Abstracts tagged "Gout and inflammasome activation"

Abstract Number: 2968 • 2018 ACR/ARHP Annual Meeting
Role of Choline in Gouty Inflammation
Elsa Sanchez-Lopez¹, Zhenyu Zhong¹, Alex Stubelius², Shannon R Sweeney³, Ru Liu-Bryan^4,5, Juan Carlos Lacal⁶, Stefano Tiziani^3,7,8, Robert Terkeltaub^4,9, Monica Guma⁹ and Michael Karin¹, ¹Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA, ³Department of Nutritional Sciences. The University of Texas at Austin., Austin, TX, ⁴VA San Diego Healthcare System, San Diego, CA, ⁵Medicine-Rheumatology, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA, ⁶Translational Oncology. Department of Oncology, Hospital Universitario Fuenlabrada, Madrid, Spain, ⁷Department of Molecular Biosciences, College of Natural Sciences. The University of Texas at Austin., Austin, TX, ⁸Department of Pediatrics, Dell Medical School. The University of Texas at Austin., Austin, TX, ⁹Medicine, Division of Rheumatology, Allergy and Immunology. UCSD., La Jolla, CA
Background/Purpose: Gout is characterized by deposition of monosodium urate (MSU) crystals in articular joints, where they activate macrophages inducing NLRP3 inflammasome activation and bioactive IL-1β…
Abstract Number: 3166 • 2015 ACR/ARHP Annual Meeting
Epistatic Interaction of Functional Inflammasome Genetic Variants in Determining the Risk of Gout
Tony R. Merriman¹, Lisa K. Stamp², Nicola Dalbeth³, Ruth Topless⁴, Richard Day⁵, Diluk Kannangara⁵, Kenneth Williams⁵, Matthijs Janssen⁶, Tim Jansen⁷, Leo A. Joosten⁸, Timothy Radstake⁹, Philip L. Riches¹⁰, Anne-Kathrin Tausche¹¹, Frederic Lioté¹², Alex So^13,14 and Cushla McKinney⁴, ¹Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, ²Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ³Department of Medicine, University of Auckland, Auckland, New Zealand, ⁴University of Otago, Dunedin, New Zealand, ⁵University of New South Wales, Sydney, Australia, ⁶Rheumatology Dept, Ziekenhuis Rijnstate, Arnhem, Netherlands, ⁷P O Box 581, Haarlem, Netherlands, ⁸Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁹Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ¹⁰Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom, ¹¹Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany, ¹²Rheumatology Department; Inserm UMR-S606; Paris-Diderot University, hôpital Lariboisiere, Paris, France, ¹³Service De Rhumatologie, CHUV, Lausanne, Switzerland, ¹⁴Department of Rheumatology, CHUV, Lausanne, Switzerland
Background/Purpose: The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation…

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