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Abstracts tagged "Gout and uric acid"

  • Abstract Number: 2058 • 2017 ACR/ARHP Annual Meeting

    A Study on Febuxostat Prescribing Practices for Patients with Chronic Gout Previously Managed with Allopurinol at the Veterans Affairs Puget Sound

    Percy Balderia and Elizabeth R. Wahl, Rheumatology, University of Washington School of Medicine, Seattle, WA

    Background/Purpose: American College of Rheumatology (ACR) guidelines recommend use of either allopurinol or febuxostat as first-line approaches to urate lowering therapy in gout. Prior studies…
  • Abstract Number: 2085 • 2017 ACR/ARHP Annual Meeting

    Relationship between Gout and Asthma: A National Database Analysis

    Yiming Luo1, Jiehui Xu2, Yumeng Wen1, Alvaro Ramos-Rodriguez3, Changchuan Jiang1, Shuyang Fang1, Mustafa Kagalwalla1 and Neha Ohri4, 1Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, NY, 3Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, 4Division of Rheumatology, Department of Medicine, Mount Sinai St Luke's and Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Gout is an inflammatory disorder related to hyperuricemia and abnormal deposition of monosodium urate crystals in joints or other tissues. The relationship between serum…
  • Abstract Number: 2843 • 2017 ACR/ARHP Annual Meeting

    The Relationship between Serum Urate Concentration and Incident Gout: An Individual Participant Data Analysis

    Nicola Dalbeth1, Amanda Phipps-Green2, Christopher Frampton3, Tuhina Neogi4, William J. Taylor5 and Tony R. Merriman6, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of Otago, Christchurch, New Zealand, 4Boston University School of Medicine, Boston, MA, 5University of Otago, Wellington, New Zealand, 6Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand

    Background/Purpose: Elevated serum urate concentration (hyperuricemia) is considered to be a key risk factor for developing gout.  However, the relationship between serum urate and incident…
  • Abstract Number: 2845 • 2017 ACR/ARHP Annual Meeting

    Association between Serum Urate As a Surrogate Endpoint and Flares in People with Gout: An Ecological Study Based on a Systematic Review of Trials and Open Label Extensions

    Lisa K. Stamp1, Melanie Morillon2, William Taylor3, Nicola Dalbeth4, Marissa Lassere5, Jasvinder A. Singh6 and Robin Christensen7, 1University of Otago, Christchurch, New Zealand, 2Department of Medicine, Vejle Hospital, Denmark, Odense, Denmark, 3University of Otago, Wellington, New Zealand, 4University of Auckland, Auckland, New Zealand, 5University of New South Wales, Sydney, Australia, 6Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 7Musculoskeletal Statistics Unit, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark

    Background/Purpose: The primary efficacy measure in urate lowering therapy (ULT) trials is usually serum urate (SU). However, it is unknown whether the strength of the…
  • Abstract Number: 2897 • 2017 ACR/ARHP Annual Meeting

    A Non-Coding Genetic Variant Maximally Associated with Serum Urate Levels Is Functionally Linked to HNF4A-Dependent PDZK1 Expression

    Tony R. Merriman1, Sarada Ketharnathan2, James Boocock3, Amanda Phipps-Green2, Jisha Antony2, Megan Leaask2, Justin O'Sullivan4 and Julia Horsfield2, 1Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of California Los Angeles, Los Angeles, CA, 4University of Auckland, Auckland, New Zealand

    A non-coding genetic variant maximally associated with serum urate levels is functionally linked to HNF4A-dependent PDZK1 expressionBackground/Purpose: Genome-wide association studies have revealed several dozen genetic…
  • Abstract Number: 2276 • 2016 ACR/ARHP Annual Meeting

