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Abstracts tagged "Granulomatosis with Polyangiitis (GPA)"

  • Abstract Number: 1598 • ACR Convergence 2025

    Use of JAK Inhibitors in Medium- and Small-Sized Vasculitides: a Retrospective Multicenter Study

    caterina ricordi1, elena treppo2, Pavel Novikov3, Paul Russo4, Luca moroni5, Angelo Fassio6, Paolo Delvino7, hervé lobbes8, Chiara Marvisi1, Francesco Muratore1, Xavier Puéchal9, Carlo Salvarani1 and Benjamin Terrier10, 1Unit of Rheumatology, Azienda USL - IRCCS di Reggio Emilia, and University of Modena and Reggio Emilia, Reggio Emilia, Italy, 2Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, 3Sechenov University, Moscow, Russia, 4Royal Adelaide Hospital, Clinical Immunology and Allergy, Adelaide, Australia, 5IRCCS San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), Milan, Italy, 6University of Verona, Department of Medicine, Unit of Rheumatology, Verona, Italy, 7University of Milano-Bicocca, Monza, Monza and Brianza, Italy, 8Department of Internal Medicine, Hôpital Estaing, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France, 9Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( 75014 ), Ile-de-France, France, 10Cochin Hospital, Paris, France

    Background/Purpose: Medium- and small-vessel vasculitides (MVV and SVV) are a heterogeneous group of inflammatory diseases affecting the vascular wall. Current treatment strategies are based on…
  • Abstract Number: 1596 • ACR Convergence 2025

    GPA-Associated Tracheobronchial Stenosis: Immunosuppressant Use and Dilation Frequency

    Brendan Denvir1, Alexander Hillel2, Ami Shah3, Ji Soo Kim1, Philip Seo2 and Brendan Antiochos4, 1Johns Hopkins, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Johns Hopkins Rheumatology, Baltimore, MD, 4Johns Hopkins, CLARKSVILLE, MD

    Background/Purpose: Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis that affects all levels of the respiratory tract. Tracheobronchial stenosis (TBS) occurs in…
  • Abstract Number: 1595 • ACR Convergence 2025

    Subcordal Stenosis is a Glucocorticoid-Responsive Manifestation of Granulomatosis with Polyangiitis

    Brendan Denvir1, Brendan Antiochos2, Philip Seo3 and Alexander Hillel3, 1Johns Hopkins, Baltimore, MD, 2Johns Hopkins, CLARKSVILLE, MD, 3Johns Hopkins University, Baltimore, MD

    Background/Purpose: Subglottic stenosis (SGS) is a recognized manifestation of granulomatosis with polyangiitis (GPA), occurring in 8–23% of patients. A distinct variant, identified in this study,…
  • Abstract Number: 0721 • ACR Convergence 2025

    Pulmonary Manifestations of Granulomatosis with Polyangiitis and Microscopic Polyangiitis

    Mats Junek1, Sara Choi2, Stephanie Garner3, Saara Rawn4, David Cuthbertson5, Curry Koening6, Carol Langford7, Carol McAlear8, Paul Monach9, Larry Moreland10, Christian Pagnoux11, Philip Seo12, Ulrich Specks13, Kenneth Warrington13, Gerard Cox1, Nader Khalidi14 and Peter Merkel8, 1St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 2Queen's University, Kingston, ON, Canada, 3University of Calgary, Calgary, AB, Canada, 4NOSM School of Medicine, Sudbury, ON, Canada, 5University of South Florida, Tampa, 6University of Texas Dell Medical School, Austin, TX, 7Cleveland Clinic, Moreland Hills, OH, 8University of Pennsylvania, Philadelphia, PA, 9VA Boston Healthcare System, Boston, MA, 10University of Colorado, Denver, CO, 11Mount Sinai Hospital, Toronto, ON, Canada, 12Johns Hopkins University, Baltimore, MD, 13Mayo Clinic, Rochester, MN, 14McMaster University, Hamilton, ON, Canada

    Background/Purpose: There is limited knowledge of the epidemiology and complications of pulmonary manifestations in ANCA-associated vasculitis (AAV). This analysis focused describing the range of pulmonary…
  • Abstract Number: 0718 • ACR Convergence 2025

