Abstracts tagged "glomerulonephritis"

Abstract Number: 2625 • 2019 ACR/ARP Annual Meeting
Predictors of Advanced Chronic Kidney Disease in Patients with ANCA Vasculitis and Renal Involvement
Gelsomina Alle¹, John Jaramillo Gallego ², Marina Scolnik ³, Valeria Scaglioni ², Martin Brom ⁴, Carlos Varela ⁵, Gustavo Greloni ⁵ and Enrique Soriano ⁶, ¹Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ²Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Argentina, ³Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁴Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁵Nephrology Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Argentina, ⁶Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina
Background/Purpose: The aim of this study was to evaluate the predictors of advanced chronic kidney disease (ACKD) in patients with Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
Abstract Number: 2104 • 2018 ACR/ARHP Annual Meeting
Glomerular and Tubular Transcriptional Profiles Reveal Gene Clusters Specific for Different Stages of Glomerulonephritis in NZM2328 Mice
Hongyang Wang¹, Nick Geraci², Prathyusha Bachali², Brian Kegerreis³, Michelle Catalina², Erika Hubbard², Sun-sang Sung⁴, Felicia Gaskin⁵, Amrie Grammer², Peter Lipsky² and Shu Man Fu⁶, ¹Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, ²AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ³AMPELBioSolutions and RILITE Research Institute, Charlottesville, VA, ⁴Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia School of Medicine, Charlottesville, VA, ⁵Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, ⁶Department of Medicine, University of Virginia, Charlottesville, VA
Background/Purpose: NZM2328 mice spontaneously develop glomerulonephritis (GN) and females commonly progress to renal failure. Our previous study showed that acute GN (aGN) and chronic GN…
Abstract Number: 2698 • 2018 ACR/ARHP Annual Meeting
Renal Involvement in Mixed Connective Tissue Disease: A Single Center Experience
Eduardo Martín Nares¹, Silvia Eunice Ramírez Andrade², Luis Eduardo Morales Buenrostro², Norma Ofelia Uribe Uribe³, Laura R Cárdenas M³, Montserrat Reyes Macedo³ and Tatiana S. Rodriguez-Reyna¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Kidney injury in mixed connective tissue disease (MCTD) is an uncommon manifestation. Prevalence has been reported to be <4% in some cohorts. The frequency…
Abstract Number: 2948 • 2018 ACR/ARHP Annual Meeting
Deconstructing the in Situ Myeloid Cell Microenvironment in Human Lupus Nephritis Tissue
Paul Hoover^1,2, Tony Jones², Cianna Leatherwood³, Sushrut Waikar⁴, Karen Costenbader³ and Nir Hacohen⁵, ¹Division of Rheumatology, Allergy, Immunology, Brigham and Women's Hospital, Boston, MA, ²Broad Institute, Cambridge, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Renal, Brigham and Women's Hospital, Boston, MA, ⁵Harvard Medical School, Boston, MA
Background/Purpose: The cell-types and pathways driving lupus nephritis (LN) are incompletely understood. The Accelerating Medicine Partnership lupus network Pathway Exploration and Analysis in RenaL disease…
Abstract Number: 139 • 2017 ACR/ARHP Annual Meeting
No Effect of Tumor Necrosis Factor-a Inhibitors on Renal Function in Patients with Rheumatoid Arthritis from Kobio Registry from 2012 to 2016
Seong-Kyu Kim¹, Jung-Yoon Choe², Sung-Hoon Park³ and Hwajeong Lee², ¹Rheumatology, Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South), ²Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South), ³Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea, Republic of (South)
Background/Purpose: Renal disease is prevalent in patients with rheumatoid arthritis (RA), although the precise prevalence of RA has not been determined. Increased mortality in patients…
Abstract Number: 2573 • 2017 ACR/ARHP Annual Meeting
Lack of CD137-CD137 Ligand Signalling Aggravates Glomerulonephritis and Reduces the Survival of Lupus-Prone B6.MRLlpr Mice
Anselm Mak¹, Bhushan Dharmadhikari² and Herbert Schwarz², ¹Medicine, National University of Singapore, Singapore, Singapore, ²Physiology, National University of Singapore, Singapore, Singapore
Background/Purpose: Costimulatory molecules, which are expressed on leukocytes that facilitate their cross-talks via stimulatory and inhibitory signalling, play a potentially important role in the inflammatory…
Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting
SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling
Jim Oates^1,2, Diane L. Kamen³ and Joy N Jones Buie⁴, ¹Medical Service, Ralph H. Johnson VAMC, Charleston, SC, ²Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ⁴Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…
Abstract Number: 2882 • 2016 ACR/ARHP Annual Meeting
CD4+ T Helper Cells and Regulatory T Cells in Active Lupus Nephritis – an Imbalance Towards a Predominant Th1 Response?
Danilo Mesquita Jr.¹, Marcello Fabiano Franco², Gianna Mastroianni Kirsztajn¹, Luciana Aparecida Reis¹, Sandro Perazzio³, Fernanda Vieira Mesquita¹, Vanessa Ferreira¹, Luis E C Andrade⁴ and Alexandre W.S. Souza⁵, ¹Internal Medicine, Universidade Federal de São Paulo, São Paulo, Brazil, ²Pathology, Universidade Federal de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ⁴Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ⁵Universidade Federal de São Paulo, São Paulo, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the involvement of multiple organs and systems with aberrations in T cell response,…
Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting
Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis
Chelsea Corradetti¹, Neelakshi Jog², Michael Madaio³ and Roberto Caricchio⁴, ¹Temple University, Philadelphia, PA, ²Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine, Medical College of Georgia, Augusta, GA, ⁴Medicine, Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…
Abstract Number: 2846 • 2014 ACR/ARHP Annual Meeting
CaMK4 Inhibition Ameliorates the Development of Th17 Driven Inflammatory Diseases By Preventing Recruitment of IL-17 Producing Cells to Target Organs
Tomohiro Koga^1,2, Kotaro Otomo², Masayuki Mizui³, Nobuya Yoshida⁴, José C. Crispin², Atsushi Kawakami¹ and George C. Tsokos⁵, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-17 producing T helper (Th17) cells have been closely associated with the development of organ damage in inflammatory and autoimmune diseases. We have previously…
Abstract Number: 753 • 2013 ACR/ARHP Annual Meeting
Validation Of The New Histopathological Classification Of ANCA Glomerulonephritis and Its Association With Renal Outcomes In a Paediatric Population
Marinka Twilt¹, Damien Noone², Wesley Hayes², Paul Thorner³, Susanne M. Benseler⁴, Ronald M. Laxer⁴, Rulan Parekh² and Diane Hebert², ¹Pediatric Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Nephrology, The Hospital for Sick Children, Toronto, ON, Canada, ³Pathology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Anti-Neutrophil Cytoplasmic Antibody (ANCA) associated glomerulonephritides (ANCA GN) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and Churg-Strauss. A novel histopathologic classification for GPA…
Abstract Number: 754 • 2013 ACR/ARHP Annual Meeting
Outcome Of Kidney Transplantation In Paediatric Patients With ANCA Associated Glomerulonephritis: A Single-Center Experience
Marinka Twilt¹, Damien Noone², Wesley Hayes², Paul Thorner³, Susanne M. Benseler⁴, Ronald M. Laxer⁴, Rulan Parekh² and Diane Hebert², ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Nephrology, The Hospital for Sick Children, Toronto, ON, Canada, ³Pathology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Kidney transplant outcomes for paediatric patients with end stage kidney disease (ESKD) secondary to ANCA GN, particularly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis…

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