ACR Meeting Abstracts

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Abstracts tagged "GWAS"

  • Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium

    Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao 1, JingJing Cao 2, Dafna Gladman 3, Marisa Klein-Gitelman 4, Andrea Knight 5, Deborah Levy 1, Andrew Paterson 2, Zahi Touma 3, Murray Urowitz 3, Declan Webber 1, Joan Wither 3, Earl D. Silverman 6 and Linda Hiraki 7, 1Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, 4Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, 5SickKids Research Institute, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, 7Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada

    Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
  • Abstract Number: 1017 • 2019 ACR/ARP Annual Meeting

    The Integration of Genetic Data, Molecular Pathway Analysis and Differential Expression to Delineate the Impact of Ancestral Differences on Lupus

    Katherine Owen1, Bryce Aidukaitis 1, Adam Labonte 1, Michelle Catalina 1, Prathyusha Bachali 1, Nicholas Geraci 2, Miranda Marion 3, Hannah Ainsworth 4, kip Zimmerman 3, Timothy Howard 4, Carl Langefeld 4, Peter Lipsky 2 and Amrie Grammer 5, 1AMPEL Biosolutions and the RILITE research institute, Charlottesville, VA, 2AMPEL BioSolutions, LLC, Charlottesville, VA, 3Wake Forest School of Medicine, Winston-Salem, NC, 4Wake Forest School of Medicine, Winston-Salem, 5AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of African-Ancestry (AA) experience the…
  • Abstract Number: 2246 • 2018 ACR/ARHP Annual Meeting

    Insulin: Genetic and Physiological Influences on Human Uric Acid Homeostasis

    David B. Mount1, Tony R. Merriman2 and Asim Mandal1, 1Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2University of Otago, Dunedin, New Zealand

    Background/Purpose: Insulin plays a key role in the genesis of hyperuricemia. In particular, hyperinsulinemia in metabolic syndrome is inversely correlated with urinary uric acid (UA)…
  • Abstract Number: 68 • 2018 ACR/ARHP Annual Meeting

    A Genome-Wide Association Study Identifies rs116199914 As an Intergenic Variant Associated with Carotid Intima-Media Thickness in Spanish Patients with Rheumatoid Arthritis

    Raquel Lopez-Mejías1, Fernanda Genre1, Sara Remuzgo-Martínez1, David Carmona2,3, Verónica Pulito-Cueto1, Carlos González-Juanatey4, Alfonso Corrales1, Esther Vicente5, Jose A. Miranda-Filloy6, Beatriz-Segura Tejera7, Marco A. Ramírez Huaranga8, Verónica Mijares1, Leticia Lera-Gomez1, Ricardo Blanco1, Montserrat Robustillo-Villarino9, Javier Rodríguez-Carrio10, Ana Suárez10, Mercedes Alperi-López11, Francisco Javier Ballina-García12, Francisco Javier López Longo13, Francisco Javier Narváez14, Juan José Alegre9, Antonio Mera15, Eva Perez Pampín16, Antonio Gonzalez17, Enrique Raya Álvarez18, Chary López-Pedrera19, Carmen Gomez Vaquero14, Alejandro Balsa20, Dora Pascual-Salcedo20, Patricia Carreira21, Isidoro Gonzalez-Alvaro5, Luis Rodriguez Rodriguez22, Benjamin Fernandez Gutierrez22, Ivan Ferraz-Amaro23, Santos Castañeda24, Javier Martin3, Javier Llorca25 and Miguel Angel González-Gay1,26,27, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 2Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, Granada, Spain, 3Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain, 4Division of Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain, 5Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 6Rheumatology Department, Hospital Universitario Lucus Augusti, Lugo, Spain, 7Rheumatology Division, Hospital Insular de Gran Canaria, Las Palmas, Spain, 8Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 9Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, 10Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, 11Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, 12Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, 13Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 14Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain, 15Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, 16Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, 17Laboratorio Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 18Rheumatology, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 19IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 20Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, 21Servicio de Reumatología, Hospital Universitario, Madrid, Spain, 22Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, 23Rheumatology Division, Hospital Insular de Gran Canaria, La Laguna, Spain, 24Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 25School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 26School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 27Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Cardiovascular (CV) disease is the most common cause of morbidity and mortality in patients with rheumatoid arthritis (RA) [1, 2]. Traditional CV risk factors…
  • Abstract Number: 1120 • 2018 ACR/ARHP Annual Meeting