    Incidence of Venous Thromboembolism in Patients with ANCA-Associated Vasculitides – a Nationwide Registry-Based Study from Sweden

    Hanna Lindberg1, Klytaimnistra Voudouri1, Lars Lindhagen1, Maria K Svensson2, Ann Knight1 and Johanna Dahlqvist3, 1Uppsala University, Uppsala, Sweden, 2Uppsala University, Uppsala, 3Uppsala University Hospital, Uppsala, Sweden

    Background/Purpose: Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are rare yet severe autoimmune diseases. Previous studies have indicated that patients with AAV have an increased risk…
  • Abstract Number: 0713 • ACR Convergence 2025

    Differentiating Primary Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis from Secondary Forms

    Adil Vural1, Chao Zhang2, Yaseen Kinanah1, Cassandra Calabrese3 and Adam Brown4, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland Heights, OH, 3Cleveland Clinic Foundation, Cleveland Heights, OH, 4Cleveland Clinic, Shaker Heights, OH

    Background/Purpose: ANCA associated vasculitis (AAV) is a severe autoimmune disorder with substantial morbidity and mortality. Establishing the diagnosis might be challenging due to the existence…
  • Abstract Number: 0726 • ACR Convergence 2025

    Real-World Avacopan Use in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Insights from United States Claims Data on Outcomes and Adherence

    Sebastian E Sattui1, Elizabeth Ibiloye2, Niranjan Kathe3, Sam Oh4, Virginia Noxon-Wood5, Iman Mohammadi5, Laura Moore-Schiltz5 and Tingting Li6, 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Amgen Inc, Thousand Oaks, CA, 3Amgen Inc, San Diego, CA, 4Amgen Inc, South San Francisco, CA, 5Inovalon, Bowie, MD, 6Washington University School of Medicine, St. Louis

    Background/Purpose: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are the most common types of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Treatment-related toxicities, particularly from glucocorticoid…
  • Abstract Number: 1766 • ACR Convergence 2025

    Clinical Impact of Incomplete B-cell Depletion in ANCA-Associated Vasculitis Patients Receiving Maintenance Rituximab Therapy: a Retrospective Study

    caterina ricordi1, Maxime Beydon2, Johanne Liberatore3, Pascal Cohen4, bertrand Dunogue5, Camille Mettler6, Benjamin Torreau7, Luc Mouthon5, Xavier Puéchal8 and Benjamin Terrier9, 1Unit of Rheumatology, Azienda USL - IRCCS di Reggio Emilia, and University of Modena and Reggio Emilia, Reggio Emilia, Italy, 2Sorbonne University, INSERM, Institut Pierre Louis of Epidemiology and Public Health, Equipe PEPITES, Pitié Salpêtrière Hospital, Service of Public Health, Centre of Pharmacoepidemiology (Cephepi), Paris, France, 3Department of Internal Medicine, Centre Hospitalier d’Angouleme, Angouleme, France, 4Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, Paris, France, 5Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin University Hospital, Université Paris Cité, AP-HP, Paris, France, 6Department of Internal Medicine, Hôpital Bichat - Claude-Bernard, Paris, France, 7Internal Medicine and Immunology, CHU Tours, Tours, France, 8Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hospital Cochin, and Université Paris Cité, Paris ( 75014 ), Ile-de-France, France, 9Cochin Hospital, Paris, France

    Background/Purpose: Rituximab (RTX) is the standard of care for both induction and maintenance in ANCA-associated vasculitides (AAVs). While CD19 B-cell monitoring is used to evaluate…
  • Abstract Number: 1764 • ACR Convergence 2025

    Development and Validation of a Simulation Model for Induction of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Naomi Patel1, Aaron Wu2, Eli Miloslavsky3, Peter Merkel4, John Stone5, Hyon K. Choi6, Zachary Wallace3 and Emily Hyle2, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, 3Massachusetts General Hospital, Newton, MA, 4University of Pennsylvania, Philadelphia, PA, 5Massachusetts General Hospital , Harvard Medical School, Concord, MA, 6MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Evaluating the effectiveness and safety profile of treatment strategies for the induction of remission of individuals with newly diagnosed AAV is important for guiding…
  • Abstract Number: 1609 • ACR Convergence 2025

