Abstracts tagged "Gout and uric acid"

Abstract Number: 1114 • 2017 ACR/ARHP Annual Meeting
Effects of Diacerein Controlled Release Tablets in Serum Uric Acid Reduction in Treating Subjects with Gout
Ying-Chou Chen Sr.¹, Shih-Chueh Chen², Chung-Tei Chou³, Carl Brown⁴, Jing-Yi Lee⁴, Wei-Shu Lu⁵ and Chang Youh Tsai⁶, ¹Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung County, Taiwan, ²Department of Endocrinology, Cheng Ching General Hospital, Taichung, Taiwan, ³Division of Allergy-Immunology-Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ⁴Medical Research, TWi Biotechnology, Inc., Taipei, Taiwan, ⁵TWi Biotechnology, Inc., Taipei, Taiwan, ⁶Division of Allergy- Immunology- Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Background/Purpose: The goal of gout treatment is to reduce serum uric acid (sUA) concentrations below the urate solubility limit. Diacerein is known as an oral…
Abstract Number: 1123 • 2017 ACR/ARHP Annual Meeting
Random Urinary Uric Acid/Creatinine Ratio Is Useful in the Estimation of 24-Hour Urine Uric Acid Excretion in Patients with Gout
Sang Tae Choi¹, Seong-Jin Moon² and Eun-Jin Kang³, ¹Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea, Republic of (South), ²Internal Medicine, Catholic Kwandong University College of Medicine, Incheon, Korea, Republic of (South), ³Internal Medicine, Busan Medical Center, Busan, Korea, Republic of (South)
Background/Purpose: Gout is a chronic inflammatory disease resulted from hyperuricemia. The measurement of 24-hour urinary uric acid excretion is frequently used to evaluate disease status…
Abstract Number: 1141 • 2017 ACR/ARHP Annual Meeting
Initial Results of a Clinical Study to Determine Whether a Tolerizing Regimen of Pegloticase Can Increase the Frequency of Subjects Having Sustained Lowering of Serum Urate
Kenneth Saag¹, Mitchell Feinman², Alan J. Kivitz³, Herbert S. B. Baraf⁴, Roy Fleischmann⁵, Arthur Kavanaugh⁶ and Peter E. Lipsky⁷, ¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²ACME Research, LLC, Orangeburg, SC, ³Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, ⁴Center for Rheumatology and Bone Research, Wheaton, MD, ⁵Southwestern Medical Center at Dallas, University of Texas, Dallas, TX, ⁶Medicine, University of California, San Diego, La Jolla, CA, ⁷AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Pegloticase is a pegylated recombinant mammalian uricase approved for treatment of persons with chronic gout refractory to standard urate lowering therapy1. Despite initial reduction…
Abstract Number: 1145 • 2017 ACR/ARHP Annual Meeting
Effectiveness of a Multidisciplinary Gout Clinic on Timely Achievement of Serum Uric Acid Goals
Kah Mun Cheong¹, Archana Vasudevan², Melonie Sriranganathan², Elena Lee¹, Serene Yeow¹ and Prista Ramskay¹, ¹Department of Pharmacy, Changi General Hospital, Singapore, Singapore, Singapore, ²Department of Medicine, Changi General Hospital, Singapore, Singapore, Singapore
Background/Purpose: The concept of a multidisciplinary gout clinic is relatively new in Singapore. Changi General Hospital launched such a clinic in 2014 to provide treat-to-target…
Abstract Number: 2058 • 2017 ACR/ARHP Annual Meeting
A Study on Febuxostat Prescribing Practices for Patients with Chronic Gout Previously Managed with Allopurinol at the Veterans Affairs Puget Sound
Percy Balderia and Elizabeth R. Wahl, Rheumatology, University of Washington School of Medicine, Seattle, WA
Background/Purpose: American College of Rheumatology (ACR) guidelines recommend use of either allopurinol or febuxostat as first-line approaches to urate lowering therapy in gout. Prior studies…
