Abstracts tagged "giant cell arteritis"

Abstract Number: 776 • 2014 ACR/ARHP Annual Meeting
A Candidate Gene Approach Identifies IL33 as a Novel Genetic Risk Factor for GCA
Ana Márquez¹, Roser Solans², José Hernández-Rodríguez³, Maria C. Cid⁴, Santos Castañeda⁵, Marc Ramentol⁶, Luis Rodriguez-Rodriguez⁷, Javier Narváez⁸, Ricardo Blanco⁹, Norberto Ortego-Centeno¹⁰, Øyvind Palm¹¹, Andreas P. Diamantopoulos¹², Niko Braun¹³, Frank Moosig¹⁴, Torsten Witte¹⁵, Lorenzo Beretta¹⁶, Claudio Lunardi¹⁷, Marco A. Cimmino¹⁸, Augusto Vaglio¹⁹, Carlo Salvarani²⁰, Miguel A. Gonzalez-Gay²¹ and Javier Martin²², ¹Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ²Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, ³Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036- Barcelona, Spain, ⁵Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain, ⁶Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ⁷Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁸Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ⁹Hospital Marques de Valdecilla, Santander, Spain, ¹⁰Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹¹Department of Rheumatology, Oslo University Hospital and University of Oslo, Oslo, Norway, ¹²Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ¹³Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ¹⁴Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, ¹⁵Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹⁶Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁷Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁸Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ¹⁹Unit of Nephrology, University Hospital of Parma, Parma, Italy, ²⁰Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ²¹Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, ²²Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain
Background/Purpose: IL-33, through binding to its receptor ST2 (suppression of tumorigenicity 2), encoded by the interleukin 1 receptor-like 1 (IL1RL1) gene, activates mast cells and…
Abstract Number: 1956 • 2014 ACR/ARHP Annual Meeting
Increased IL-6 Production By Effector B Cells in Giant Cell Arteritis and Polymyalgia Rheumatica
Kornelis S.M. van der Geest¹, Wayel H. Abdulahad², Gerda Horst³, Abraham Rutgers², Annemieke M.H. Boots⁴ and Elisabeth Brouwer⁵, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Hanzeplein 1, UMCG, Groningen, Netherlands
Background/Purpose: The role of B cells in auto-immunity may extend beyond the production of auto-antibodies. B cells can influence T cell responses via antigen presentation…
Abstract Number: 775 • 2014 ACR/ARHP Annual Meeting
HLA-DRB1 Alleles in Susceptibility to Giant Cell Arteritis: Literature Review and Meta-Analysis
Sarah Mackie¹, John Taylor¹, Lubna Shafi², Stephen Martin², Bhaskar Dasgupta³, Andrew Gough⁴, Michael Green⁵, Lesley Hordon⁶, Stephen Jarrett⁷, Colin T. Pease⁸, Jennifer Barrett¹, Richard Watts^9,10 and Ann W. Morgan², ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁴Department of Rheumatology, Harrogate and District Foundation Trust, Harrogate, United Kingdom, ⁵Department of Rheumatology, York Teaching Hospital NHS Foundation Trust, York, United Kingdom, ⁶Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Dewsbury, United Kingdom, ⁷Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Wakefield, United Kingdom, ⁸Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁹Rheumatology, Ipswich Hospitals NHS Trust, Ipswich, United Kingdom, ¹⁰Medicine, Norwich Medical School University of East Anglia, Norwich, United Kingdom
Background/Purpose Giant cell arteritis (GCA) has been reported by many studies (but not all) to be associated with carriage of HLA-DRB1*04, with variable results relating to…
Abstract Number: 884 • 2014 ACR/ARHP Annual Meeting
Interleukin 6 Does Not Upregulate Pro Inflammatory Cytokine Expression in an Ex-Vivo Model of Giant Cell Arteritis
Lorraine O'Neill¹, Jennifer McCormick², Wei Gao², Conor Murphy³, Geraldine M. McCarthy⁴, Douglas J. Veale⁵, Ursula Fearon² and Eamonn S. Molloy¹, ¹Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁴Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁵Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose Interleukin 6 (IL 6) is postulated to play a role in the pathogenesis of Giant Cell Arteritis. Several studies have demonstrated increased circulating IL…
Abstract Number: 778 • 2014 ACR/ARHP Annual Meeting
