Abstracts tagged "gut microbiome"

Abstract Number: 0052 • ACR Convergence 2021
HLA-B27 Is Associated with Altered Mucosal IgA Response to Oral and Fecal Microbiota in Patients with Axial Spondyloarthritis
Tejpal Gill¹, Patrick Stauffer¹, Mark Asquith¹, Ted Laderas¹, Tammy Martin², Sean Davin¹, Claire Ramirez¹, Ingrid Lindquist¹, Justine Nguyen¹, stephen Planck¹, Carley Shaut¹, Sarah Diamond¹, James T. Rosenbaum³ and Lisa Karstens¹, ¹Oregon Health & Science University, Portland, OR, ²Departments of Ophthalmology, and Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, OR, ³Departments of Ophthalmology, Medicine, and Cell Biology, Oregon Health & Sciences University and Chair Emeritus, Legacy Devers Eye Institute, Portland, OR
Background/Purpose: Axial spondyloarthritis (AxSpA) is immune-mediated inflammatory arthritis, which affects the sacroiliac and spinal joints, and is associated with gut inflammation. Disease pathogenesis is associated…
Abstract Number: 1496 • ACR Convergence 2021
A Metagenome-wide Association Study Revealed Disease-specific Landscape of the Gut Microbiome of Systemic Lupus Erythematosus in Japanese
Yoshihiko Tomofuji¹, Yuichi Maeda², Eri Oguro-Igashira², Toshihiro Kishikawa¹, Kenichi Yamamoto¹, Kyuto Sonehara¹, Daisuke Motooka³, Yuki Matsumoto³, Hidetoshi Matsuoka⁴, Maiko Yoshimura⁴, Mayu Yagita², Takuro Nii², Shiro Ohshima⁵, Shota Nakamura³, Hidenori Inohara⁶, Kiyoshi Takeda⁷, Atsushi Kumanogoh² and Yukinori Okada¹, ¹Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan, ²Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan, ³Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan, ⁴Rheumatology and Allergology, NHO Osaka Minami Medical Center, Kawachinagano, Japan, ⁵Rheumatology and Allergology, NHO Osaka Minami Medical Center, Suita, Japan, ⁶Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ⁷Laboratory of Immune Regulation, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: Alteration of the gut microbiome has been linked to the pathogenesis of systemic lupus erythematosus (SLE). However, a comprehensive view of the gut microbiome…

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