Abstracts tagged "Gout and uric acid"

Abstract Number: 2958 • 2014 ACR/ARHP Annual Meeting
Polygenic Analysis of Transport, Metabolism and Immune Related Genomic Compartments in Serum Urate and Gout
Eli A. Stahl¹, Tony R. Merriman², Amanda Dobbyn³, David B. Mount⁴, Peter Kraft⁵ and Hyon K. Choi⁶, ¹Mt Sinai School of Medicine, New York City, NY, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Renal Division, Brigham and Women's Hospital, Boston, MA, ⁵Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁶Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genome wide association studies (GWAS) have identified loci associated with complex traits, and the current challenge is to glean biological insights from these findings.…
Abstract Number: 2959 • 2014 ACR/ARHP Annual Meeting
Twenty-Eight Loci That Influence Serum Urate Levels: Analysis of Association with Gout
Tony R. Merriman¹, Marilyn E. Merriman¹, Ruth Topless¹, Sara Altaf², Grant Montgomery³, Christopher Franklin⁴, Gregory T. Jones⁵, Andre M. van Rij², Douglas HN White⁶, Lisa K. Stamp⁷, Nicola Dalbeth⁸ and Amanda Phipps-Green¹, ¹Department of Biochemistry, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³Queensland Institute of Medical Research, Brisbane, Australia, ⁴University of Auckland, Auckland, New Zealand, ⁵Surgery, University of Otago, Dunedin, New Zealand, ⁶Waikato Clinical School, Waikato Hospital, Hamilton, New Zealand, ⁷University of Otago, Christchurch, New Zealand, ⁸Department of Medicine, University of Auckland, Auckland, New Zealand
Background/Purpose: Twenty-eight genetic loci are associated with serum urate levels in Europeans. Ten are established, with a further 18 of weaker effect more recently detected.…
Abstract Number: 2961 • 2014 ACR/ARHP Annual Meeting
Conditional Analysis of 30 Serum Urate Loci Identifies 25 Additional Independent Effects
Eli Stahl¹, Hyon K. Choi², Murray Cadzow³, Tanya Flynn³, Ruth Topless⁴ and Tony R. Merriman⁴, ¹Mt Sinai School of Medicine, New York City, NY, ²Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³University of Otago, Dunedin, New Zealand, ⁴Department of Biochemistry, University of Otago, Dunedin, New Zealand
Background/Purpose: Single variants in 30 genetic loci have been associated with serum urate levels in Europeans by meta-analysis of summary statistics of 48 individual genome-wide…
Abstract Number: 1221 • 2014 ACR/ARHP Annual Meeting
Serum Uric Acid As an Independent Risk Factor on Progression of Chronic Kidney Disease in Gout Patients with Uric Acid Lowering Agent
Young Hyup Lim¹, Eun-Jung Park¹, Seulkee Lee², Hemin Jeong³, Hyungjin Kim⁴, Jinseok Kim¹, Jaejoon Lee⁵, Hoon-Suk Cha³ and Eun-Mi Koh⁶, ¹Internal Medicine, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Republic of Korea, Jeju, South Korea, ²Internal Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, Seoul, South Korea, ³Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Internal Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, Seul, South Korea, ⁵Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁶Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose Hyperuricemia is particularly common in patients with chronic kidney disease (CKD). Its role, however, as a risk factor for renal outcomes of CKD is…
Abstract Number: 1217 • 2014 ACR/ARHP Annual Meeting
The Random Urine Uric Acid to Creatinine Ratio As a Predictor of 24-Hour Urine Uric Acid Excretion in Gout Patients
Sang Tae Choi¹, Jung-Soo Song² and Eun-Hye Park², ¹Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea, ²Chung-Ang University College of Medicine, Seoul, South Korea
