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Abstracts tagged "glucocorticoids"

  • Abstract Number: 0238 • ACR Convergence 2025

    Real-World Effectiveness of Mepolizumab on Gastrointestinal Involvement in Eosinophilic Granulomatosis with Polyangiitis and Hypereosinophilic Syndrome: A Multicenter Retrospective Study

    Alessia Gatti1, Francesca Regola1, Giulia Fontana2, Jacopo Mora2, Mario Andrea Piga3, Gianluca Moroncini3, Rossella Acquaviva4, Palma Carlucci4, Silvia Noviello4, Angelo Vacca4, Paolo Delvino5, Enrico Heffler6, Emanuele Nappi6, Jakub Moll7, Jan Schroeder7, Laura Losappio7, Federica Davanzo8, Roberto Padoan9, Paolo Cameli10, Edoardo Conticini11, Greta Pacini12, Alvise Berti12, Lorenzo Vrola13, Paola Tomietto13, Benedetta Fazzi14, elena treppo15, Luca Quartuccio14, Jan Willem Cohen Tervaert16, Sabrina Arnold17, Prof. Dr. med. Peter Lamprecht18, Florence Roufosse19, Ilaria Cavazzana1, Franco Franceschini20, Giacomo Emmi21 and Paola Toniati22, 1Rheumatology and Clinical Immunology Unit – ERN ReCONNET, ASST Spedali Civili of Brescia and University of Brescia, Brescia, Italy, 2Rheumatology and Clinical Immunology Unit – ERN ReCONNET, ASST Spedali Civili and University of Brescia, Brescia, Lombardia, Italy, 3Università Politecnica delle Marche and Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy, 4Section of Internal Medicine 'Guido Baccelli', Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari 'Aldo Moro', Bari, Italy, 5Rheumatology Unit, IRCCS San Gerardo dei Tintori, Monza, Italy, 6Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI) and Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Milano, Italy, 7Division of Allergy and Clinical Immunology, ASST GOM Niguarda, Milano, Italy, 8Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padova, Italy, 9Rheumatology Unit, Department of Medicine DIMED, University of Padua, Padua, Italy, 10University of Siena, Siena, Italy, 11Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Italy, Siena, Italy, 12Santa Chiara Hospital and University of Trento, Unit of Rheumatology, Trento, Italy, 13UCO Medicina Clinica, ASUGI, Cattinara Teaching Hospital, Trieste, Italy, 14Division of Rheumatology, Department of Medicine (DMED), University of Udine, Udine, Italy, 15Division of Rheumatology, Department of Medicine, University of Udine, Udine, Italy, 16University of Alberta, Edmonton, AB, Canada, 17Department of Rheumatology and Clinical Immunology, University of Lübeck, Lubeck, Germany, 18University of Lübeck, Lübeck, Germany, 19Department of Internal Medicine, Hôpital Universitaire de Bruxelles - Erasme, Université Libre de Bruxelles, Bruxelles, Belgium, 20University of Brescia, Brescia, Brescia, Italy, 21Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy, 22Rheumatology and Clinical Immunology Unit – ERN ReCONNET, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy

    Background/Purpose: Eosinophilic gastrointestinal disorders (EGIDs) are a group of disorders characterized by marked eosinophilic infiltration of the gastrointestinal (GI) tract resulting in organ dysfunction and…
  • Abstract Number: 2469 • ACR Convergence 2025

    Development of Consensus Statements on Glucocorticoid Use in Systemic Lupus Erythematosus