    Strong HLA and Novel Non-HLA Associations Identified By Auto-Antibody Subset Analysis of African Americans with Scleroderma from the Genome Research in African American Scleroderma Patients Cohort

    Pravitt Gourh1, Elaine F. Remmers2, Theresa Alexander3, Steven Boyden4, Nadia D. Morgan5, Ami A. Shah6, Maureen D. Mayes7, Ayo Doumatey2, Amy Bentley2, Daniel Shriner8, Robyn T. Domsic9, Thomas A. Medsger Jr.10, Virginia D. Steen11, Paula S. Ramos12, Rick Silver13, Benjamin D. Korman14, John Varga15, Elena Schiopu16, Dinesh Khanna17, Vivien Hsu18, Jessica K. Gordon19, Lesley Ann Saketkoo20, Heather Gladue21, Brynn Kron22, Lindsey A. Criswell22, Chris T. Derk23, S. Louis Bridges Jr.24, Victoria Shanmugam25, Kathleen D. Kolstad26, Lorinda Chung27, Reem Jan28, Elana J. Bernstein29, Avram Goldberg30, Marcin Trojanowski31, Suzanne Kafaja32, Kathleen Maksimowicz-McKinnon33, Settara C Chandrasekharappa2, Adebowale Adeyemo2, Charles Rotimi2, Fredrick M. Wigley34, Francesco Boin35 and Daniel L. Kastner36, 1NIAMS-Rheumatology, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders, Bethesda, MD, 5Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 7Rheumatology, University of Texas McGovern Medical School, Houston, TX, 8National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD, 9Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 10University of Pittsburgh, Pittsburgh, PA, 11Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 12Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 13Rheumatology, Medical University of SC, Charleston, SC, 14Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 15Northwestern University, Chicago, IL, 16University of Michigan, Ann Arbor, MI, 17Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 18Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, 19Rheumatology, Hospital for Special Surgery, New York, NY, 20Tulane, New Orleans, LA, 21Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, 22University of California San Francisco, San Francisco, CA, 23Rheumatology, University of Pennsylvania, Philadelphia, PA, 24Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 25Rheumatology, The George Washington University, Washington, DC, 26Rheumatology, Stanford University Medical Center, Stanford, CA, 27Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 28Medicine, Rheumatology, University of Chicago, Chicago, IL, 29Rheumatology, Columbia University, New York, NY, 30NYU Langone Medical Center, New York, NY, 31Boston University, Boston, MA, 32David Geffen School of Medicine, UCLA, Los Angeles, CA, 33Rheumatology, Henry Ford Hospital, Detroit, MI, 34Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 35Rheumatology, University California, San Francisco, San Francisco, CA, 36Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

    Background/Purpose: Anti-fibrillarin (nucleolar, AFA) and anti-topoisomerase I (ATA) autoantibodies are specific to systemic sclerosis (SSc) and are common in African Americans (AA). These autoantibodies define…
  • Abstract Number: 1135 • 2018 ACR/ARHP Annual Meeting

    Genome-Wide Meta-Analysis Identified Two Novel Variants Associated with Hallux Valgus

    Liubov Arbeeva1, Braxton Mitchell2, Rebecca D. Jackson3, Michelle S. Yau4, Kathleen Ryan5, Yvonne M. Golightly6, Marian T. Hannan7, Amanda Nelson8, Joanne M. Jordan9 and Marc C. Hochberg2, 1TARC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 2School of Medicine, University of Maryland, Baltimore, MD, 3Ohio State University, Columbus, OH, 4Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, 5University of Maryland, Baltimore, MD, 6Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Institute for Aging Research, Hebrew SeniorLife & Harvard Medical School, Boston, MA, 8UNC School of Medicine, Chapel Hill, NC, 9Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Hallux valgus (HV) is a common foot disorder that is highly heritable. A genome-wide association study (GWAS) conducted in 4,409 Caucasians from the Framingham…
  • Abstract Number: 1978 • 2018 ACR/ARHP Annual Meeting

    Genome Wide Association Studies in SLE Predict E-Genes and Gene Expression Patterns That Inform Ancestral-Specific Molecular Pathways and Targeted Therapies

    Katherine Owen1, Carl Langefeld2, Bryce Aidukaitis1, Adam Labonte1, Michelle Catalina1, Prathyusha Bachali1, Timothy D Howard3, Amrie Grammer1 and Peter E. Lipsky1, 1AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, 2Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 3Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with an important genetic component. Genome-wide association studies (GWAS) have linked many single nucleotide polymorphisms…
  • Abstract Number: 2125 • 2018 ACR/ARHP Annual Meeting

