Abstracts tagged "GWAS"

Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium
Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus
Raffaella Carlomagno¹, Fangming Liao ¹, JingJing Cao ², Dafna Gladman ³, Marisa Klein-Gitelman ⁴, Andrea Knight ⁵, Deborah Levy ¹, Andrew Paterson ², Zahi Touma ³, Murray Urowitz ³, Declan Webber ¹, Joan Wither ³, Earl D. Silverman ⁶ and Linda Hiraki ⁷, ¹Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, ⁴Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, ⁵SickKids Research Institute, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
Abstract Number: 1017 • 2019 ACR/ARP Annual Meeting
The Integration of Genetic Data, Molecular Pathway Analysis and Differential Expression to Delineate the Impact of Ancestral Differences on Lupus
Katherine Owen¹, Bryce Aidukaitis ¹, Adam Labonte ¹, Michelle Catalina ¹, Prathyusha Bachali ¹, Nicholas Geraci ², Miranda Marion ³, Hannah Ainsworth ⁴, kip Zimmerman ³, Timothy Howard ⁴, Carl Langefeld ⁴, Peter Lipsky ² and Amrie Grammer ⁵, ¹AMPEL Biosolutions and the RILITE research institute, Charlottesville, VA, ²AMPEL BioSolutions, LLC, Charlottesville, VA, ³Wake Forest School of Medicine, Winston-Salem, NC, ⁴Wake Forest School of Medicine, Winston-Salem, ⁵AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of African-Ancestry (AA) experience the…
Abstract Number: 1120 • 2018 ACR/ARHP Annual Meeting
Strong HLA and Novel Non-HLA Associations Identified By Auto-Antibody Subset Analysis of African Americans with Scleroderma from the Genome Research in African American Scleroderma Patients Cohort
Pravitt Gourh¹, Elaine F. Remmers², Theresa Alexander³, Steven Boyden⁴, Nadia D. Morgan⁵, Ami A. Shah⁶, Maureen D. Mayes⁷, Ayo Doumatey², Amy Bentley², Daniel Shriner⁸, Robyn T. Domsic⁹, Thomas A. Medsger Jr.¹⁰, Virginia D. Steen¹¹, Paula S. Ramos¹², Rick Silver¹³, Benjamin D. Korman¹⁴, John Varga¹⁵, Elena Schiopu¹⁶, Dinesh Khanna¹⁷, Vivien Hsu¹⁸, Jessica K. Gordon¹⁹, Lesley Ann Saketkoo²⁰, Heather Gladue²¹, Brynn Kron²², Lindsey A. Criswell²², Chris T. Derk²³, S. Louis Bridges Jr.²⁴, Victoria Shanmugam²⁵, Kathleen D. Kolstad²⁶, Lorinda Chung²⁷, Reem Jan²⁸, Elana J. Bernstein²⁹, Avram Goldberg³⁰, Marcin Trojanowski³¹, Suzanne Kafaja³², Kathleen Maksimowicz-McKinnon³³, Settara C Chandrasekharappa², Adebowale Adeyemo², Charles Rotimi², Fredrick M. Wigley³⁴, Francesco Boin³⁵ and Daniel L. Kastner³⁶, ¹NIAMS-Rheumatology, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³National Institutes of Health, Bethesda, MD, ⁴National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders, Bethesda, MD, ⁵Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁷Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁸National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD, ⁹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹⁰University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹²Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ¹³Rheumatology, Medical University of SC, Charleston, SC, ¹⁴Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ¹⁵Northwestern University, Chicago, IL, ¹⁶University of Michigan, Ann Arbor, MI, ¹⁷Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ¹⁸Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, ¹⁹Rheumatology, Hospital for Special Surgery, New York, NY, ²⁰Tulane, New Orleans, LA, ²¹Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, ²²University of California San Francisco, San Francisco, CA, ²³Rheumatology, University of Pennsylvania, Philadelphia, PA, ²⁴Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ²⁵Rheumatology, The George Washington University, Washington, DC, ²⁶Rheumatology, Stanford University Medical Center, Stanford, CA, ²⁷Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²⁸Medicine, Rheumatology, University of Chicago, Chicago, IL, ²⁹Rheumatology, Columbia University, New York, NY, ³⁰NYU Langone Medical Center, New York, NY, ³¹Boston University, Boston, MA, ³²David Geffen School of Medicine, UCLA, Los Angeles, CA, ³³Rheumatology, Henry Ford Hospital, Detroit, MI, ³⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³⁵Rheumatology, University California, San Francisco, San Francisco, CA, ³⁶Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Anti-fibrillarin (nucleolar, AFA) and anti-topoisomerase I (ATA) autoantibodies are specific to systemic sclerosis (SSc) and are common in African Americans (AA). These autoantibodies define…
