Abstracts tagged "glucocorticoids and osteoblasts"

Abstract Number: 24 • ACR/ARHP Annual Meeting 2012
The Negative Effects of Glucocorticoids On Bone Are Primarily Mediated by Genes Involved in Osteoblast Differentiation and Bone Remodelling
Katharina Blankenstein¹, Tara C. Brennan-Speranza¹, Karin Lyon¹, Colin R. Dunstan¹, Frank Buttgereit², Hong Zhou³ and Markus J. Seibel³, ¹ANZAC Research Institute, Concord, NSW, Bone Research Program, Sydney, Australia, ²Charité - Universitätsmedizin Berlin, Berlin, Germany, ³Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, Australia
Background/Purpose: Glucocorticoids are widely used as anti-inflammatory and immunosuppressive drug for the treatment of many inflammatory and auto-immune diseases. However, long-term and high-dose glucocorticoid treatment…