    A Multicenter Prospective Longitudinal Observational Study To Determine Safety Of Extended Treatment With Rituximab In Maintaining Remission In Patients With ANCA Associated Vasculitis (AAV) – An Interim Analysis

    Ravi Kumar U1, Anoop Chitrabhanu2, Ramya Janardana3, Avinash Jain4, Nitty Mathews5, Rutvi Dave5, Prabhu Vasantha Kumar6, ashish mathew5, john mathew5, Prasanna Samuel5, Arul Rajamurugan2, Vineeta Shobha3 and ruchika goel5, 1Christian Medical college, Vellore, India, Bengaluru, Karnataka, India, 2Madras Medical College, Chennai, India, Chennai, Tamil Nadu, India, 3St. John’s Medical College, Bengaluru , India, Bangalore, Karnataka, India, 4SMS Medical College and Hospital, Jaipur, India, JAIPUR, Rajasthan, India, 5Christian Medical college , Vellore , India, Vellore, Tamil Nadu, India, 6Christian Medical College, Vellore, Tamil Nadu, India, Vellore, Tamil Nadu, India

    Background/Purpose: Rituximab (RTX) has been shown to achieve high remission-induction and sustained maintenance rates across multiple studies and clinical trials in patients with AAV. The…
  • Abstract Number: 1607 • ACR Convergence 2025

    Antibiotic Prophylaxis during Treatment of ANCA-associated Vasculitis with Rituximab: Data from a Multicenter Cohort

    Natasha Le Blanc1, Lillian Barra2, Sasha Bernatsky3, Alison Clifford4, Mojtaba Dabaghjamanesh5, Natasha Dehghan6, Aurore Fifi-Mah7, Jean-Paul Makhzoum8, Nataliya Milman9, Medha Soowamber10, Nader Khalidi11, Christian Pagnoux10, Rosalie-Selene Meunier12, Jan Willem Cohen Tervaert4, Elaine Yacyshyn4 and Arielle Mendel13, 1McGill University, Montreal, Canada, 2Western University, London, ON, Canada, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4University of Alberta, Edmonton, AB, Canada, 5Self employed, Richmond Hill, ON, Canada, 6University of British Columbia - Vancouver, Vancouver, BC, Canada, 7University of Calgary, Calgary, AB, Canada, 8Universite de Montreal, Montreal, Canada, 9the Ottawa Hospital, Ottawa, ON, Canada, 10Mount Sinai Hospital, Toronto, ON, Canada, 11McMaster University, Hamilton, ON, Canada, 12Hopital du Sacre-Coeur-de-Montreal, Montreal, QC, Canada, 13McGill University Health Centre, Montréal, QC, Canada

    Background/Purpose: Antibiotic prophylaxis is recommended during initial treatment of ANCA-associated vasculitis (AAV). We assessed characteristics associated with prophylaxis within a Canadian multicenter AAV cohort starting…
  • Abstract Number: 1606 • ACR Convergence 2025

    One Year Real-World Effectiveness with Avacopan in Granulomatosis with Polyangiitis and Microscopic Polyangiitis in a Large Healthcare System

    Naomi Patel1, Andrew King2, Madison Negron3, Zachary Williams4, Ana Fernandes1, Nora Shepherd2, Colebrooke Johnson1, Guy Katz1, Belen Arevalo Molina1, Elizabeth Ibiloye5, Sam Oh6, Zachary Wallace7 and Sebastian H Unizony8, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, 3Harvard Extension School, Medford, MA, 4Massachusetts General Hospital, Nancy, KY, 5Amgen Inc, Thousand Oaks, CA, 6Amgen Inc, South San Francisco, CA, 7Massachusetts General Hospital, Newton, MA, 8Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Avacopan has been approved for adjunctive use in adults with severe active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) in the US. Here…
  • Abstract Number: 0774 • ACR Convergence 2024

    A Multicenter, Randomized, Controlled Trial to Evaluate the Effects of Low-dose Glucocorticoids Compared to Stopping Glucocorticoids to Maintain Remission of Granulomatosis with Polyangiitis: The TAPIR Trial

