ACR Meeting Abstracts

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Abstracts tagged "glucocorticoids and osteoporosis"

  • Abstract Number: 1818 • 2018 ACR/ARHP Annual Meeting

    Greater BMD Gains with Denosumab Vs Risedronate in Glucocorticoid-Treated Subjects: Results from the Final 24-Month Analysis of a Randomized, Double-Blind, Double-Dummy Study

    Kenneth Saag1, Nicola Pannacciulli2, Piet Geusens3, Jonathan D. Adachi4, Osvaldo D. Messina5, Jorge Morales-Torres6, Ronald Emkey7, Peter W. Butler2, Xiang Yin2 and Willem F. Lems8, 1University of Alabama at Birmingham, Birmingham, AL, 2Amgen Inc., Thousand Oaks, CA, 3Maastricht University, Maastricht, Netherlands, 4McMaster University, Hamilton, ON, Canada, 5Cosme Argerich Hospital, Buenos Aries, Argentina, 6Hospital Aranda de la Parra, Leon, Mexico, 7Emkey Arthritis & Osteoporosis Clinic, Wyomissing, PA, 8VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Denosumab 60 mg subcutaneously every 6 months (Q6M) increased spine and hip BMD significantly more than risedronate 5 mg orally once daily (QD) at…
  • Abstract Number: 2299 • 2018 ACR/ARHP Annual Meeting

    Subgroup Analysis of the Effect of Denosumab Compared with Risedronate on Percentage Change in Lumbar Spine Bone Mineral Density at 24 Months in Glucocorticoid-Treated Individuals

    Kenneth Saag1, Nicola Pannacciulli2, Piet Geusens3, Jonathan D. Adachi4, Eric Lespessailles5, Jorge Malouf6, Bente Langdahl7, Peter W. Butler2, Xiang Yin2 and Willem F. Lems8, 1University of Alabama, Birmingham, AL, 2Amgen Inc., Thousand Oaks, CA, 3Maastricht University, Maastricht, Netherlands, 4McMaster University, Hamilton, ON, Canada, 5University Hospital Orleans, Orleans, France, 6Hospital San Pablo, Barcelona, Spain, 7Aarhus University, Aarhus, Denmark, 8VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: We previously demonstrated that denosumab increased lumbar spine and total hip bone mineral density (BMD) significantly more than risedronate at 12 and 24 months…
  • Abstract Number: 2313 • 2018 ACR/ARHP Annual Meeting

    The Efficacy of Denosumab for Prevention of Osteoporotic Fractures in Patients with Connective Tissue Diseases Receiving Very High Doses of Glucocorticoid

    Keiichiro Kadoba, Keisuke Nishimura, Hiroki Mukoyama, Rintaro Saito, Daisuke Waki and Toshihiko Yokota, Department of Endocrinoligy and Rheumatology, Kurashiki Central Hospital, Kurashiki, Japan

    Background/Purpose: Osteoporosis is a common complication of glucocorticoid therapy, contributing to significant morbidity especially in patients receiving very high doses of glucocorticoid (GC). There have…
  • Abstract Number: 2330 • 2018 ACR/ARHP Annual Meeting

    Vitamin D and Bisphosphonate Therapy in SLE Patients Who Receive Glucocorticoids: Are We Offering the Best Care?

    Smarika Sapkota1, Sara Baig2, Toy Hess3, Ann Marie O'Connell4, Jeremiah Menk3, Parastoo Fazeli5 and Anna K. Shmagel6, 1Division of General Internal Medicine, University of Minnesota, Minneapolis, MN, 2Department of Internal Medicine, University of Minnesota, Minneapolis, MN, 3University of Minnesota, Minneapolis, MN, 4University of Minnesota, Minnepolis, MN, 5Rheumatology, University of Minnesota, Minneapolis, MN, 6Rheumatic & Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Glucocorticoids(GC) are frequently used for the treatment of systemic lupus erythematosus (SLE), and glucocorticoid induced osteoporosis (GIOP) is a well-known complication of long term…
  • Abstract Number: 331 • 2017 ACR/ARHP Annual Meeting

