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Abstracts tagged "gout and osteoarthritis"

  • Abstract Number: 3076 • ACR/ARHP Annual Meeting 2016

    Development of a Matrix-Binding Interlukin-1 Receptor Antagonist Fusion Protein for Extended Retention in the Joint Tissues

    James Pancoast1, Richard Lee2,3 and Parth Patwari1, 1ProteoThera, Inc., Newton, MA, 2Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 3Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: A primary challenge for intra-articular delivery of protein and peptide therapies has been their short residence time in the joint tissues. The IL-1 receptor…
  • Abstract Number: 176 • ACR/ARHP Annual Meeting 2014

    Comparative Cardiovascular (CV) Risk and Outcomes Among Patients with Gout, Osteoarthritis (OA), or Both

    Svetlana Krasnokutsky1, Robert T. Keenan2, Laura Schneck1, Craig Tenner3, Helene Strauss4, Daria Crittenden5, Aaron Lehmann1 and Michael H. Pillinger1, 1NYU School of Medicine, Division of Rheumatology, New York, NY, 2Rheumatology, Duke University, Durham, NC, 3Medicine, NYU School of Medicine, New York, NY, 4NYU School of Medicine, New York, NY, 5Amgen, Thousand Oaks, CA

    Background/Purpose: Gout is associated with increased CV risk, both dependent on, and independent of traditional CV risk factors.  Recent studies suggest that OA, traditionally considered non-inflammatory,…

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