    Peter Merkel1, Christian Pagnoux2, Nader Khalidi3, Ulrich Specks4, Curry Koening5, Carol Langford6, Larry Moreland7, Paul Monach8, Jason Springer9, Shubhasree Banerjee1, Simon Carette10, Rennie Rhee1, Medha Soowamber11, Kenneth Warrington4, Renee Borchin12, Cristina Burroughs13, Carol McAlear1, David Cuthbertson13 and Jeffrey Krischer13, 1University of Pennsylvania, Philadelphia, PA, 2Mount Sinai Hospital, Toronto, ON, Canada, 3McMaster University, Hamilton, ON, Canada, 4Mayo Clinic, Rochester, MN, 5University of Texas Dell Medical School, Austin, TX, 6Cleveland Clinic, Moreland Hills, OH, 7University of Colorado, Denver, CO, 8VA Boston Healthcare System, Boston, MA, 9Vanderbilt University Medical Center, Franklin, TN, 10Mount Sinai Hosptial, Toronto, ON, Canada, 11University of Toronto, Toronto, ON, Canada, 12University of South Florida, Tampa, 13University of South Florida, Tampa, FL

    Background/Purpose: Use of low-dose glucocorticoids to maintain remission in patients with granulomatosis with polyangiitis (GPA) remains controversial.  Additionally, there is no consensus on how to…
  • Abstract Number: 0823 • ACR Convergence 2024

    A Randomized, Double-Blind, Placebo-Controlled Trial of Abatacept for the Treatment of Relapsing, Non-Severe, Granulomatosis with Polyangiitis

    Carol Langford1, Nader Khalidi2, Jason Springer3, Marcia Friedman4, Bernhard Hellmich5, Christian Pagnoux6, Natasha Dehghan7, Ora Singer8, Curry Koening9, Yih Chang Lin10, Paul Monach11, Larry Moreland12, Aurore Fifi-Mah13, Oliver Flossmann14, Lindsy Forbess15, Peter Lanyon16, Eamonn Molloy17, Ulrich Specks18, Robert Spiera19, Elaine Yacyshyn20, Carol McAlear21, Cristina Burroughs10, Rachel Jones22, Rennie Rhee21, Rula A. Hajj-Ali23, Kenneth Warrington18, David Cuthbertson10, Jeffrey Krischer10, David Jayne22 and Peter Merkel21, and the Vasculitis Clinical Research Consortium and the European Vasculitis Society, 1Cleveland Clinic, Moreland Hills, OH, 2McMaster University, Hamilton, ON, Canada, 3Vanderbilt University Medical Center, Franklin, TN, 4Oregon Health and Science University, Portland, OR, 5Medius Kliniken, Kirchheim unter Teck, Germany, 6Mount Sinai Hospital, Toronto, ON, Canada, 7University of British Columbia - Vancouver, Vancouver, BC, Canada, 8University of Michigan, Huntington Woods, MI, 9University of Texas Dell Medical School, Austin, TX, 10University of South Florida, Tampa, FL, 11VA Boston Healthcare System, Boston, MA, 12University of Colorado, Denver, CO, 13University of Calgary, Calgary, AB, Canada, 14Royal Berkshire Hospital, Reading, United Kingdom, 15Cedars-Sinai Medical Center, Los Angeles, CA, 16University of Nottingham, Nottingham, United Kingdom, 17St Vincent's University Hospital, Dublin, Ireland, 18Mayo Clinic, Rochester, MN, 19Scleroderma, Vasculitis, and Myositis Center, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 20University of Alberta, Edmonton, AB, Canada, 21University of Pennsylvania, Philadelphia, PA, 22University of Cambridge, Cambridge, United Kingdom, 23Cleveland Clinic, Cleveland, OH

    Background/Purpose: Granulomatosis with polyangiitis (GPA) is a small-vessel vasculitis associated with frequent relapses. Following encouraging results from an open-label study, a randomized, double-blind, placebo-controlled trial…
  • Abstract Number: 1592 • ACR Convergence 2024

    Overlapping Forms of Eosinophilic Granulomatosis with Polyangiitis and Granulomatosis with Polyangiitis: Presentation, Management and Outcomes