Abstract Number: 233 • 2016 ACR/ARHP Annual Meeting
New Cardiovascular Risk Factors Screening in Patients with Gout
Juan Carlos Ordoñez¹, Mariano Andres¹, Francisca Sivera², Loreto Carmona³, Paloma Vela^4,5, Eliseo Pascual^4,5 and Jose Antonio Bernal⁴, ¹RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE, Alicante, Spain, ²RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO DE ELDA, Elda, Spain, ³Instituto de Salud Musculo Esqueletica, Madrid, Spain, ⁴RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO ALICANTE, Alicante, Spain, ⁵Medicina, Universidad Miguel Hernandez, Elche, Spain
Background/Purpose: Gout is a disease triggered by the crystallization of uric acid in the joints secondary to persistent hyperuricemia, that leads to chronic inflammation. Patients…
Abstract Number: 1225 • 2016 ACR/ARHP Annual Meeting
Serum Uric Acid Testing Practices over Five Years Among Incident Gout Cases
Dena H. Jaffe¹, Arriel Benis², Natalia M. Flores³, Hagit Gabay², Robert Morlock⁴, Alyssa Klein⁵, Dana Y Teltsch⁶, Jonathan Chapnick⁷, Becca Feldman², Yair Molad⁸, Shmuel M Giveon⁹ and Maya Leventer-Roberts², ¹Health Outcomes Research, Kantar Health, Jerusalem, Israel, ²Clalit Research Institute, Clalit Health Services, Tel Aviv, Israel, ³Kantar Health, Foster City, CA, ⁴4939 Directors Place, Ardea Biosciences, Inc., San Diego, CA, ⁵AstraZeneca, Gaithersburg, MD, ⁶Evidera, Lexington, MA, ⁷Kantar Health, Horsham, PA, ⁸Rheumatology, Rabin Medical Center, Beilinson, Petah Tikva, Israel, ⁹Clalit Health Services, Tel Aviv, Israel
Background/Purpose: Gout is a chronic inflammatory disorder associated with elevated levels of serum uric acid (sUA), resulting in urate crystal deposits in soft tissues. Uncontrolled…
Abstract Number: 2274 • 2016 ACR/ARHP Annual Meeting
Evidence of Phospho-Degron Regulating Expression of Urate Secretory Transporter ABCG2
Alexis Hofherr¹, Meng Li², Michael Kottgen¹ and Owen M. Woodward², ¹Nephrology, University of Freiburg Medical Center, Freiburg, Germany, ²Physiology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: ABCG2 is a high capacity urate secretory transporter of the renal proximal tubule. The common Q141K ABCG2 mutation causes gout in humans through an…
Abstract Number: 2275 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Gout in New Zealand Polynesian People
Tanya Flynn¹, Ruth Topless¹, Murray Cadzow¹, Amanda Phipps-Green¹, Nick Burns¹, Nicola Dalbeth², Lisa K. Stamp³, Jennie Harre Hindmarsh⁴ and Tony R. Merriman⁵, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ⁵Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: The prevalence of gout in New Zealand Polynesian (Māori and Pacific) populations is approximately twice that of the New Zealand European population, with a…
Abstract Number: 2276 • 2016 ACR/ARHP Annual Meeting
Pleiotropic Effect of ABCG2 in Gout
Tony R. Merriman¹, Amanda Phipps-Green², James Boocock², Philip Riches³, Anne-Kathrin Tausche⁴, Timothy Radstake⁵, Matthijs Janssen⁶, Leo .A.B. Joosten⁷, Tim L Jansen⁸, Alexander So⁹, Jennie Harre Hindmarsh¹⁰, Lisa K. Stamp¹¹, Nicola Dalbeth¹² and Rebekah Wrigley², ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²University of Otago, Dunedin, New Zealand, ³University of Edinburgh, Edinburgh, United Kingdom, ⁴Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ⁵Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Department of Rheumatology, Rijnstate Hospital Arnhem, Arnhem, Netherlands, ⁷Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, ⁸Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁹Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, ¹⁰Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, ¹¹University of Otago, Christchurch, New Zealand, ¹²University of Auckland, Auckland, New Zealand