    Pleiotropic Effect of ABCG2 in Gout

    Tony R. Merriman1, Amanda Phipps-Green2, James Boocock2, Philip Riches3, Anne-Kathrin Tausche4, Timothy Radstake5, Matthijs Janssen6, Leo .A.B. Joosten7, Tim L Jansen8, Alexander So9, Jennie Harre Hindmarsh10, Lisa K. Stamp11, Nicola Dalbeth12 and Rebekah Wrigley2, 1Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of Edinburgh, Edinburgh, United Kingdom, 4Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, 5Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 6Department of Rheumatology, Rijnstate Hospital Arnhem, Arnhem, Netherlands, 7Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 8Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 9Rheumatology Department, Lausanne University Hospital, Switzerland, Lausanne, Switzerland, 10Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, 11University of Otago, Christchurch, New Zealand, 12University of Auckland, Auckland, New Zealand

    Background/Purpose: The ABCG2 Q141K (rs2231142) variant is an established cause of hyperuricaemia in Europeans. Although the effect size of ABCG2 rs2231142 on serum urate levels…
  • Abstract Number: 2277 • 2016 ACR/ARHP Annual Meeting

    Exon Sequencing Reveals a Significant Burden of Non-Synonymous Variants in Both SLC22A11 (OAT4) and SLC22A12 (URAT1) in European Hyperuricemic Individuals

    Tanya Flynn1, James Boocock1, Murray Cadzow1, Ruth Topless1, Amanda Phipps-Green1, Nicola Dalbeth2, Lisa K. Stamp3, David B. Mount4, Asim Mandal4, Hyon K. Choi5, Eli A. Stahl6 and Tony R. Merriman7, 1University of Otago, Dunedin, New Zealand, 2University of Auckland, Auckland, New Zealand, 3University of Otago, Christchurch, New Zealand, 4Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 6Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, 7Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand

    Background/Purpose: Common variants within the uric acid transporter genes SLC22A11 (OAT4) and SLC22A12 (URAT1) have been associated with hyperuricaemia and gout in multiple populations, but…
  • Abstract Number: 2282 • 2016 ACR/ARHP Annual Meeting

    Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout ?

    Tahzeeb Fatima1, Tony R. Merriman2, Lisa K. Stamp3, Nicola Dalbeth4, Cory Iverson5 and Jeffrey N. Miner6, 1University of Otago, Dunedin, New Zealand, 2Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 3University of Otago, Christchurch, New Zealand, 4University of Auckland, Auckland, New Zealand, 5Ardea Biosciences, Inc., San Diego, CA, 6Discovery Biology, Ardea Biosciences, Inc., San Diego, CA

    Background/Purpose: Transferrin and its cell-surface receptor regulate iron uptake and ferritin sequesters free iron and acts as a store for excess iron. Ferritin has been…
  • Abstract Number: 3073 • 2016 ACR/ARHP Annual Meeting

    Non-Additive Interaction of the Glucokinase Regulatory Protein and APOBEC1 Complementation Factor Loci with Alcohol Consumption to Influence the Risk of Gout

    Humaira Rasheed1, Lisa K. Stamp2, Nicola Dalbeth3 and Tony R. Merriman4, 1University of Engineering and Technology, Lahore, Pakistan, 2University of Otago, Christchurch, New Zealand, 3University of Auckland, Auckland, New Zealand, 4Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand

    Background/Purpose: Genome-wide association studies (GWAS) have identified loci associated with serum urate levels and the risk of gout. Some of these loci interact in a…
  • Abstract Number: 3188 • 2016 ACR/ARHP Annual Meeting

    Association of Gout with Risk of Advanced Chronic Kidney Disease

    Austin Stack1, Betina Blak2, Michelle Johnson3, Victoria Parsons3, Andrew Maguire4, Alyssa B Klein5, John Ferguson6 and Robert Morlock7, 1Nephrology, University Hospital Limerick & Health Research Institute,University of Limerick, Limerick, Ireland, 2AstraZeneca,, Luton, United Kingdom, 3Oxon Epidemiology Ltd, London, United Kingdom, 4Epidemiology, Oxon Epidemiology Ltd, London, United Kingdom, 5AstraZeneca, Gaithersburg, MD, 6Graduate Entry Medical School, University of Limerick, Limerick, Ireland, 7Ardea Biosciences, Inc., San Diego, CA

    Background/Purpose: It is speculated that gout is a risk factor for kidney disease progression. The aim of this study was to evaluate the association of…
  • Abstract Number: 230 • 2016 ACR/ARHP Annual Meeting