PTPN22 rs2476601 and Susceptibility to Biopsy Proven Giant Cell Arteritis (GCA) in an Australian Sample
Susan Lester¹, Alex Hewitt², Linda Bradbury³, Elisabeth De Smit⁴, Andrew Harrison⁵, Graeme Jones⁶, Geoffrey O. Littlejohn⁷, Tony R. Merriman⁸, Bain Shenstone⁹, Malcolm D. Smith¹⁰, Maureen Rischmueller¹¹, Matthew A. Brown¹² and Catherine L. Hill^13,14, ¹Rheumatology Unit, Queen Elizabeth Hospital, Woodville South, Australia, ²Lions Eye Institute, University of Western Australia, Perth, Australia, ³The University of Queensland, Brisbane, Australia, ⁴Centre for Eye Research, University of Melbourne, Melbourne, Australia, ⁵Medicine, University of Otago, Wellington, New Zealand, ⁶Menzies Research Institute Tasmania, University of Tasmania, HOBART, Australia, ⁷Rheumatology, Monash Medical Center, Melbourne, Australia, ⁸Department of Biochemistry, University of Otago, Dunedin, New Zealand, ⁹Concord Hospital, Sydney, Australia, ¹⁰Rheumatology Research Unit, Repatriation General Hospital, Adelaide SA, Australia, ¹¹Department of Rheumatology, The Queen Elizabeth Hospital, SA, Australia, ¹²University of Queensland Diamantina Institute, Brisbane, Australia, ¹³Discipline of Medicine, University of Adelaide, Adelaide, Australia, ¹⁴Rheumatology Unit, The Queen Elizabeth Hospital, Woodville, Australia
Background/Purpose: The aetiology and genetic background of GCA remains unclear, although genetic susceptibility is known to play a role. Recently, an association with the minor,…
Abstract Number: 880 • 2014 ACR/ARHP Annual Meeting
An Immunochip Study Confirms a Strong Contribution of HLA Class I and II Genes in the Susceptibility to Giant Cell Arteritis
Francisco David Carmona¹, Sarah Mackie², Jose Ezequiel Martin¹, John Taylor², Augusto Vaglio³, Lara Bossini-Castillo¹, Santos Castañeda⁴, Maria C. Cid⁵, José Hernández-Rodríguez⁶, Roser Solans⁷, Ricardo Blanco⁸, Lorenzo Beretta⁹, Claudio Lunardi¹⁰, Marco A. Cimmino¹¹, Cisca Wijmenga¹², Torsten Witte¹³, Julia Holle¹⁴, Frank Moosig¹⁴, Verena Schönau¹⁵, Andre Franke¹⁶, Øyvind Palm¹⁷, Andreas P. Diamantopoulos¹⁸, Benedicte A. Lie¹⁹, Simon Carette²⁰, David Cuthbertson²¹, Gary S. Hoffman²², Nader A. Khalidi²³, Curry L. Koening²⁴, Carol A. Langford²⁵, Carol McAlear²⁶, Larry Moreland²⁷, Paul A. Monach²⁸, Christian Pagnoux²⁰, Philip Seo²⁹, Antoine G. Sreih³⁰, Kenneth J. Warrington³¹, Steven R. Ytterberg³¹, Colin T. Pease³², Andrew Gough³³, Michael Green³⁴, Lesley Hordon³⁵, Stephen Jarrett³⁶, Richard Watts³⁷, Sarah Levy³⁸, Yusuf Patel³⁹, Sanjeet Kamath⁴⁰, Bhaskar Dasgupta⁴¹, Paul IW. de Bakker⁴², Bobby P.C. Koeleman⁴², Jennifer H. Barrett², Carlo Salvarani⁴³, Peter A. Merkel⁴⁴, Miguel A. Gonzalez-Gay⁸, Ann W. Morgan² and Javier Martin¹, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ³Unit of Nephrology, University Hospital of Parma, Parma, Italy, ⁴Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ⁵Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036- Barcelona, Spain, ⁶Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁷Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁸Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, ⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁰Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹¹Department of Internal Medicine, Academic Unit of Clinical Rheumatology, University of Genova, Genova, Italy, ¹²Department of Genetics, University Medical Hospital Groningen, University of Groningen, Groningen, Netherlands, ¹³Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ¹⁴Vasculitis Clinic, Klinikum Bad Bramstedt & University Hospital of Schleswig Holstein, Bad Bramstedt, Germany, ¹⁵Department of Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany, ¹⁶Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ¹⁷Department of Rheumatology, Oslo University Hospital and University of Oslo, Oslo, Norway, ¹⁸Department of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ¹⁹Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway, ²⁰Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ²¹Department of Biostatistics, University of South Florida, Tampa, FL, ²²Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ²³Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ²⁴Division of Rheumatology, University of Utah, Salt Lake City, UT, ²⁵Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ²⁶Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ²⁷Rheumatology & Clinical