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Abstracts tagged "glucocorticoids"

  • Abstract Number: 1118 • 2014 ACR/ARHP Annual Meeting

    Olecranon Bursitis Is Often Hemorrhagic and Responds to Steroid Injections

    Kyriakos A. Kirou1 and Naveed Chaudhry2, 1Hospital for Special Surgery, New York, NY, 2Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose . Olecranon bursitis is a common presentation to an outpatient rheumatology practice. The differential diagnosis includes crystalline bursitis (gout and pseudogout), inflammatory bursitis due…
  • Abstract Number: 919 • 2014 ACR/ARHP Annual Meeting

    Glucocorticoid Exposure and Fracture Risk in a Large Cohort of Commercially-Insured Rheumatoid Arthritis Patients Under Age 65

    Akhila Balasubramanian1, Sally Wade2, Robert A Adler3, Celia Fang (Lin)4, Michael Maricic5, Cynthia O'Malley1, Kenneth G. Saag6 and Jeffrey R. Curtis7, 1Center for Observational Research, Amgen, Inc., Thousand Oaks, CA, 2Wade Outcomes Research and Consulting, Salt Lake City, UT, 3Internal Medicine, Hunter Holmes McGuire VA Medical Center, Richmond, VA, 4Amgen, Thousand Oaks, CA, 5Catalina Pointe Rheumatology, Tucson, AZ, 6Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, 7The University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose Systemic glucocorticoid use can increase fracture risk, although dose-specific effects are not well understood, especially in younger adults.  Underlying diseases (e.g., rheumatoid arthritis [RA])…
  • Abstract Number: 824 • 2014 ACR/ARHP Annual Meeting

    Impact of Oral Glucocorticoid Therapy on Mortality in Patients with Rheumatoid Arthritis and Diabetic Mellitus

    Mohammad Movahedi and William G Dixon, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose Glucocorticoid (GC) therapy is known to increase the risk of new-onset type 2 diabetes mellitus (DM). Furthermore, GC therapy increases blood glucose in diabetic…
  • Abstract Number: 29 • 2014 ACR/ARHP Annual Meeting

    Impaired Bone Healing in Patients Suffering from Rheumatoid Arthritis – Anti-Inflammatory Therapy As Confounder

    Annemarie Lang1, Sarah Fuegener2, Paula Hoff2, Anastasia Rakow3, Manuela Jakstadt4, Timo Gaber4, Gerd Burmester2, Carsten Perka3 and Frank Buttgereit5, 1Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 3Center for Musculoskeletal Surgery, Orthopedic Department, Charité University Medicine, Berlin, Germany, 4Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany, 5Charité University Hospital, Berlin, Germany

    Background/Purpose Anti-inflammatory treatment of rheumatoid arthritis (RA) with glucocorticoids (GC) and/or non-steroidal anti-inflammatory drugs (NSAIDs) is supposed to negatively influence bone metabolism and healing. It…
  • Abstract Number: L13 • 2014 ACR/ARHP Annual Meeting

    Monthly Ibandronate Reduces Bone Loss in Osteopenic Women with Rheumatoid Arthritis Receiving Long-Term Glucocorticoids: A 48-Week Double-Blinded Randomized Placebo-Controlled Investigator-Initiated Trial

    Kichul Shin1, Sung-Hwan Park2, Won Park3, Han Joo Baek4, Yun Jong Lee5, Seong-Wook Kang6, Jung-Yoon Choe7, Wan-Hee Yoo8, Yong-Beom Park9, Jung-Soo Song10, Bin Yoo11, Dae-Hyun Yoo12 and Yeong Wook Song13, 1Rheumatology, SMG-SNU Boramae Medical Center, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 3Medicine/Rheumatology, Inha University Hospital, Incheon, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 6Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, 7Division of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, South Korea, 8Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 9Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 10Rheumatology, Chung-Ang Univ Hospital, Seoul, South Korea, 11Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 12Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 13Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, South Korea

    Background/Purpose: Long-term use of glucocorticoids (GC) is problematic for patients with increased risk for vertebral fractures, especially those with rheumatoid arthritis (RA). Thus, prevention of…
  • Abstract Number: 2913 • 2014 ACR/ARHP Annual Meeting

    Does Corticosteroid Therapy at Disease Onset Influence Disease Progression of RA? Results from the Swiss Prospective Observational Cohort

    Ruediger Mueller1, Nazim Reshiti2, Toni Kaegi3, Axel Finckh4, Hendrik Schulze-Koops5, Michael H. Schiff6 and Johannes von Kempis7, 1Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 2Division of Rheumatology, St. Gallen, Switzerland, 3Division of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Switzerland, 4Rheumatology, Geneva University Hospital, Geneva, Switzerland, 5Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, 6School of Medicine, University of Colorado, Denver, CO, 7Rheumatology, St. Gallen Hospital, CH- 9007 St.Gallen, Switzerland

    Background/Purpose Anti-inflammatory and disease-modifying properties of glucocorticoids (GCs) have been demonstrated in patients with rheumatoid arthritis (RA). Better outcomes in trials by combinations of synthetic…
  • Abstract Number: 2375 • 2014 ACR/ARHP Annual Meeting

    Should Physician Reduce patients’ Glucocorticoids to Offset the Risk of Serious Infection Event Among RA Patients Who Switched from Non-Biologic Dmards and Glucocorticoid to Biologics?

