Abstracts tagged "GILZ"

Abstract Number: 61 • 2019 ACR/ARP Annual Meeting
Lyn-Deficient Murine Lupus Is Exacerbated by Glucocorticoid-Induced Leucine Zipper (GILZ) Deficiency
Champa Nataraja¹, Jacqueline Flynn ¹, Wendy Dankers ¹, James Harris ¹, Sarah Jones ¹ and Eric Morand ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Lyn-deficient mice develop hyperactive B cells, excess IL-6 production, and nephritis. Mice deficient in glucocorticoid-induced leucine zipper (GILZ), an intracellular protein involved in glucocorticoid…
Abstract Number: 1787 • 2019 ACR/ARP Annual Meeting
The Glucocorticoid-Induced Protein GILZ Represent a Checkpoint in the IFN Program in SLE
Eric Morand¹, Champa Nataraja ¹, Melissa Northcott ¹, Wendy Dankers ¹, Jacqueline Flynn ¹, Wendy Zhu ¹, Taylah Bennett ¹, Mehnaz Pervin ¹, Brendan Russ ¹, James Harris ¹ and Sarah Jones ¹, ¹Monash University, Melbourne, Victoria, Australia
Background/Purpose: Given the primacy of Type I interferon (IFN) pathways in SLE pathogenesis, and the near-ubiquity of glucocorticoid (GC) use in SLE treatment, clarifying the…

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