    Heh Shiang Sheu1, Wen Nan Huang1, Yao-Fan Fang2, Tai-Ju Lee3, Ling-Ying Lu4, Ming-Han Chen5, Der-Yuan Chen6, Fu-Chiang Yeh7, Yu-Wan Liao1, Chang-Youh Tsai8, Tsu-Yi Hsieh1, Song-Chou Hsieh9, Shue-Fen Luo2, Yu-Jih Su10, Yeong-Jian Jan Wu11 and Chun chi Lu12, 1Taichung Veterans General Hospital, Taichung, Taichung, Taiwan (Republic of China), 2Chang Gung Memorial Hospital, Taoyuan, Taoyuan, Taiwan (Republic of China), 3National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan (Republic of China), 4Kaohsiung Veterans General Hospital, Kaohsiung, Kaohsiung, Taiwan (Republic of China), 5Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 6China Medical University Hospital, Taichung, Taichung, Taiwan (Republic of China), 7Tri-Service General Hospital, Taipei, Taipei, Taiwan (Republic of China), 8Fu Jen Catholic University Hospital, New Taipei, New Taipei, Taiwan (Republic of China), 9National Taiwan Unuversity Hospital, Taipei City, Taiwan (Republic of China), 10Chang Gung Memorial Hospital, Kaohsiung, Kaohsiung, Taiwan (Republic of China), 11Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan (Republic of China), 121. Tri-Service General Hospital, Taipei, Taiwan 2. Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan, Taipei, Taiwan (Republic of China)

    Background/Purpose: Systemic glucocorticoid (GC) therapy is indispensable for treating active systemic lupus erythematosus (SLE) and lupus nephritis (LN), while contributing significantly to comorbidities and irreversible…
  • Abstract Number: 1526 • ACR Convergence 2025

    Guidance For Corticosteroid Tapering In Patients With Systemic Lupus Erythematosus: Results From An International Delphi Consensus Project

    Ed Vital1, George Bertsias2, Andrea Doria3, Sindhu Johnson4, Sarah Mackie5, Sandra Navarra6, Bas Nijmeijer7, Ayobami Olojo7, Bernardo A. Pons-Estel8, Onno Teng9 and Jinoos Yazdany10, 1University of Leeds, Leeds, England, United Kingdom, 2Rheumatology and Clinical Immunology, University Hospital of Heraklion and University of Crete Medical School and Foundation for Research and Technology-Hellas (FORTH), Infections and Immunity, Institute of Molecular Biology and Biotechnology, Heraklion, Greece, 3University of Padova, Padova, Italy, 4Division of Rheumatology, Department of Medicine, Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western and Mount Sinai Hospitals; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, 5University of Leeds, Leeds, United Kingdom, 6University of Santo Tomas, Manila, Philippines, 7AstraZeneca, Cambridge, United Kingdom, 8Grupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, 9Leiden University Medical Center, Leiderdorp, Netherlands, 10UCSF, San Francisco, CA

    Background/Purpose: Despite guidelines for SLE emphasizing the importance of tapering corticosteroids (CS), detailed recommendations on how to taper are limited. The purpose of this modified…
  • Abstract Number: 0743 • ACR Convergence 2025

    Giant Cell Arteritis Relapse After Treatment with Two Months of Prednisone and 12 Months of Tocilizumab

    David O'Dea1, Guy Katz1, Belen Arevalo Molina1, Adam Jarvie2, Mark Matza1, Ana Fernandes1, John Stone3 and Sebastian H Unizony4, 1Massachusetts General Hospital, Boston, MA, 2Emory University School of Medicine, Atlanta, GA, 3Massachusetts General Hospital , Harvard Medical School, Concord, MA, 4Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The optimal duration of tocilizumab (TCZ) treatment for giant cell arteritis (GCA) is unclear. Observational studies have shown that 50-60% of patients relapse after…
  • Abstract Number: 0045 • ACR Convergence 2025

    Genetic regulators of corticosteroid response in hepatic and adipose tissue and risk of adverse metabolic outcomes in patients with rheumatoid arthritis initiating glucocorticoids.