Immunology, Vasculitis Center, of University of Pittsburgh Medical Center, Pittsburgh, PA, ²⁸Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ²⁹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ³⁰Medicine/Division of Rheumatology, The University of Pennsylvania, Philadelphia, PA, ³¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ³²Department of Rheumatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³³Department of Rheumatology, Harrogate and District Foundation Trust, Harrogate, United Kingdom, ³⁴Department of Rheumatology, York Teaching Hospital NHS Foundation Trust, York, United Kingdom, ³⁵Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Dewsbury, United Kingdom, ³⁶Department of Rheumatology, Mid Yorkshire Hospitals NHS Trust, Wakefield, United Kingdom, ³⁷Department of Rheumatology, Ipswich Hospital NHS Trust, Ipswich, United Kingdom, ³⁸Department of Rheumatology, Croydon Health Service NHS Trust, Croydon, United Kingdom, ³⁹Department of Rheumatology, Hull and East Yorkshire NHS Trust, Hull East Yorkshire, United Kingdom, ⁴⁰Department of Rheumatology, Staffordshire and Stoke-on-Trent Partnership NHS Trust, Staffordshire, United Kingdom, ⁴¹Department of Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁴²Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ⁴³Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ⁴⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Giant cell arteritis (GCA) is a chronic autoimmune vasculitis with an important genetic component. We aimed to identify relevant risk loci for GCA predisposition…
Abstract Number: 779 • 2014 ACR/ARHP Annual Meeting
Toll-like Receptor 2 Agonism Induces Inflammation, Angiogenesis and Cell Migration in Giant Cell Arteritis
Lorraine O'Neill¹, Aoife Maher¹, Jennifer McCormick², Conor Murphy³, Geraldine M. McCarthy⁴, Douglas J. Veale⁵, Ursula Fearon² and Eamonn S. Molloy¹, ¹Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland, ⁴Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁵Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose Activation of dendritic cells (DCs) is one of the earliest inciting events in Giant Cell Arteritis (GCA). TLR 2 is expressed on DCs in…
Abstract Number: 882 • 2014 ACR/ARHP Annual Meeting
A Signature of microRNAs Overexpressed in Inflamed Temporal Arteries of Patients with Giant Cell Arteritis
Stefania Croci¹, Alessandro Zerbini¹, Luigi Boiardi², Francesco Muratore², Alessandra Bisagni³, Giulia Pazzola², Luca Cimino⁴, Antonio Moramarco⁴, Davide Nicoli⁵, Enrico Farnetti⁶, Bruno Casali⁶, Alberto Cavazza³, Maria Parmeggiani⁷ and Carlo Salvarani², ¹Clinical Immunology, Allergology and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Laboratory of Molecular Biology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁶Laboratory of Molecular Biology,, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁷Clinical Immunology, Allergology and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: MicroRNAs (miRNAs) are small, non-coding RNAs that suppress gene expression at post-transcriptional level. MiRNAs can regulate innate and adaptive immunity. Moreover, they have been…
Abstract Number: 777 • 2014 ACR/ARHP Annual Meeting
Influence of the IL17A Locus in Giant Cell Arteritis Susceptibility
Javier Martin¹, Ana Márquez², José Hernández-Rodríguez³, Maria C. Cid⁴, Roser Solans⁵, Santos Castañeda⁶, Inmaculada C. Morado⁷, Javier Narváez⁸, Victor M. Martinez-Taboada⁹, Norberto Ortego-Centeno¹⁰, Bernardo Sopeña¹¹, Jordi Monfort¹², Maria Jesus Garcia-Villanueva¹³, Luis Caminal-Montero¹⁴, Eugenio De Miguel¹⁵, Ricardo Blanco¹⁶, Øyvind Palm¹⁷, Øyvind Molberg¹⁸, Joerg Latus¹⁹, Niko Braun¹⁹, Frank Moosig²⁰, Torsten Witte²¹, Lorenzo Beretta²², Alessandro Santaniello²³, Giulia Pazzola²⁴, Luigi Boiardi²⁵, Carlo Salvarani²⁶ and Miguel A. Gonzalez-Gay⁹, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Instituto de Parasitologia y Biomedicina López-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ³Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036- Barcelona, Spain, ⁵Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁶Department of Rheumatology, Hospital de la Princesa, IIS-Princesa, Madrid, Spain, ⁷Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁸Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ⁹Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain, ¹⁰Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹¹Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ¹²Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ¹³Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹⁴Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹⁵Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ¹⁶Hospital