    Huifeng Yun1, Lang Chen2, George W. Reed3, Joel M. Kremer4, Jeffrey D. Greenberg5 and Jeffrey R. Curtis6, 1Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, 2Medicine, University of Alabama at Birmingham, Birmingham, AL, 3Corrona, LLC., Southborough, MA, 4Medicine, Albany Medical College and the Center for Rheumatology, Albany, NY, 5Rheumatology, New York University School of Medicine, New York, NY, 6University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Glucocorticoids (GCs) and biologic disease-modifying antirheumatic drugs (DMARDs) have previously been associated with serious infection events (SIEs) among rheumatoid arthritis (RA) patients. For patients…
  • Abstract Number: 2225 • 2014 ACR/ARHP Annual Meeting

    Does Previous Corticosteroid Treatment Affect the Inflammatory Infiltrate Found in Polymyositis Muscle Biopsies?

    Mayara Mendes Pinhata1, Juliana Jesus do Nascimento1, Suely Kazue Nagahashi Marie2 and Samuel Katsuyuki Shinjo1, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: We conducted this study because there have been no studies evaluating the effect of the use of corticosteroids (CE) on the presence of inflammatory…
  • Abstract Number: 2336 • 2013 ACR/ARHP Annual Meeting

    Phase 2 Evaluation Of PF-04171327, a Dissociated Agonist Of The Glucocorticoid Receptor, For The Treatment Of Rheumatoid Arthritis In Patients With An Inadequate Response To Methotrexate

    Thomas Stock1, Dona Fleishaker2, Xin Wang2, Arnab Mukherjee2 and Charles Mebus2, 1Pfizer Inc., Collegeville, PA, 2Pfizer Inc., Groton, CT

    Background/Purpose: PF-04171327, a pro drug of PF-00251802, is under investigation as a potential dissociated agonist of the glucocorticoid receptor (DAGR). PF-00251802 is a selective high-affinity…
  • Abstract Number: 2081 • 2013 ACR/ARHP Annual Meeting

    Role Of Muscle Persistent CD28null T Cells In Glucocorticoid Therapy Resistance In Myositis Patients

    Jayesh Pandya1, Ingela M. Loell2, Mohammad Shahadat Hossain2, Mei Zong2, Sukanya Raghavan2, Ingrid E. Lundberg3 and Vivianne Malmström2, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, 3Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Polymyositis (PM) and dermatomyositis (DM) are characterized by infiltration of T cells and macrophages in skeletal muscle tissue. Conventional immunosuppressive treatment has limited effects…
  • Abstract Number: 1693 • 2013 ACR/ARHP Annual Meeting

    Initial Triple DMARD Therapy Is More Efficient Than Methotrexate Monotherapy In Recent Onset Rheumatoid Arthritis; 1-Year Data Of a Randomized Clinical Trial (tREACH)

    P.H.P. de Jong1, J.M.W. Hazes2, K.H. Han3, A.M. Huisman4, D. van Zeben5, P.A. van der Lubbe6, A.H. Gerards6, B. van Schaeybroeck7, P.B. de Sonnaville8, M.V. Krugten9, J.J. Luime2 and A.E.A.M. Weel3, 1Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 2Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 3Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 4Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 5Department of Rheumatology, Sint Franciscus Gasthuis, Rotterdam, Netherlands, 6Department of Rheumatology, Vlietland Hospital, Schiedam, Netherlands, 7Rheumatology, Albert Schweitzer Hospital, Dordrecht, Netherlands, 8Department of Rheumatology, Admiraal de Ruyter hospital, Goes, Netherlands, 9Department of Rheumatology, Admiraal de Ruyter Hospital, Vlissingen, Netherlands

    Background/Purpose: Recommended treatment for DMARD naïve patients is methotrexate (MTX) with or without glucocorticoids (GCs). Triple DMARD therapy however is not recommended, because well proven…
  • Abstract Number: 1663 • 2013 ACR/ARHP Annual Meeting

    Obese Polymyalgia Rheumatica Patients Experience More Pain and Disability and Need Higher Doses Of Glucocorticoids