    Thomas Riley1, Bryant England2, Austin Wheeler2, Punyasha Roul3, Grant Cannon4, Brian Sauer5, Gary Kunkel6, Katherine Wysham7, Beth Wallace8, Andreas Reimold9, Gail Kerr10, Isaac Smith11, John Richards12, Iris Lee13, Mitchell Lazar1, Wenxiang Hu14, Michael Levin15, Scott Damrauer15, Rui Xiao16, Tate Johnson2, Ted Mikuls2, Joshua Baker1 and Michael George1, 1University of Pennsylvania, Philadelphia, PA, 2University of Nebraska Medical Center, Omaha, NE, 3UNMC, Omaha, NE, 4University of Utah and Salt Lake City VA, Salt Lake City, UT, 5Salt Lake City VA/University of Utah, Salt Lake City, UT, 6University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 7VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 8Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 9Dallas VA Medical Center, Dallas, TX, 10Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 11Duke University Hospital, Durham, NC, 12Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, 13Washington University in St Louis, Saint Louis, MO, 14Guangzhou National Laboratory, Guangzhou, China (People's Republic), 15University of Pennsylvania / Corporal Michael J. Crescenz VAMC, Philadelphia, PA, 16Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Previous studies identified single nucleotide polymorphisms (SNPs) that affect hepatocyte and adipocyte response to glucocorticoids (GCs). We aimed to determine if these candidate SNPs…
  • Abstract Number: 2273 • ACR Convergence 2025

    Impact of Upadacitinib on Glucocorticoid Reduction in Patients with Moderate-to-Severe RA Who Achieved and Maintained Clinical Remission in the 2-Year UPHOLD Study

    FRANK BUTTGEREIT1, Andrew Ostor2, Philip Conaghan3, Ana Romero4, Ivan Lagunes5, Andrew Garrison6, Tianming Gao7 and Suzan Attar8, 1Charité University Medicine Berlin, Berlin, Berlin, Germany, 2Australian National University, Canberra, Australia, 3University of Leeds, Leeds, United Kingdom, 4AbbVie, Barcelona, Spain, 5Abbvie Inc, North Chicago, IL, 6AbbVie, USA, North Chicago, IL, 7AbbVie, North Chicago, IL, 8King Abdulaziz University, Saudi Arabia, Jeddah, Saudi Arabia

    Background/Purpose: Glucocorticoids (GCs) are fast-acting drugs used to support csDMARD therapy for RA, but should be used sparingly and for short periods.1 Upadacitinib, an oral…
  • Abstract Number: 1355 • ACR Convergence 2025

    Use of parenteral compared to oral glucocorticoids in early rheumatoid arthritis is superior for chance ofbeing off steroids and escalation of therapy at 1 year

    Andreu Fernandez Codina1, Marie-France Valois2, Susan J. Bartlett3, Mishquatul Wahed4, Hugues Allard-Chamard5, Louis Bessette6, Glen Hazlewood7, Carol Hitchon8, Bindee Kuriya9, Vivian Bykerk10 and Janet Pope11, 1Western University, London, ON, Canada, 2McGill University, Pointe-Claire, QC, Canada, 3McGill University, Beaconsfield, QC, Canada, 4Western University, Windsor, ON, Canada, 5Université de Sherbrooke, Sherbrooke, Canada, 6Centre de l'Ostéoporose et de Rhumatologie de Québec, Quebec, QC, Canada, 7University of Calgary, Calgary, AB, Canada, 8University of Manitoba, Winnipeg, MB, Canada, 9University of Toronto - Toronto, Toronto, ON, Canada, 10Hospital for Special Surgery, New York, NY, 11University of Western Ontario, London, ON, Canada

    Background/Purpose: The 2023 EULAR recommendations for the management of Rheumatoid Arthritis (RA) emphasizes theimportance of limiting the dose and duration of glucocorticoids (GC) used in…
  • Abstract Number: 0739 • ACR Convergence 2025

    Tocilizumab in Giant Cell Arteritis with ischemic vs non-ischemic manifestations

    Carmen Secada-Gómez1, Javier Loricera2, Clara Moriano3, Santos Castañeda4, Javier Narváez5, Vicente Aldasoro Cáceres6, Olga Maiz7, Rafael B. Melero-González8, Paloma Vela Casasempere9, Susana Romero-Yuste10, Jose Luis Callejas11, Eugenio de Miguel12, Eva Galíndez Agirregoikoa13, Francisca Sivera14, Ivan Ferraz Amaro15, Julio Sánchez Martín16 and Ricardo Blanco1, 1Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander, Spain, Santander, Cantabria, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Immunopathology Group, Santander , Spain, Santander, Spain, 3Hospital León, LEON, Castilla y Leon, Spain, 4Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Madrid, Spain, 5Hospital Universitario de Bellvitge, Barcelona, Spain, 6Hospital Universitario de Navarra, Pamplona, Spain, 7Hospital Universitario de Donosti, Donostia, Spain, 8COMPLEXO HOSPITALARIO UNIVERSITARIO DE OURENSE, O Carballino, Spain, 9Hospital General Universitario Alicante, Alicante, Comunidad Valenciana, Spain, 10University Hospital Complex of Pontevedra, Pontevedra, Spain, 11Department of Internal Medicine, Hospital San Cecilio, Granada, Spain, 12Hospital Universitario La Paz, Madrid, Spain, 13BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 14Hospital General Universitario Elda, Elda, Spain, 15Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 16Hospital Universitario 12 de Octubre, Madrid, Spain