Abstract Number: 1135 • 2018 ACR/ARHP Annual Meeting
Genome-Wide Meta-Analysis Identified Two Novel Variants Associated with Hallux Valgus
Liubov Arbeeva¹, Braxton Mitchell², Rebecca D. Jackson³, Michelle S. Yau⁴, Kathleen Ryan⁵, Yvonne M. Golightly⁶, Marian T. Hannan⁷, Amanda Nelson⁸, Joanne M. Jordan⁹ and Marc C. Hochberg², ¹TARC, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Medicine, University of Maryland, Baltimore, MD, ³Ohio State University, Columbus, OH, ⁴Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁵University of Maryland, Baltimore, MD, ⁶Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Institute for Aging Research, Hebrew SeniorLife & Harvard Medical School, Boston, MA, ⁸UNC School of Medicine, Chapel Hill, NC, ⁹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Hallux valgus (HV) is a common foot disorder that is highly heritable. A genome-wide association study (GWAS) conducted in 4,409 Caucasians from the Framingham…
Abstract Number: 1978 • 2018 ACR/ARHP Annual Meeting
Genome Wide Association Studies in SLE Predict E-Genes and Gene Expression Patterns That Inform Ancestral-Specific Molecular Pathways and Targeted Therapies
Katherine Owen¹, Carl Langefeld², Bryce Aidukaitis¹, Adam Labonte¹, Michelle Catalina¹, Prathyusha Bachali¹, Timothy D Howard³, Amrie Grammer¹ and Peter E. Lipsky¹, ¹AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ²Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with an important genetic component. Genome-wide association studies (GWAS) have linked many single nucleotide polymorphisms…
Abstract Number: 2125 • 2018 ACR/ARHP Annual Meeting
Pleiotropy of a Positive Antinuclear Antibody (ANA) Test: A Phewas and GWAS Approach
Vivian Kawai¹, Jonathan Mosley², QiPing Feng¹, Wei-Qi Wei³, Daniel Carranza Leon², Cecilia P. Chung⁴, Andrea Ihegword² and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Medicine, Vanderbilt University Medical Center, Nashville, TN, ³Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: ANAs are almost always present in systemic lupus erythematosus (SLE), but they are also present in ~12-20% of the population. A positive ANA (ANA+)…
Abstract Number: 2246 • 2018 ACR/ARHP Annual Meeting
Insulin: Genetic and Physiological Influences on Human Uric Acid Homeostasis
David B. Mount¹, Tony R. Merriman² and Asim Mandal¹, ¹Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²University of Otago, Dunedin, New Zealand
Background/Purpose: Insulin plays a key role in the genesis of hyperuricemia. In particular, hyperinsulinemia in metabolic syndrome is inversely correlated with urinary uric acid (UA)…
Abstract Number: 68 • 2018 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Identifies rs116199914 As an Intergenic Variant Associated with Carotid Intima-Media Thickness in Spanish Patients with Rheumatoid Arthritis
Raquel Lopez-Mejías¹, Fernanda Genre¹, Sara Remuzgo-Martínez¹, David Carmona^2,3, Verónica Pulito-Cueto¹, Carlos González-Juanatey⁴, Alfonso Corrales¹, Esther Vicente⁵, Jose A. Miranda-Filloy⁶, Beatriz-Segura Tejera⁷, Marco A. Ramírez Huaranga⁸, Verónica Mijares¹, Leticia Lera-Gomez¹, Ricardo Blanco¹, Montserrat Robustillo-Villarino⁹, Javier Rodríguez-Carrio¹⁰, Ana Suárez¹⁰, Mercedes Alperi-López¹¹, Francisco Javier Ballina-García¹², Francisco Javier López Longo¹³, Francisco Javier Narváez¹⁴, Juan José Alegre⁹, Antonio Mera¹⁵, Eva Perez Pampín¹⁶, Antonio Gonzalez¹⁷, Enrique Raya Álvarez¹⁸, Chary López-Pedrera¹⁹, Carmen Gomez Vaquero¹⁴, Alejandro Balsa²⁰, Dora Pascual-Salcedo²⁰, Patricia Carreira²¹, Isidoro Gonzalez-Alvaro⁵, Luis Rodriguez Rodriguez²², Benjamin Fernandez Gutierrez²², Ivan Ferraz-Amaro²³, Santos Castañeda²⁴, Javier Martin³, Javier Llorca²⁵ and Miguel Angel González-Gay^1,26,27, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain, ³Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, ⁴Division of Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain, ⁵Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ⁶Rheumatology Department, Hospital Universitario Lucus Augusti, Lugo, Spain, ⁷Rheumatology Division, Hospital Insular de Gran Canaria, Las