Abstract Number: 782 • 2014 ACR/ARHP Annual Meeting
Temporal Artery Microbiome in Giant Cell Arteritis
Background/Purpose: Whether infectious agents play a part in giant cell arteritis (GCA) remains controversial. We have performed the first microbiome study of snap-frozen temporal arteries,…Abstract Number: 2786 • 2014 ACR/ARHP Annual Meeting
Aortitis: Outcomes from a Cohort of 196 Patients
Background/Purpose: Idiopathic aortitis is a rare diagnosis that may occur in the context of a primary systemic vasculitis, as part of a systemic autoimmune disease,…Abstract Number: 780 • 2014 ACR/ARHP Annual Meeting
Novel Roles for Zyxin in the Pathogenesis of Giant Cell Arteritis
Background/Purpose �:The mechanisms of the blood vessel injury in giant cell arteritis (GCA), a systemic vasculitis characterized by inflammation of large- and medium-sized vessels, remain…Abstract Number: 2770 • 2014 ACR/ARHP Annual Meeting
Polymyalgia Rheumatica Relapse and “Silence” Large Vessel Vasculitis. Is There Any Association?
Background/Purpose Large Vessel Vasculitis (LVV) can present with heterogeneous clinical manifestations, which range from general symptoms (fever, loss of weight) to the classic symptoms of …Abstract Number: 776 • 2014 ACR/ARHP Annual Meeting
A Candidate Gene Approach Identifies IL33 as a Novel Genetic Risk Factor for GCA
Background/Purpose: IL-33, through binding to its receptor ST2 (suppression of tumorigenicity 2), encoded by the interleukin 1 receptor-like 1 (IL1RL1) gene, activates mast cells and…Abstract Number: 1956 • 2014 ACR/ARHP Annual Meeting
Increased IL-6 Production By Effector B Cells in Giant Cell Arteritis and Polymyalgia Rheumatica
Background/Purpose: The role of B cells in auto-immunity may extend beyond the production of auto-antibodies. B cells can influence T cell responses via antigen presentation…Abstract Number: 775 • 2014 ACR/ARHP Annual Meeting
HLA-DRB1 Alleles in Susceptibility to Giant Cell Arteritis: Literature Review and Meta-Analysis
Background/Purpose Giant cell arteritis (GCA) has been reported by many studies (but not all) to be associated with carriage of HLA-DRB1*04, with variable results relating to…Abstract Number: 884 • 2014 ACR/ARHP Annual Meeting
Interleukin 6 Does Not Upregulate Pro Inflammatory Cytokine Expression in an Ex-Vivo Model of Giant Cell Arteritis
Background/Purpose Interleukin 6 (IL 6) is postulated to play a role in the pathogenesis of Giant Cell Arteritis. Several studies have demonstrated increased circulating IL…Abstract Number: 778 • 2014 ACR/ARHP Annual Meeting
PTPN22 rs2476601 and Susceptibility to Biopsy Proven Giant Cell Arteritis (GCA) in an Australian Sample
Background/Purpose: The aetiology and genetic background of GCA remains unclear, although genetic susceptibility is known to play a role. Recently, an association with the minor,…Abstract Number: 880 • 2014 ACR/ARHP Annual Meeting
An Immunochip Study Confirms a Strong Contribution of HLA Class I and II Genes in the Susceptibility to Giant Cell Arteritis
Background/Purpose: Giant cell arteritis (GCA) is a chronic autoimmune vasculitis with an important genetic component. We aimed to identify relevant risk loci for GCA predisposition…Abstract Number: 779 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor 2 Agonism Induces Inflammation, Angiogenesis and Cell Migration in Giant Cell Arteritis
Background/Purpose Activation of dendritic cells (DCs) is one of the earliest inciting events in Giant Cell Arteritis (GCA). TLR 2 is expressed on DCs in…Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting
A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis
Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…Abstract Number: 777 • 2014 ACR/ARHP Annual Meeting
Influence of the IL17A Locus in Giant Cell Arteritis Susceptibility
Background/Purpose: A recent study has showed that the number of Th17 lymphocytes is significantly increased in patients with GCA, resulting in an imbalance between Th17…Abstract Number: 808 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Disease Activity in Vasculitis
Background/Purpose To identify circulating proteins that distinguish between active vasculitis and remission in giant cell arteritis (GCA), Takayasu's arteritis (TAK), polyarteritis nodosa (PAN) and eosinophilic…Abstract Number: 88 • 2014 ACR/ARHP Annual Meeting
Microbiomes of Inflammatory and Non-Inflammatory Thoracic Aortic Aneurysms
Background/Purpose: Aortitis may occur in the context of multifocal large and medium-sized vessel diseases such as giant cell arteritis (GCA) or Takayasu arteritis (TAK) and…
ACR Meeting Abstracts