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Abstracts tagged "glomerulonephritis and toll-like receptors"

  • Abstract Number: 2060 • ACR/ARHP Annual Meeting 2016

    Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses

    FuNien Tsai1, Carla Cuda2, Harris R. Perlman3, Philip J. Homan4, Salina Dominguez2, Alexander Shaffer3, George Kenneth Haines III5 and Jack Hutcheson6, 1Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Medicine-Rheumatology, Northwestern University, Chicago, IL, 5Mount Sinai, New York, NY, 6UT Southwestern, Dallas, TX

    Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…

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