Abstracts tagged "glycostransferases"

Abstract Number: 2745 • 2013 ACR/ARHP Annual Meeting
Reshaping Inflammatory Macrophage Development and Functions by a Monosaccharide Analogue In Rheumatoid Arthritis
Jun Li¹, Hui-Chen Hsu^2,3, PingAr Yang¹, Qi Wu¹, Bao Luo¹, Amber L Rowse⁴, David M. Spalding⁵, James A Mobley⁶, S. Louis Bridges Jr.⁷ and John D. Mountz^3,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Birmingham VA Medical Center, Birmingham, AL, ⁴Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁶University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Inflammatory macrophages (MΦs) play key roles in pathogenesis of rheumatoid arthritis (RA). Fucosylation, comprising the transfer of a fucose (6-Deoxy-L-galactose) to proteins, is regulated…

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