Background/Purpose: Gout is an inflammatory disease resulted from an increased body pool of uric acid. The measurement of 24-hour uric acid excretion is important to…
Abstract Number: 830 • 2014 ACR/ARHP Annual Meeting
Profound Hypouricemia Induced in Human Subjects By Novel Bifunctional Inhibitors of Xanthine Oxidase and URAT1
Raymond P. Warrell Jr.¹, Anna Klukovits², Keith Barnes³, Chitkala Satyanarayana⁴, Chris Cheeseman⁵ and John Piwinski¹, ¹Relburn-Metabolomics, Inc., Westfield, NJ, ²SOLVO Biotechnology, Budapest, Hungary, ³AMRI, Albany, NY, ⁴AMRI, Singapore, Singapore, ⁵University of Alberta, Alberta, AB, Canada
Background/Purpose: A prototype anticancer drug (RLBN1001) induced marked hypouricemia in studies of > 350 human subjects. Preliminary exploration suggested dual effects on uric acid (UA)…
Abstract Number: 828 • 2014 ACR/ARHP Annual Meeting
Extent of Urate Deposition in Asymptomatic Hyperuricemia and Symptomatic Gout: A Dual Energy Computed Tomography Study
Nicola Dalbeth¹, Meaghan House¹, Opetaia Aati¹, Paul Tan², Christopher Franklin², Anne Horne¹, Gregory Gamble¹, Lisa K. Stamp³, Anthony Doyle² and Fiona M. McQueen⁴, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Recent studies have reported that ultrasound features of urate crystal deposition are present in some asymptomatic individuals with hyperuricemia, suggesting that subclinical urate deposition…
Abstract Number: 2009 • 2013 ACR/ARHP Annual Meeting
Outcome Of Allopurinol Or Febuxostat Treatment In Gout Patients Naïve To Urate-Lowering Therapy
Puja Khanna¹, Hind Hatoum^2,3, Swu-Jane Lin^2,4, Aki Shiozawa⁵, Kasem Akhras⁶ and Dinesh Khanna¹, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Hind T. Hatoum and Company, Chicago, IL, ³University of Illinois at Chicago, chicago, IL, ⁴University of Illinois at Chicago, Chicago, IL, ⁵Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ⁶Global Outcomes Research, Formerly of Takeda Pharmaceuticals International, Inc, Deerfield, IL
Background/Purpose: In the US, 3.9% (8.3 million) of the population have self-reported gout, and 21.4% (43.3 million) have hyperuricemia. The 2012 ACR guidelines recommend febuxostat…
Abstract Number: 2002 • 2013 ACR/ARHP Annual Meeting
Prophylactic Duration and Serum Uric Acid Level Are Associated With Gout Flare During Urate Lowering Treatment
Hyo-Jin Choi¹, Chan Hee Lee², Sang Tae Choi³, Jung-Soo Song³, Hyoun-Ah Kim⁴, Chang-Hee Suh⁵, Hoyeon Joo⁶, Ki Chul Shin⁷ and Hanjoo Baek¹, ¹Rheumatology, Gachon University Gil Hospital, Incheon, South Korea, ²Div Rheum Dept of Intl Med, NHIC Ilsan Hospital, Goyang-si, South Korea, ³Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, ⁴Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁵Department of Rheumatology, Ajou University Hospital, Suwon, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, ⁷Rheumatology, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: To evaluate the clinical factors on gout flare during urate lowering treatment Methods: We retrospectively examined data derived from 228 patients who had been treated…
Abstract Number: 2003 • 2013 ACR/ARHP Annual Meeting
Outcome Of Gout Patients Placed On Febuxostat After Failing To Reach Serum Urate Target With Allopurinol
Hind Hatoum^1,2, Dinesh Khanna³, Aki Shiozawa⁴, Swu-Jane Lin^1,5, Kasem Akhras⁶ and Puja Khanna⁷, ¹Hind T. Hatoum and Company, Chicago, IL, ²University of Illinois at Chicago, chicago, IL, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ⁵University of Illinois at Chicago, Chicago, IL, ⁶Global Outcomes Research, Formerly of Takeda Pharmaceuticals International, Inc, Deerfield, IL, ⁷Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: The 2012 American College of Rheumatology (ACR) gout guidelines recommends allopurinol or febuxostat as first-line urate-lowering therapy (ULT). Purpose of this study was to…