    Case Series: Comparison of Repository Corticotropin Injection (H.P. Acthar Gel) Versus Glucocorticoids on Bone Density in SLE Patients

    Anny T. Wu1 and Joshua June2, 1Rheumatology, Franciscan Alliance, Munster, IN, 23394 E Jolly Rd Ste C, Great Lakes Center of Rheumatology, Lansing, MI

    Background/Purpose: Repository Corticotropin Injection (RCI) is an adrenocorticotropin hormone in 16% gelatin with a prolonged release after intramuscular (IM) or subcutaneous injection. Adverse effects of…
  • Abstract Number: 1888 • 2017 ACR/ARHP Annual Meeting

    Effect of Denosumab Compared with Risedronate on Percentage Change in Lumbar Spine Bone Mineral Density at 12 Months in Subgroups of Glucocorticoid-Treated Individuals

    Kenneth Saag1, N Pannacciulli2, P Geusens3, J Adachi4, Eric Lespessailles5, J Malouf6, O Messina7, AT Wang2, Rachel B. Wagman2 and WF Lems8, 1University of Alabama, Birmingham, AL, 2Amgen Inc., Thousand Oaks, CA, 3Maastricht University, Maastricht, Netherlands, 4McMaster University, Hamilton, ON, Canada, 5University Hospital Orleans, Orleans, France, 6Hospital San Pablo, Barcelona, Spain, 7Cosme Argerich Hospital, Buenos Aries, Argentina, 8VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Glucocorticoid (GC)-induced osteoporosis (GIOP) remains the most common secondary cause of osteoporosis. We previously demonstrated that denosumab (DMAb) significantly increased lumbar spine (LS) BMD…
  • Abstract Number: 2L • 2016 ACR/ARHP Annual Meeting

    Effect of Denosumab Compared with Risedronate in Glucocorticoid-Treated Individuals: Results from the 12-Month Primary Analysis of a Randomized, Double-Blind, Active-Controlled Study

    K Saag1, RB Wagman2, P Geusens3, JD Adachi4, O Messina5, R Emkey6, R Chapurlat7, NS Daizadeh2, N Pannacciulli2 and WF Lems8, 1University of Alabama at Birmingham, Birmingham, AL, USA, Birmingham, AL, 2Amgen Inc., Thousand Oaks, CA, 3Maastricht University, Maastricht, Netherlands, 4McMaster University, Hamilton, ON, Canada, 5Cosme Argerich Hospital, Buenos Aires, Argentina, 6Emkey Arthritis & Osteoporosis Clinic, Wyomissing, PA, 7Hôpital Edouard Herriot, Lyon, France, 8VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Glucocorticoid (GC)-induced osteoporosis (GIOP) remains the most common secondary cause of osteoporosis. Despite approved therapies, many subjects do not receive GIOP prevention or treatment.…
  • Abstract Number: 364 • 2015 ACR/ARHP Annual Meeting

    Very High Frequency of Fragility Fractures Associated with High-Dose Glucocorticoids in Postmenopausal Women: A Retrospective Study

    Goichi Kageyama1, Takaichi Okano1, Yuzuru Yamamoto1, Keisuke Nishimura1, Daisuke Sugiyama2, Jun Saegusa1, Goh Tsuji3, Shunichi Kumagai4 and Akio Morinobu1, 1Department of Rheumatology, Kobe University Hospital, Kobe, Japan, 2Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan, 3The Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, 4The Center of Rheumatic Diseases, Shinko Hospital, Kobe, Japan

    Background/Purpose: To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease.Methods: A retrospective study of patients who were treated with high-dose…
  • Abstract Number: 368 • 2015 ACR/ARHP Annual Meeting

    The Effects of Monitoring on a Quality Indicator for Glucocorticoid–Induced Osteoporosis and Trends of the Drug Variation in a Japanese Hospital