Palmas, Spain, ⁸Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ⁹Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ¹⁰Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ¹¹Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ¹²Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹³Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹⁴Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain, ¹⁵Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ¹⁶Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ¹⁷Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁸Rheumatology, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, ¹⁹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²⁰Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ²¹Servicio de Reumatología, Hospital Universitario, Madrid, Spain, ²²Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, ²³Rheumatology Division, Hospital Insular de Gran Canaria, La Laguna, Spain, ²⁴Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ²⁵School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ²⁶School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ²⁷Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Cardiovascular (CV) disease is the most common cause of morbidity and mortality in patients with rheumatoid arthritis (RA) [1, 2]. Traditional CV risk factors…
Abstract Number: 168 • 2017 ACR/ARHP Annual Meeting
Identification of Novel Susceptibility Loci in a Large UK Cohort of Juvenile Idiopathic Arthritis (JIA) Cases
Samantha Smith¹, John Bowes¹, Joanna Cobb², Anne Hinks¹, Sunil Sampath¹, Annie Yarwood¹, Lucy R Wedderburn³, Kimme L. Hyrich⁴ and Wendy Thomson¹, ¹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, Manchester, United Kingdom, ³3Arthritis Research UK Centre for Adolescent Rheumatology, UCL GOS Institute of Child Health, University College London, London, United Kingdom, ⁴Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a group of chronic arthropathies of unknown cause affecting children under 16yrs, and is the most common childhood inflammatory…
Abstract Number: 170 • 2017 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Clinically-Ascertained Gout and Subtypes Identifies Multiple Susceptibility Loci Including Transporter Genes
Hirotaka Matsuo¹, Akiyoshi Nakayama², Hirofumi Nakaoka³, Ken Yamamoto⁴, Masayuki Sakiyama⁵, Amara Shaukat⁶, Yu Toyoda⁷, Yukinori Okada⁸, Yoichiro Kamatani⁹, Masahiro Nakatochi¹⁰, Takahiro Nakamura⁵, Tappei Takada⁷, Hiroshi Nakashima⁵, Seiko Shimizu⁵, Makoto Kawaguchi⁵, Asahi Hishida¹¹, Kenji Wakai¹¹, Blanka Stiburkova¹², Karel Pavelka¹³, Lisa K. Stamp¹⁴, Nicola Dalbeth¹⁵, Tatsuo Hosoya¹⁶, Michiaki Kubo⁹, Hiroshi Ooyama¹⁷, Toru Shimizu¹⁸, Kimiyoshi Ichida¹⁹, Tony R. Merriman²⁰ and Nariyoshi Shinomiya²¹, ¹Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, ²Dept Integrative Physiol, National Defense Med College, Tokorozawa, Japan, ³National Inst Genet, Mishima, Japan, ⁴Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Japan, ⁵National Defense Med College, Tokorozawa, Japan, ⁶Univ Otago, Dunedin, New Zealand, ⁷Univ Tokyo Hosp, Tokyo, Japan, ⁸Osaka University, Osaka, Japan, ⁹Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ¹⁰Nagoya Univ Hosp, Nagoya, Japan, ¹¹Nagoya Univ Grad Sch Med, Nagoya, Japan, ¹²Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic, ¹³Institute of Rheumatology, Prague, Czech Republic, ¹⁴University of Otago, Christchurch, New Zealand, ¹⁵University of Auckland, Auckland, New Zealand, ¹⁶Jikei Univ Sch Med, Tokyo, Japan, ¹⁷Ryougoku East Gate Clin, Tokyo, Japan, ¹⁸Kyoto Industr Health Assoc, Kyoto, Japan, ¹⁹Tokyo Univ Pharmacy Life Sci, Tokyo, Japan, ²⁰Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²¹National Defense Med College, Saitama, Japan
Background/Purpose: We performed a genome-wide association study (GWAS) of gout and its subtypes to identify novel gout loci including those that are subtype-specific. Methods: Putative…
Abstract Number: 182 • 2017 ACR/ARHP Annual Meeting
Genetic Determinants of Fatigue in Primary Sjögren`s Syndrome – a Genome Wide Association Study
Katrine Norheim¹, Andrei Alexsson², Juliana Imgenberg-Kreuz³, Johan Gorgas Brun^4,5, Roland Jonsson⁶, Wan-Fai Ng^7,8, Elke Theander⁹, Thomas Mandl¹⁰, Kathy L. Sivils¹¹, Lars Rönnblom¹², Gunnel Nordmark¹³ and Roald Omdal^5,14, ¹Clinical Immunology Department, Stavanger University Hospital, Stavanger, Norway, ²Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ³Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁴Section for Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, ⁵Department of Clinical Science, University of Bergen, Bergen, Norway, ⁶Department of Clinical Science, Broegelmann Research Laboratory, University of Bergen, Bergen, Norway, ⁷Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ⁸Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, ⁹Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, ¹⁰Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, ¹¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, ¹³Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ¹⁴Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Fatigue is common in primary Sjögren`s syndrome (pSS), but the mechanisms that lead to fatigue are not fully understood. We hypothesized that there is…
Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting
Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing
Aleksander Lenert¹ and David W. Fardo², ¹Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, ²Biostatistics, College of Public Health, University of Kentucky, Lexington, KY
Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
Abstract Number: 1021 • 2017 ACR/ARHP Annual Meeting
GWAS of Gout in Patients with Hyperuricemia Identified Many Possible New Candidate Risk Alleles
Jing Cui¹, Zhi Zhang¹, Elizabeth Karlson² and Daniel H. Solomon², ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Virtually all gout patients have high levels of uric acid in the blood (hyperurincemia, HU), but approximately 80% of patients with HU will never…
Abstract Number: 2341 • 2017 ACR/ARHP Annual Meeting
The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis
Claire Deakin¹, John Bowes², Lucy Marshall¹, Cerise Johnson¹, Gulnara Mamyrova³, Rodolfo Curiel⁴, Kelly A. Rouster-Stevens⁵, Heinrike Schmeling⁶, Adam Huber⁷, Brian M. Feldman⁸, Ann M Reed⁹, Lauren M. Pachman¹⁰, Soumya Raychaudhuri¹¹, Stephen Eyre¹² and Lucy R Wedderburn¹, ¹Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, ²Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ³Rheumatology, George Washington University School of Medicine and Health Sciences, Washington, DC, ⁴Department of Rheumatology, George Washington University, Washington, DC, ⁵Pediatric Rheumatology, Emory Children's Center, Atlanta, GA, ⁶Alberta Children’s Hospital/University of Calgary, Calgary, AB, Canada, ⁷IWK Health Centre, Halifax, NS, Canada, ⁸Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁹Rheumatology, Duke University, Durham, NC, ¹⁰Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ¹¹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ¹²Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease characterized by muscle weakness and rash. Clinical features of JDM are heterogeneous, and can include…
Abstract Number: 2343 • 2017 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Suggests the HLA Class II Region As the Major Susceptibility Locus for IgA Vasculitis
Raquel López-Mejías¹, Sara Remuzgo-Martínez¹, Fernanda Genre¹, Francisco David Carmona², Santos Castañeda³, Belén Sevilla Pérez⁴, Norberto Ortego Centeno⁴, Javier Llorca⁵, Begoña Ubilla¹, Veronica Mijares¹, Trinitario Pina⁶, Jose A. Miranda-Filloy⁷, Antonio Navas Parejo⁸, Diego Argila⁹, Maximiliano Aragües¹⁰, Esteban Rubio-Romero¹¹, Manuel Leon Luque¹², Juan María Blanco Madrigal¹³, Eva Galindez-Agirregoikoa¹³, David Jayne¹⁴, Ricardo Blanco¹, Javier Martin¹⁵ and Miguel Angel González-Gay¹⁶, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Departamento de Genética e Instituto de Biotecnología, University of Granada, Granada, Spain, ³Hospital Universitario La Princesa. IIS-IP. Madrid. Spain, Madrid, Spain, ⁴Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, ⁵Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, ⁶Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ⁷Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, ⁸Nephrology Department, Hospital Universitario San Cecilio, Granada, Spain, ⁹Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, ¹⁰Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, MAdrid, Spain, ¹¹Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, ¹²Rheumatology Department,Hospital Universitario Virgen del Rocío, Sevilla, Spain, ¹³Rheumatology Division, Hospital Universitario de Basurto, Bilbao, Spain, ¹⁴Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ¹⁵Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, ¹⁶Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain
Background/Purpose: Immunoglobulin-A (IgA) vasculitis, also known as Henoch-Schöenlein purpura (HSP), is the most common type of primary small-sized blood vessel leukocytoclastic vasculitis in children, although…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].