    Background/Purpose: Tocilizumab (TCZ) is the only approved biological drug in the treatment of giant cell arteritis (GCA). However, there are no comparative studies on the…
  • Abstract Number: 0203 • ACR Convergence 2024

    Agreement of Administrative Pharmacy Dispensing with Patient-Reported Use of Oral Glucocorticoids in a Rheumatoid Arthritis Cohort

    Beth Wallace1, Bryant England2, Joshua Baker3, Sauer brian4, Jorge Rojas5, Punyasha Roul6, Michael George7, Katherine Wysham8, Hannah Brubeck9, Isaac Smith10, Liron Caplan11, Paul Monach12, Gail Kerr13, Gary Kunkel14, Tawnie Braaten15, Ted Mikuls2 and grant Cannon16, 1Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, 2University of Nebraska Medical Center, Omaha, NE, 3Department of Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5Seattle VA, Mexico, Mexico, 6UNMC, Omaha, NE, 7University of Pennsylvania, Philadelphia, PA, 8VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 9VA Puget Sound Health Care System, Seattle, WA, 10Duke Department of Medicine; VA Durham Healthcare System, Durham, NC, 11Univ of Colorado School of Medicine/Rocky Mtn Regional Veterans Affairs Medical Center, Aurora, CO, 12VA Boston Healthcare System, Boston, MA, 13Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 14University of Utah/VA Salt Lake City Health Care, Salt Lake City, UT, 15UNIVERSITY OF UTAH, Salt Lake City, UT, 16University of Utah and Salt Lake City VA, Salt Lake City, UT

    Background/Purpose: Administrative claims are often used to evaluate oral glucocorticoid (GC) use in RA for clinical and research purposes, despite limited evidence to support their…
  • Abstract Number: 1483 • ACR Convergence 2024

    Real World Data on Infections from the Indian SLE Inception Cohort for Research (INSPIRE): Spectrum and Risk Factors

    SAUMYA TRIPATHY1, DEBASISH PANDIT2, Sarit Pattanaik3, Liza Rajasekhar4, VINEETA SHOBHA5, Chengappa Kavadichanda6, Ashish J Mathew7, Parasar Ghosh8, Ranjan Gupta9, Manish Rathi10, AVINASH JAIN11, MANOJ PARIDA12, Bidyut Das13 and Amita Aggarwal14, 1SCB Medical College, Cuttack, Odisha, India, Cuttack, Orissa, India, 2SJM MCH, Puri, Puri, Orissa, India, 3SCB Medical College and Hospital, Cuttack, Odisha, Cuttack, Orissa, India, 4Nizam's Institute of Medical Sciences, Madhapur, Andhra Pradesh, India, 5ST JOHN'S MEDICAL COLLEGE, BENGALURU, Karnataka, India, 6Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India, 7Christian Medical College, Vellore, Tamil Nadu, India, 8Govt of West Bengal, Kolkata, India, Kolkata, West Bengal, India, 9All India Institute of Medical Sciences, New Delhi, Delhi, India, 10Postgraduate Institute of Medical Education & Research, Chandigarh, Chandigarh, India, 11SMS MCH, JAIPUR, JAIPUR, Rajasthan, India, 12SCB MEDICAL COLLEGE, CUTTACK, Cuttack, Orissa, India, 13SCB Medical College, Cuttack, Orissa, India, 14Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Infections in SLE are a major cause of morbidity and mortality. The susceptibility to infections in SLE is multifactorial. Immune dysregulation, immunosuppressive drug use and…
  • Abstract Number: 2032 • ACR Convergence 2024