Marques de Valdecilla, Santander, Spain, ¹⁷Department of Rheumatology, Oslo University Hospital and University of Oslo, Oslo, Norway, ¹⁸Department of Rheumatology, Oslo University Hospital Rikshospitalet, Oslo, Norway, ¹⁹Department of Internal Medicine, Division of Nephrology, Robert-Bosch-Hospital, Stuttgart, Germany, ²⁰Department of Clinical Immunology and Rheumatology, University of Luebeck, Bad Bramstedt, Germany, ²¹Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²²Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²³Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ²⁴Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²⁵Unita` Operativa di Reumatologia, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ²⁶Rheumatology Unit, Department of Internal Medicine, Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy
Background/Purpose: A recent study has showed that the number of Th17 lymphocytes is significantly increased in patients with GCA, resulting in an imbalance between Th17…
Abstract Number: 808 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Disease Activity in Vasculitis
Alicia Rodriguez-Pla¹, Roscoe L. Warner², David Cuthbertson³, Simon Carette⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L Koening⁷, Carol A. Langford⁸, Kathleen Maksimowicz-McKinnon⁹, Larry W. Moreland¹⁰, Christian Pagnoux⁴, Philip Seo¹¹, Ulrich Specks^12,13, Kenneth J. Warrington¹⁴, Steven R. Ytterberg¹⁵, Peter A. Merkel¹⁶, Kent J. Johnson², Paul A. Monach¹⁷ and For the Vasculitis Research Consortium¹⁸, ¹Rheumatology, Boston University, Boston, MA, ²Pathology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, University of South Florida, Tampa, FL, ⁴Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁶Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁷Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, ⁸Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁹Rheumatology, Henry Ford Hospital, Detroit, MI, ¹⁰Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Frederichs Dr NW, Mayo Clinic, Rochester, MN, ¹³Mayo Clinic, Rochester, MN, ¹⁴Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹⁵Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁶University of Pennsylvania, Philadelphia, PA, ¹⁷Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ¹⁸U Pennsylvania, Philadelphia, PA
Background/Purpose To identify circulating proteins that distinguish between active vasculitis and remission in giant cell arteritis (GCA), Takayasu's arteritis (TAK), polyarteritis nodosa (PAN) and eosinophilic…
Abstract Number: 88 • 2014 ACR/ARHP Annual Meeting
Microbiomes of Inflammatory and Non-Inflammatory Thoracic Aortic Aneurysms
Pauline Funchain*^1,2,3, Gary S. Hoffman*⁴, Lars Svensson⁵, Eric Roselli⁵, Gosta Pettersson⁶, Douglas Johnston⁶, Edward Soltesz⁶, Ritu Chakravarti⁷, Alison Clifford⁸ and Charis Eng², ¹Genomic Medicine Institute, Lerner Research Institute, Cleveland, OH, ²Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, ³Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, ⁴Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁵Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁶Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁷Lerner Research Institure, Cleveland Clinic, Cleveland, OH, ⁸Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Aortitis may occur in the context of multifocal large and medium-sized vessel diseases such as giant cell arteritis (GCA) or Takayasu arteritis (TAK) and…
Abstract Number: 801 • 2014 ACR/ARHP Annual Meeting
Venothromboembolism in Large Vessel Vasculitis