    Marco A. Cimmino1, Bhaskar Dasgupta2, Cynthia S. Crowson3, Michael Schirmer4, Christian Dejaco5, Carlo Salvarani6 and Eric L. Matteson7, 1Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, 2Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom, 3Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 4Internal medicine, Innsbruck Medical University, Innsbruck, Austria, 5Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria, 6Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 7Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Obesity is not only a risk factor for osteoarthritis but also for rheumatoid arthritis (RA). In obese RA patients, disease incidence is higher and…
  • Abstract Number: 1479 • 2013 ACR/ARHP Annual Meeting

    Relationship Between physicians’ Decision To Use Concomitant Glucocorticoid and Remission During Treatment With Tocilizumab In Patients With Background Of Limited Dose Of MTX

    Toshihisa Kojima1, Nobunori Takahashi2, Koji Funahashi3, Shuji Asai1, Masahiro Hanabayashi1, Shinya Hirabara4, Nobuyuki Asai5 and Naoki Ishiguro2, 1Orthopedic Surgery and Rheumatology, Nagoya University Hospital, Nagoya, Japan, 2Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 3Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 4Rheumatology, Toyohashi Municipal Hospital, Toyohashi, Japan, 5Nagoya Univeristy Hospital, Nagoya, Japan

    Background/Purpose: Now, predictive factors at baseline for the good outcome of treatment with biologics are very important not to waste time to treatment goal “remission”.…
  • Abstract Number: 1420 • 2013 ACR/ARHP Annual Meeting

    Induction Therapy With Adalimumab On Top Of An Aggressive Treat-To-Target Strategy With Methotrexate and Intraarticular Corticosteroid Reduces Radiographic Erosive Progression In Early Rheumatoid Arthritis, Even After Withdrawal Of Adalimumab. Results Of a 2-Year Trial (OPERA)

    Kim Hørslev-Petersen1, Lykke Midtbøll Ørnbjerg2, Merete Lund Hetland3, Peter Junker4, Jan Pødenphant5, Torkell Ellingsen6, Palle Ahlqvist7, Hanne M. Lindegaard8, Asta Linauskas9, Annette Schlemmer10, Mette Y. Dam11, Ib Hansen12, Tine Lottenburger7, Anette Jørgensen13, Sophine B. Krintel14, Johnny Raun15, Christian G. Ammitzbøll11, Julia Johansen14, Mikkel Østergaard16 and Kristian Stengaard-Pedersen11, 1Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, 2Copenhagen Center for Arthritis Reasearch, Center for Rheumatology and Spine diseases, Glostrup Hospital, Copenhagen, Denmark, 3DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark, 4University of Southern Denmark, Odense, Denmark, 5Copenhagen University at Gentofte, Hellerup, Denmark, 6Silkeborg Regional Hospital, Silkeborg, Denmark, 7University of Southern Denmark, Vejle, Denmark, 8Department of Rheumatology, Odense University Hospital, Odense, Denmark, 9Vendsyssel Hospital, Hjørring, Denmark, 10Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 11Arhus University Hospital, Aarhus, Denmark, 12Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 13Rheumatology, Arhus University Hospital, Aarhus, Denmark, 14Copenhagen University and Glostrup Hospital, Copenhagen, Denmark, 15University of Southern Denmark, Graasten, Denmark, 16Copenhagen University Hospital Glostrup, Copenhagen, Denmark

    Background/Purpose: In a randomized double-blind, placebo-controlled 2-year investigator-initiated trial of patients with early rheumatoid arthritis¹ (RA) we aimed to investigate if additional adalimumab (ADA) for…
  • Abstract Number: 1218 • 2013 ACR/ARHP Annual Meeting

    Incidence Of and Risk Factors For Clinical Fractures In Patients With Systemic Lupus Erythematosus and Matched Controls: A Population-Based Study In The United Kingdom

    Irene Bultink1, Nicholas Harvey2, Arief Lalmohamed3,4, Cyrus Cooper5, Willem Lems6, Tjeerd Van Staa2,3,7 and Frank de Vries3,4,8,9, 1Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2University of Southampton, MRC Lifecourse Epidemiology Unit, Southampton, United Kingdom, 3Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, Netherlands, 4Clinical Pharmacy, University Medical Center Utrecht, Utrecht, Netherlands, 5NDORMS; MRC Lifecourse Epidemiology Unit, University of Oxford; Southampton General Hospital, Southampton, United Kingdom, 6Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 7Medicine and Helathcare Products Regulatory Agency, Clinical Practice Research Datalink, London, United Kingdom, 8Care and Public Health Research Institute, Maastricht, Netherlands, 9Clinical Pharmacy and Toxicology, Maastricht University Medical Centre, Maastricht, Netherlands

    Background/Purpose: Systemic lupus erythematosus (SLE) has been associated with an increased risk of low bone mineral density and fractures. However, data on absolute fracture risk…
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