    A Systematic Review of Treatment Strategies in VEXAS Syndrome

    Aviraag Vijaya Prakash1, Jose Garcia2, Anurag Goel3, Vinit Gilvaz4 and Raveena Midha5, 1Saint Vincent Hospital, Department of Internal Medicine, Worcester, MA, 2Brown University, East Greenwich, RI, 3The Warren Alpert Medical School of Brown University, Providence, RI, 4The Warren Alpert Medical School of Brown University, East Providence, RI, 5Kent Hospital/Brown University, Warwick, RI

    Background/Purpose: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, first described in 2020, is an autoinflammatory condition characterized by somatic mutations in the UBA1 gene.…
  • Abstract Number: 2501 • ACR Convergence 2024

    Long-term Remission off Therapy (LTROT) Is Possible in Non-infectious Aortitis with DMARDs with Low Risk of Secondary Adrenal Insufficiency

    Rohit Vijjhalwar1, Vithushanan Ketheeswaranathan2, Aman More2, Rajinder Andev3 and Shirish Dubey4, 1University of Oxford, Staines, United Kingdom, 2Medical Sciences Division, University of Oxford, Oxford, United Kingdom, 3Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 4Oxford University Hospitals NHS FT, Oxford, United Kingdom

    Background/Purpose: Non-infectious Aortitis is a rare form of large vessel vasculitis which has a high risk of complications1. There is limited data on the management…
  • Abstract Number: 0295 • ACR Convergence 2024

    Mycophenolate Mofetil in the Treatment of Patients with Isolated Cardiac Sarcoidosis

    Namitha Nair1, Leen Al Saleh2, Haya Haddad3, Maria Jaimes Reyes4, Vishakha Chetram5, Farooq Sheikh6, FLORINA CONSTANTINESCU7 and Anjani Pillarisetty8, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2Watson Clinic, Lakeland, FL, 3Medstar Washington Hospital Center, Silver Spring, MD, 4Medstar Washington Hospital Center/Georgetown University, Washington, DC, 5Inova Schar Heart and Vascular, Falls Chirch, VA, 6MedStar Heart and Vascular Institute, Georgetown University School of Medicine, Washington, DC, 7MedStar Washington Hospital Center, Washington, DC, 8Carson Tahoe Medical Group, Reno, NV

    Background/Purpose: Cardiac involvement is seen in approximately a fourth of patients with sarcoidosis, a non-necrotizing granulomatous systemic disease. Among these patients, 25% may have isolated cardiac…
  • Abstract Number: 1495 • ACR Convergence 2024

    Real-World Reduction in Disease Flares and Oral Corticosteroid Use with Anifrolumab Therapy in Systemic Lupus Erythematosus: A Claims-Based Study

    Mawuena Binka1, Rana Muhammad Qasim Khan2, Joseph Tkacz3, Donna McMorrow3, Laurence Gozalo3 and Gail Kerr4, 1BioPharmaceuticals Medical, AstraZeneca, Wilmington, DE, 2BioPharmaceuticals Medical, AstraZeneca, Wilmington, 3Inovalon, Bowie, MD, 4Veterans Affairs Medical Center, Georgetown and Howard University Hospitals, Washington, DC

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease characterized by frequent episodes of disease activity (flares) of varying severity.1 SLE flares are…
  • Abstract Number: 2139 • ACR Convergence 2024

    Generation of a Human 3D Bone Model to Mimic Glucocorticoid- induced Osteoporosis In Vitro

    Johannes Plank1, Moritz Pfeiffenberger1, Alexandra Damerau1, Timo Gaber1 and FRANK HARTMUT DR. BUTTGEREIT2, 1Charité-Universitätsmedizin Berlin, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany, 2Charité University Medicine Berlin, Berlin, Germany

    Background/Purpose: Osteoporosis is a bone disease characterized by low bone mass and changes in bone architecture, often leading to pain, fractures and reduced mobility in…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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