Abstract Number: 2006 • 2013 ACR/ARHP Annual Meeting
Uric Acid Level Is Not An Independent Predictor Of Cardiovascular Diseases In Gout Patients With Treatment; Long-Term Follow-Up Data In Single Tertiary Center In South Korea
Seulkee Lee¹, Eun-Jung Park², Jinseok Kim³, Chan Hong Jeon⁴, Hyungjin Kim⁵, Jaejoon Lee¹, Eun-Mi Koh¹ and Hoon-Suk Cha¹, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Internal Medicine, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Republic of Korea, Jeju, South Korea, ³Internal Medicine, Jeju National University Hospital, Jeju, South Korea, ⁴Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁵Department of medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Hyperuricemia and gout are closely related conditions that are prevalent worldwide. A possible link between hyperuricemia and cardiovascular diseases (CVD) has been a debated…
Abstract Number: 1983 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Birefringent Crystals In Three Inflammation-Prone Tissues
Jane Park¹, Divya Soman², Martine P. Roudier³ and Peter A. Simkin⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Pathology, University of Washington, Seattle, WA, ⁴Div of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: When serum is hyperuricemic, so too are all interstitial fluids other than CSF and sweat. Anecdotally, urate crystals deposit as grossly visible tophi in…
Abstract Number: 1722 • 2013 ACR/ARHP Annual Meeting
Does Starting Allopurinol Prolong Acute Treated Gout?
Erica Hill¹, Jay B. Higgs², Karen Sky³, Michelle Sit⁴ and Angelique N. Collamer⁵, ¹Rheumatology, San Antonio Military Medical Center, Fort Sam Houston, TX, ²Rheumatology, San Antonio Military Medical Center, JBSA - Fort Sam Houston, TX, ³Rheumatology, US Department of Veterans Affairs, Alaska VA Healthcare System, Anchorage, AK, ⁴Subspecialty Clinic - Rheumatology, David Grant Medical Center, Travis AFB, CA, ⁵Internal Medicine, Langley AFB Hospital, Langley AFB, VA
Background/Purpose: Gout is a common cause of morbidity in the US population. Traditionally, allopurinol is not initiated during an acute episode to avoid prolonging…
Abstract Number: 1175 • 2013 ACR/ARHP Annual Meeting
ABCG2 May Influence Risk Of Gout Through Extra-Renal Metabolic Pathways: Analysis Of The Effects Of The Q141K Variant On Serum Urate Responses To a Fructose Load
Nicola Dalbeth¹, Meaghan House², Gregory Gamble², Bregina Pool¹, Anne Horne², Lauren Purvis², Angela Stewart², Marilyn E. Merriman³, Murray Cadzow⁴, Amanda Phipps-Green³ and Tony R. Merriman³, ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁴University of Otago, Dunedin, New Zealand
Background/Purpose: Genetic variation in ABCG2 is a major risk factor for hyperuricemia and gout. This gene encodes a high-capacity urate transporter expressed in the intestine,…
Abstract Number: 161 • 2012 ACR/ARHP Annual Meeting
Increased Serum Uric Acid: Consequence or Cause of Increased Cardiovascular Risk
Inger L. Meek¹, Harald E. Vonkeman² and Mart A.F.J. van de Laar³, ¹Rheumatology & Clinical Immunology, Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ²Rheumatology Center Twente, Medisch Spectrum Twente & Twente University, Enschede, Netherlands, ³Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: Reports on cardiovascular (CV) disease in hyperuricemia and gout show conflicting results. Some studies show hyperuricemia to be an independent risk factor for CV…

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