    Masei Suda1, Masato Okada1, Yasuhiro Suyama2, Mitsumasa Kishimoto1 and Tokutaro Tsuda1, 1Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 2Rheumatology, JR Tokyo General Hospital, Tokyo, Japan

    Background/Purpose: Glucocorticoid-induced osteoporosis (GIOP) is one of the most clinically significant side effects of glucocorticoid use, and the prevention of GIOP has become more important…
  • Abstract Number: 233 • 2014 ACR/ARHP Annual Meeting

    Significance of Serum Marker Levels of Wnt/ß-Catenin Signaling Pathway in Patients with Systemic Autoimmune Diseases Under Glucocorticoid Therapy; A Prospective Study

    Mai Kawazoe, Kotaro Shikano, Kaichi Kaneko, Shotaro Masuoka, Hiroshi Sato, Emiko Shindo, Natsuki Fujio, Sei Muraoka, Makoto Kaburaki, Nahoko Tanaka, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki, Tomoko Hasunuma and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan

    Background/Purpose:  Glucocorticoids are widely used to treat a variety of diseases, including systemic autoimmune diseases. Although glucocorticoids improve the outcome for patients with these diseases,…
  • Abstract Number: 2256 • 2014 ACR/ARHP Annual Meeting

    Effects of Pre-Dosage Alendronate Treatment on Bone Metabolic Indices and Bone Mineral Density in Patients Treated with Glucocorticoids: A Prospective Study

    Yasuo Kuroki1, Hiroshi Kaji2, Mika Yamauchi3 and Toshitsugu Sugimoto4, 1Dept of Internal Medicine, Kobe Century Memorial Hospital, Kobe, Japan, 2Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osakasayama, Japan, 3Internal Medicine 1, Shimane University Faculty of Medicine, Izmo, Japan, 4Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan

    Background/Purpose: Glucocorticoids (GCs) treatment induces secondary osteoporosis characterized by rapid bone loss and an increase in fracture risk, although GCs are used to treat a…
  • Abstract Number: 2264 • 2014 ACR/ARHP Annual Meeting

    Denosumab for Long-Term Glucocorticoid Users Who Have Inadequate Response to the Bisphosphonates: A 12-Month Randomized Control Trial

    Chi Chiu Mok1, Ling Yin Ho1 and Kwok Man Ma2, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Nuclear Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong

    Background/Purpose To evaluate the efficacy of denosumab on bone mineral density (BMD) in long-term glucocorticoid users who have inadequate response to oral bisphosphonate treatment.Methods Patients…
  • Abstract Number: 1241 • 2013 ACR/ARHP Annual Meeting

    A Low Serum 25(OH) Vitamin D Level As a Risk Factor For Incidence and Severity Of Vertebral Fracture In Glucocorticoid-Induced Osteoporosis In Japan

    Mari Ushikubo1, Harumi Kuda1, Sayaka Kubo1, Keisuke Izumi2, Kumiko Akiya1 and Hisaji Oshima1, 1Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, 2Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Although levels of serum 25(OH) vitamin D (25(OH)D) have been discussed for preventing osteoporotic fractures in primary osteoporosis, an importance of the levels has…
  • Abstract Number: 2059 • 2012 ACR/ARHP Annual Meeting

    The Efficacy of Clinical Guidelines in Promoting Co-Prescription of Bone Protection with Glucocorticoids Among Hospital Doctors Treating Inpatients

    Leonard C. Harty1, James Clare2, Dylan Finnerty2, Susan Van Der Kamp2, Fionnuala Kennedy3, Malachi McKenna4 and Oliver M. FitzGerald1, 1Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, 2Department of Rheumatology, St. Vincent's University Hospital, Dublin, Ireland, 3Pharmacy Department, St. Vincent's University Hospital, Dublin, Ireland, 4Department of Endocrinology & Metabolic Bone Disease, St. Vincent's University Hospital, Dublin, Ireland

    Background/Purpose:  Therapeutic glucocorticoids (GC) rapidly decrease bone mineral density, inducing a remodelling imbalance by promoting osteoclast differentiation and activation and by inhibiting oscteocytes. Current guidelines…
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