    A Survey of Knowledge of Optimal Gout Management in an Academic Primary Care Setting

    Stefanie Wade1 and Micha Abeles2, 1Medicine, University of Connecticut Health Center, Farmington, CT, 2Rheumatology, Consulting Rheumatologist, Midstate Medical Center, Meriden, CT

    Background/Purpose: We reviewed previous treatment approaches for gout in patients referred to a university rheumatology practice for gout management. All patients met the 2015 American…
  • Abstract Number: 233 • 2016 ACR/ARHP Annual Meeting

    New Cardiovascular Risk Factors Screening in Patients with Gout

    Juan Carlos Ordoñez1, Mariano Andres1, Francisca Sivera2, Loreto Carmona3, Paloma Vela4,5, Eliseo Pascual4,5 and Jose Antonio Bernal4, 1RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE, Alicante, Spain, 2RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO DE ELDA, Elda, Spain, 3Instituto de Salud Musculo Esqueletica, Madrid, Spain, 4RHEUMATOLOGY, HOSPITAL GENERAL UNIVERSITARIO ALICANTE, Alicante, Spain, 5Medicina, Universidad Miguel Hernandez, Elche, Spain

    Background/Purpose: Gout is a disease triggered by the crystallization of uric acid in the joints secondary to persistent hyperuricemia, that leads to chronic inflammation. Patients…
  • Abstract Number: 1225 • 2016 ACR/ARHP Annual Meeting

    Serum Uric Acid Testing Practices over Five Years Among Incident Gout Cases

    Dena H. Jaffe1, Arriel Benis2, Natalia M. Flores3, Hagit Gabay2, Robert Morlock4, Alyssa Klein5, Dana Y Teltsch6, Jonathan Chapnick7, Becca Feldman2, Yair Molad8, Shmuel M Giveon9 and Maya Leventer-Roberts2, 1Health Outcomes Research, Kantar Health, Jerusalem, Israel, 2Clalit Research Institute, Clalit Health Services, Tel Aviv, Israel, 3Kantar Health, Foster City, CA, 44939 Directors Place, Ardea Biosciences, Inc., San Diego, CA, 5AstraZeneca, Gaithersburg, MD, 6Evidera, Lexington, MA, 7Kantar Health, Horsham, PA, 8Rheumatology, Rabin Medical Center, Beilinson, Petah Tikva, Israel, 9Clalit Health Services, Tel Aviv, Israel

    Background/Purpose:  Gout is a chronic inflammatory disorder associated with elevated levels of serum uric acid (sUA), resulting in urate crystal deposits in soft tissues. Uncontrolled…
  • Abstract Number: 2274 • 2016 ACR/ARHP Annual Meeting

    Evidence of Phospho-Degron Regulating Expression of Urate Secretory Transporter ABCG2

    Alexis Hofherr1, Meng Li2, Michael Kottgen1 and Owen M. Woodward2, 1Nephrology, University of Freiburg Medical Center, Freiburg, Germany, 2Physiology, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose:  ABCG2 is a high capacity urate secretory transporter of the renal proximal tubule. The common Q141K ABCG2 mutation causes gout in humans through an…
  • Abstract Number: 2275 • 2016 ACR/ARHP Annual Meeting

    Genome-Wide Association Study of Gout in New Zealand Polynesian People

    Tanya Flynn1, Ruth Topless1, Murray Cadzow1, Amanda Phipps-Green1, Nick Burns1, Nicola Dalbeth2, Lisa K. Stamp3, Jennie Harre Hindmarsh4 and Tony R. Merriman5, 1University of Otago, Dunedin, New Zealand, 2University of Auckland, Auckland, New Zealand, 3University of Otago, Christchurch, New Zealand, 4Ngati Porou Hauora Charitable Trust, Te Puia Springs, New Zealand, 5Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand

    Background/Purpose: The prevalence of gout in New Zealand Polynesian (Māori and Pacific) populations is approximately twice that of the New Zealand European population, with a…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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