Abstracts tagged "glomerulonephritis and systemic lupus erythematosus (SLE)"

Abstract Number: 72 • 2019 ACR/ARP Annual Meeting
The Single-cell Transcriptomic Landscape of NZB/W Murine Lupus at Early and Late Stages of Disease
Paul Hoover¹, Tom Eisenhaure ², David Lieb ², Anne Davidson ³ and Nir Hacohen ², ¹Brigham and Women's Hospital, Boston, MA, ²Broad Institute, Cambridge, MA, ³Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Lupus nephritis is a complex and heterogeneous disease characterized by infiltrating immune cells in damaged kidney tissue. While mouse models have enabled mechanistic studies…
Abstract Number: 2085 • 2018 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Promotes Kidney Damage in Immune Complex –Mediated Glomerulonephritis
Anamaria Talpos-Caia^1,2, Vinh Nguyen^2,3, Alexandru Tatomir^3,4, Sun-sang Sung⁵, John Papadimitriou⁶, Sergei Atamas^2,3, Irina G. Luzina^2,3, Simona Rednic¹, Horea Rus^3,4 and Violeta Rus^2,3, ¹Rheumatology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, ²Medicine, Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ³Research Service, Veteran Affairs Medical Center, Baltimore, MD, ⁴Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁵Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁶Pathology, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Response Gene to Complement (RGC)-32 is a cell cycle regulator widely expressed in normal tissues including brain, kidney, spleen, thymus, multiple tumors and in…

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