    Federica Pallotti1, Camille Mettler2, Roberto Padoan3, Francesca Regola4, Franco Franceschini5, Sergey Moiseev6, Pavel Novikov7, Mario Andrea Piga8, Gianluca Moroncini9, Silke Brix10, Abdul Hadi Kafagi11, Samuel Deshayes12, Achille Aouba12, Julien Campagne13, Paolo Delvino14, Jan Willem Cohen Tervaert15, Luisa Brussino16, Martin Michaud17, Nils Venhoff18, Federico Alberici19, Claudia Iannone20, Sophie Rosenstingl21, Marin Moutel22, Jean-Marc Galempoix23, Vincent Cottin24, Clara Jaccard25, Diane Riehl26, Paul Legendre27, Anne-Claire Billet28, Paola Parronchi29, Luca Quartuccio30, Vítor Silvestre Teixeira31, Allyson Egan32, David Jayne32, Enrico Tombetti33, Marco Caminati34, Christian Pagnoux35, Alexis Régent36, Marc Ruivard37, Loïc Guillevin38, Xavier Puéchal36 and Benjamin Terrier39, and the French Vasculities Study Group and European EGPA Study Group, 1Internal Medicine, Centre Hospitalier Universitaire de Caen, Caen, France, 2Département de Médecine Interne, Centre de Référence National pour les maladies auto-immunes systémiques rares, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France, 3Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, 4Unit of Rheumatology and Clinical Immunology, ASST Spedali Civili Brescia and University of Brescia, Brescia, Italy, 5Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 6Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia, 7Sechenov First Moscow State Medical University, Moscow, Russia, 8Postgraduate School of Allergy and Clinical Immunology, Università Politecnica delle Marche, Ancona, Italy, 9Department of Clinical and Molecular Sciences, Marche Polytechnic University & Department of Internal Medicine, Marche University Hospital, Ancona, Italy, 10Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom, 11Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester, United Kingdom, 12Service d'immunologie clinique-médecine interne, CHU de Caen Normandie, Caen, France, 13Hôpital Robert Schuman - Competence center for autoimmune diseases, Internal Medicine, Metz, France, 14University of Milano-Bicocca, Milan, Milan, Italy, 15University of Alberta, Edmonton, Canada, 16SSDDU Immunologia Clinica ed Allergologia, AO Mauriziano, Turin, Italy, 17Department of Internal Medicine, Clinique Saint-Exupery, Toulouse, France., Toulouse, France, 18Medical Center - University of Freiburg, Internal Medicine, Department of Rheumatology and Clinical Immunology, Freiburg, Germany, 19Nephrology Unit, ASST Spedali Civili di Brescia, Brescia, Italy, 20Department of Rheumatology, University of Milan, and Rheumatology Department, ASST Pini-CTO, Milan, Italy, 21Service Médecine Interne, Centre hospitalier intercommunal Compiègne Noyon, Compiègne Noyon, France, 22Department of Internal Medicine, Infectious Diseases, and Clinical Immunology, Reims University Hospital, Reims, France, 23J.M. Galempoix, MD, Department of Internal Medicine, Nord Ardennes Hospital, Charleville-Mézières, France, 24Hôpital Louis Pradel, Centre de Référence des Maladies Pulmonaires Rares, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France, Lyon, France, 25Gaston Bourret Hospital, Nouméa, New Caledonia, 26Centre hospitalier intercommunal Toulon- La Seyne Sur Mer, Toulon, France, 27Service Médecine Interne et Polyvalente, Centre Hospitaliers Le Mans, Le Mans, France, 28Department of Internal Medicine, Édouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France, 29University of Florence, Florence, Florence, Italy, 30Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, 31Department of Rheumatology, Faro Hospital, Algarve, Portugal, 32University of Cambridge, Cambridge, United Kingdom, 33Internal Medicine and Rheumatology, Department of Biomedical and Clinical Sciences, Sacco and Fatebenefratelli Hospitals, Milan, Italy, Milan, Italy, 34Department of Medicine, Asthma, Allergy and Clinical Immunology Section, University of Verona, Verona, Italy, 35Mount Sinai Hospital, Toronto, ON, Canada, 36National Referral Center For Rare Systemic Autoimmune Diseases, Paris, France, 37Internal Medicine Department, Estaing University Hospital, CHU Clermont-Ferrand, Clermonnt-Ferrand, Italy, 38National Referral Center For Rare Systemic Autoimmune Diseases, Paris, Ile-de-France, France, 39Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: ANCA-associated vasculitis (AAV) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (EGPA). Although these entities are often easily distinguished in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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