Abstracts tagged "Giant cell arteritis and interleukins (IL)"

Abstract Number: 1967 • 2015 ACR/ARHP Annual Meeting
Deregulation of Interleukin-22 Pathway in Giant Cell Arteritis
Stefania Croci¹, Alessandro Zerbini¹, Francesco Muratore², Lucia Belloni³, Francesco Ciccia⁴, Luigi Boiardi², Elena Simonazzi³, Alberto Cavazza⁵, Luca Cimino⁶, Antonio Moramarco⁶, Aroldo Rizzo⁷, Maria Parmeggiani⁸ and Carlo Salvarani^9,10, ¹Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ²Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ³Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁴Rheumatology Unit, University of Palermo, Palermo, Italy, ⁵Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Ophthalmology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁷Pathology Unit, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy, ⁸. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁹Rheumatology, Arcispedale S.Maria Nuova, Reggio Emilia, Italy, ¹⁰Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Interleukin-22 (IL-22) is produced by immune cells but acts only on non-hematopoietic cells, particularly at the barrier interface. We thus hypothesized that IL-22 pathway…

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