Sankalp V. Bhavsar¹, Nader A. Khalidi², Simon Carette³, David Cuthbertson⁴, Peter C. Grayson⁵, Gary S. Hoffman⁶, Curry L. Koening⁷, Carol A. Langford⁸, Carol McAlear⁹, Larry Moreland¹⁰, Paul A. Monach¹¹, Christian Pagnoux³, Philip Seo¹², Kenneth J. Warrington¹³, Steven R. Ytterberg¹³ and Peter A. Merkel¹⁴, ¹Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ²Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, ³Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁴Department of Biostatistics, University of South Florida, Tampa, FL, ⁵NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, ⁶Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁷Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁹Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ¹⁰Vasculitis Center, of University of Pittsburgh Medical Center, Pittsburgh, PA, ¹¹Section of Rheumatology, Vasculitis Center, Boston University School of Medicine, Boston, MA, ¹²Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹³Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Venous thromboembolic disease (VTE) is a recognized characteristic of various systemic vasculitides, particularly small-vessel vasculitis. However, there are no reports describing the frequency of…
Abstract Number: 814 • 2014 ACR/ARHP Annual Meeting
Tocilizumab in Giant Cell Arteritis: Multicenter Open-Label Study of 22 Patients
Montserrat Santos-Gómez¹, Javier Loricera¹, Ricardo Blanco¹, Jose L. Hernández², Antonio Mera³, Eva Pérez-Pampin⁴, M. Enriqueta Peiró¹, Santos Castañeda-Sanz⁵, Alicia Humbría⁶, Jaime Calvo-Alen⁷, Elena Aurrecoechea⁸, Javier Narváez⁹, Amalia Sánchez-Andrade¹⁰, Paloma Vela¹¹, Elvira Díez Álvarez¹², Cristina Mata¹³, Pablo Lluch Mesquida¹⁴, Concepcion Moll Tuduri¹⁴, Vanesa Calvo-Río¹, Francisco Ortiz-Sanjuán¹, Trinitario Pina Murcia¹⁵, Carmen Gonzalez-Vela¹⁶, Leyre Riancho-Zarrabeitia¹ and Miguel A. González-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ²Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, ⁴Rheumatology, Hospital Clínico Universitario de Santiago de Compostela. Spain, Santiago de Compostela, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, ⁶Rheumatology, Hospital Universitario de La Princesa. IIS-Princesa, Madrid, Madrid, Spain, ⁷Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, ⁸Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, ⁹Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain, ¹⁰Rheumatology, Hospital Universitario Lucus Augusti. Lugo. Spain, Lugo, Spain, ¹¹Rheumatology, Hospital General de Alicante. Spain, Alicante, Spain, ¹²Rheumatology, Hospital de León. Spain, León, Spain, ¹³Rheumatology, Hospital Comarcal de Laredo. Spain, Laredo, Spain, ¹⁴Hospital Mateu Orfila. Menorca. Spain, Mahón (Menorca), Spain, ¹⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, ¹⁶Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose Giant cell arteritis (GCA) is a primary vasculitis that involves the aorta and its major branches. It usually affects people aged more than 50…
Abstract Number: 798 • 2014 ACR/ARHP Annual Meeting
Frequency and Predictive Variables of Relapses in Patients with Biopsy-Proven Giant Cell Arteritis
Luigi Boiardi¹, Giovanna Restuccia², Francesco Muratore¹, Alberto Cavazza³, Luca Cimino⁴, Raffaella Aldigeri⁵, Pierluigi Macchioni¹, Maria Grazia Catanoso⁶, Nicolò Pipitone¹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ²Rheumatology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁴Ophthalmology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical and experimental Medicine, Università di parma, Parma, Italy, ⁶Rheumatology Service, Arcispedale S Maria Nuova, Reggio Emilia, Italy
Background/Purpose: Giant cell arteritis (GCA) is a vasculitis that involves large and medium sized arteries in patients older than 50 years. Relapses and recurrences of…
Abstract Number: 794 • 2014 ACR/ARHP Annual Meeting
Color Doppler Ultrasonography Findings in Giant Cell Arteritis and Their Relationship with Clinical Manifestations
Cristina Ponte^1,2, Ruth Geraldes³, Anthea Craven¹, Andrew Judge⁴, Peter C. Grayson⁵, Ravi Suppiah⁶, Joanna Robson¹, Richard A. Watts⁷, Peter A. Merkel⁸ and Raashid Luqmani¹, ¹Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ²Rheumatology and Metabolic Bone Diseases Department, Rheumatology Research Unit - IMM, Lisbon Academic Medical Centre, Lisbon, Portugal, ³Neurology Department, Lisbon Academic Medical Centre, Lisbon, Portugal, ⁴Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁵NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD, ⁶Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁷Rheumatology Department Ipswich Hospital and University of East Anglia, Ipswich, United Kingdom, ⁸University of Pennsylvania, Philadelphia, PA
Background/Purpose Colour Doppler ultrasonography (CDU) of the temporal (TA), axillary (AA) and common carotid arteries (CA) has excellent sensitivity and specificity for the diagnosis of…

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