Background/Purpose: The ABCG2 Q141K (rs2231142) variant is an established cause of hyperuricaemia in Europeans. Although the effect size of ABCG2 rs2231142 on serum urate levels…
Abstract Number: 2277 • 2016 ACR/ARHP Annual Meeting
Exon Sequencing Reveals a Significant Burden of Non-Synonymous Variants in Both SLC22A11 (OAT4) and SLC22A12 (URAT1) in European Hyperuricemic Individuals
Tanya Flynn¹, James Boocock¹, Murray Cadzow¹, Ruth Topless¹, Amanda Phipps-Green¹, Nicola Dalbeth², Lisa K. Stamp³, David B. Mount⁴, Asim Mandal⁴, Hyon K. Choi⁵, Eli A. Stahl⁶ and Tony R. Merriman⁷, ¹University of Otago, Dunedin, New Zealand, ²University of Auckland, Auckland, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Common variants within the uric acid transporter genes SLC22A11 (OAT4) and SLC22A12 (URAT1) have been associated with hyperuricaemia and gout in multiple populations, but…
Abstract Number: 2282 • 2016 ACR/ARHP Annual Meeting
Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout ?
Tahzeeb Fatima¹, Tony R. Merriman², Lisa K. Stamp³, Nicola Dalbeth⁴, Cory Iverson⁵ and Jeffrey N. Miner⁶, ¹University of Otago, Dunedin, New Zealand, ²Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ³University of Otago, Christchurch, New Zealand, ⁴University of Auckland, Auckland, New Zealand, ⁵Ardea Biosciences, Inc., San Diego, CA, ⁶Discovery Biology, Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: Transferrin and its cell-surface receptor regulate iron uptake and ferritin sequesters free iron and acts as a store for excess iron. Ferritin has been…
Abstract Number: 3073 • 2016 ACR/ARHP Annual Meeting
Non-Additive Interaction of the Glucokinase Regulatory Protein and APOBEC1 Complementation Factor Loci with Alcohol Consumption to Influence the Risk of Gout
Humaira Rasheed¹, Lisa K. Stamp², Nicola Dalbeth³ and Tony R. Merriman⁴, ¹University of Engineering and Technology, Lahore, Pakistan, ²University of Otago, Christchurch, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand
Background/Purpose: Genome-wide association studies (GWAS) have identified loci associated with serum urate levels and the risk of gout. Some of these loci interact in a…
Abstract Number: 3188 • 2016 ACR/ARHP Annual Meeting
Association of Gout with Risk of Advanced Chronic Kidney Disease
Austin Stack¹, Betina Blak², Michelle Johnson³, Victoria Parsons³, Andrew Maguire⁴, Alyssa B Klein⁵, John Ferguson⁶ and Robert Morlock⁷, ¹Nephrology, University Hospital Limerick & Health Research Institute,University of Limerick, Limerick, Ireland, ²AstraZeneca,, Luton, United Kingdom, ³Oxon Epidemiology Ltd, London, United Kingdom, ⁴Epidemiology, Oxon Epidemiology Ltd, London, United Kingdom, ⁵AstraZeneca, Gaithersburg, MD, ⁶Graduate Entry Medical School, University of Limerick, Limerick, Ireland, ⁷Ardea Biosciences, Inc., San Diego, CA
Background/Purpose: It is speculated that gout is a risk factor for kidney disease progression. The aim of this study was to evaluate the association of…
Abstract Number: 230 • 2016 ACR/ARHP Annual Meeting
A Survey of Knowledge of Optimal Gout Management in an Academic Primary Care Setting
Stefanie Wade¹ and Micha Abeles², ¹Medicine, University of Connecticut Health Center, Farmington, CT, ²Rheumatology, Consulting Rheumatologist, Midstate Medical Center, Meriden, CT
Background/Purpose: We reviewed previous treatment approaches for gout in patients referred to a university rheumatology practice for gout management. All patients met the 2015 American…

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