and ankylosing spondylitis (AS). The risk of conduction disturbances in other phenotypes of spondylarthritis (SpA) is…
  • Abstract Number: 2515 • 2015 ACR/ARHP Annual Meeting

    MEK5/ERK5, a Lynchpin of Human Cardiac Fibroblast Transdifferentiation to a Scarring Phenotype in Autoimmune Congenital Heart Block

    Andrew Markham1, Robert Clancy2, Mukundan Attur3 and Jill P. Buyon2, 1Medicine, New York University School of Medicine, New York, NY, 2Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY

    Background/Purpose: Transplacental passage of maternal autoantibodies (Ab) reactive with the SSA/Ro-SSB/La ribonucleoprotein complex is associated with the development of cardiac injury in the fetus passively…
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