    Pleiotropy of a Positive Antinuclear Antibody (ANA) Test: A Phewas and GWAS Approach

    Vivian Kawai1, Jonathan Mosley2, QiPing Feng1, Wei-Qi Wei3, Daniel Carranza Leon2, Cecilia P. Chung4, Andrea Ihegword2 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2Medicine, Vanderbilt University Medical Center, Nashville, TN, 3Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 4Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: ANAs are almost always present in systemic lupus erythematosus (SLE), but they are also present in ~12-20% of the population. A positive ANA (ANA+)…
  • Abstract Number: 168 • 2017 ACR/ARHP Annual Meeting

    Identification of Novel Susceptibility Loci in a Large UK Cohort of Juvenile Idiopathic Arthritis (JIA) Cases

    Samantha Smith1, John Bowes1, Joanna Cobb2, Anne Hinks1, Sunil Sampath1, Annie Yarwood1, Lucy R Wedderburn3, Kimme L. Hyrich4 and Wendy Thomson1, 1Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, Manchester, United Kingdom, 33Arthritis Research UK Centre for Adolescent Rheumatology, UCL GOS Institute of Child Health, University College London, London, United Kingdom, 4Arthritis Research UK, Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Juvenile idiopathic arthritis (JIA) is a group of chronic arthropathies of unknown cause affecting children under 16yrs, and is the most common childhood inflammatory…
  • Abstract Number: 170 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide Association Study of Clinically-Ascertained Gout and Subtypes Identifies Multiple Susceptibility Loci Including Transporter Genes

    Hirotaka Matsuo1, Akiyoshi Nakayama2, Hirofumi Nakaoka3, Ken Yamamoto4, Masayuki Sakiyama5, Amara Shaukat6, Yu Toyoda7, Yukinori Okada8, Yoichiro Kamatani9, Masahiro Nakatochi10, Takahiro Nakamura5, Tappei Takada7, Hiroshi Nakashima5, Seiko Shimizu5, Makoto Kawaguchi5, Asahi Hishida11, Kenji Wakai11, Blanka Stiburkova12, Karel Pavelka13, Lisa K. Stamp14, Nicola Dalbeth15, Tatsuo Hosoya16, Michiaki Kubo9, Hiroshi Ooyama17, Toru Shimizu18, Kimiyoshi Ichida19, Tony R. Merriman20 and Nariyoshi Shinomiya21, 1Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, 2Dept Integrative Physiol, National Defense Med College, Tokorozawa, Japan, 3National Inst Genet, Mishima, Japan, 4Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Japan, 5National Defense Med College, Tokorozawa, Japan, 6Univ Otago, Dunedin, New Zealand, 7Univ Tokyo Hosp, Tokyo, Japan, 8Osaka University, Osaka, Japan, 9Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 10Nagoya Univ Hosp, Nagoya, Japan, 11Nagoya Univ Grad Sch Med, Nagoya, Japan, 12Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic, 13Institute of Rheumatology, Prague, Czech Republic, 14University of Otago, Christchurch, New Zealand, 15University of Auckland, Auckland, New Zealand, 16Jikei Univ Sch Med, Tokyo, Japan, 17Ryougoku East Gate Clin, Tokyo, Japan, 18Kyoto Industr Health Assoc, Kyoto, Japan, 19Tokyo Univ Pharmacy Life Sci, Tokyo, Japan, 20Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 21National Defense Med College, Saitama, Japan

    Background/Purpose: We performed a genome-wide association study (GWAS) of gout and its subtypes to identify novel gout loci including those that are subtype-specific. Methods: Putative…
  • Abstract Number: 182 • 2017 ACR/ARHP Annual Meeting

    Genetic Determinants of Fatigue in Primary Sjögren`s Syndrome – a Genome Wide Association Study

    Katrine Norheim1, Andrei Alexsson2, Juliana Imgenberg-Kreuz3, Johan Gorgas Brun4,5, Roland Jonsson6, Wan-Fai Ng7,8, Elke Theander9, Thomas Mandl10, Kathy L. Sivils11, Lars Rönnblom12, Gunnel Nordmark13 and Roald Omdal5,14, 1Clinical Immunology Department, Stavanger University Hospital, Stavanger, Norway, 2Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 3Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 4Section for Rheumatology, Haukeland University Hospital, Bergen, Bergen, Norway, 5Department of Clinical Science, University of Bergen, Bergen, Norway, 6Department of Clinical Science, Broegelmann Research Laboratory, University of Bergen, Bergen, Norway, 7Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 8Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle-Upon-Tyne, UK, Newcastle-Upon-Tyne, United Kingdom, 9Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 10Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, 11Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, 13Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, 14Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway

    Background/Purpose: Fatigue is common in primary Sjögren`s syndrome (pSS), but the mechanisms that lead to fatigue are not fully understood. We hypothesized that there is…
  • Abstract Number: 1009 • 2017 ACR/ARHP Annual Meeting

    Novel Non-Coding RNAs Associated with Rheumatoid Arthritis in Asians By Gene-Based Testing

    Aleksander Lenert1 and David W. Fardo2, 1Internal Medicine, Div. of Rheumatology, University of Kentucky, Lexington, KY, 2Biostatistics, College of Public Health, University of Kentucky, Lexington, KY

    Background/Purpose: Rheumatoid arthritis (RA) is a complex genetics disease driven by multiple genetic contributors as evidenced by association with over 100 risk SNPs by GWAS.…
  • Abstract Number: 1021 • 2017 ACR/ARHP Annual Meeting

    GWAS of Gout in Patients with Hyperuricemia Identified Many Possible New Candidate Risk Alleles

    Jing Cui1, Zhi Zhang1, Elizabeth Karlson2 and Daniel H. Solomon2, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose:  Virtually all gout patients have high levels of uric acid in the blood (hyperurincemia, HU), but approximately 80% of patients with HU will never…
  • Abstract Number: 2341 • 2017 ACR/ARHP Annual Meeting

    The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis

    Claire Deakin1, John Bowes2, Lucy Marshall1, Cerise Johnson1, Gulnara Mamyrova3, Rodolfo Curiel4, Kelly A. Rouster-Stevens5, Heinrike Schmeling6, Adam Huber7, Brian M. Feldman8, Ann M Reed9, Lauren M. Pachman10, Soumya Raychaudhuri11, Stephen Eyre12 and Lucy R Wedderburn1, 1Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, 2Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 3Rheumatology, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Department of Rheumatology, George Washington University, Washington, DC, 5Pediatric Rheumatology, Emory Children's Center, Atlanta, GA, 6Alberta Children’s Hospital/University of Calgary, Calgary, AB, Canada, 7IWK Health Centre, Halifax, NS, Canada, 8Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 9Rheumatology, Duke University, Durham, NC, 10Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 11Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 12Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease characterized by muscle weakness and rash. Clinical features of JDM are heterogeneous, and can include…
  • Abstract Number: 2343 • 2017 ACR/ARHP Annual Meeting

    A Genome-Wide Association Study Suggests the HLA Class II Region As the Major Susceptibility Locus for IgA Vasculitis

    Raquel López-Mejías1, Sara Remuzgo-Martínez1, Fernanda Genre1, Francisco David Carmona2, Santos Castañeda3, Belén Sevilla Pérez4, Norberto Ortego Centeno4, Javier Llorca5, Begoña Ubilla1, Veronica Mijares1, Trinitario Pina6, Jose A. Miranda-Filloy7, Antonio Navas Parejo8, Diego Argila9, Maximiliano Aragües10, Esteban Rubio-Romero11, Manuel Leon Luque12, Juan María Blanco Madrigal13, Eva Galindez-Agirregoikoa13, David Jayne14, Ricardo Blanco1, Javier Martin15 and Miguel Angel González-Gay16, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 2Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Departamento de Genética e Instituto de Biotecnología, University of Granada, Granada, Spain, 3Hospital Universitario La Princesa. IIS-IP. Madrid. Spain, Madrid, Spain, 4Medicine Department, Hospital Universitario San Cecilio, Granada, Spain, 5Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 6Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, 7Rheumatology Division, Hospital Lucus Augusti, Lugo, Spain, 8Nephrology Department, Hospital Universitario San Cecilio, Granada, Spain, 9Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, 10Dermatology Department, Hospital Universitario La Princesa, IIS-Princesa, MAdrid, Spain, 11Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, 12Rheumatology Department,Hospital Universitario Virgen del Rocío, Sevilla, Spain, 13Rheumatology Division, Hospital Universitario de Basurto, Bilbao, Spain, 14Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 15Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, 16Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL and School of Medicine, University of Cantabria, Santander, Spain

    Background/Purpose: Immunoglobulin-A (IgA) vasculitis, also known as Henoch-Schöenlein purpura (HSP), is the most common type of primary small-sized blood vessel leukocytoclastic vasculitis in children, although…
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