ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 1622 • ACR Convergence 2022

    TNF Receptor 1 Drives Murine Pulmonary Arterial Hypertension and Is Characterized by Loss of Capillary Endothelial Cells and Pericytes, Smooth Muscle Cell Proliferation, and Alterations in Fibroblast Phenotype

    Stacey Duemmel1, Marc Nuzzo1, Soumyaroop Bhattacharya1, Qingfu Xu1, Amy Mohan1 and Benjamin Korman2, 1URMC, Rochester, NY, 2University of Rochester, Rochester, NY

    Background/Purpose: We previously demonstrated that TNF-transgenic (TNF-Tg) mice have findings consistent with connective-tissue disease associated pulmonary arterial hypertension (CTD-PAH), and that this pathology is mediated…
  • Abstract Number: 0565 • ACR Convergence 2022

    Deciphering Complement System-dependent Cellular Pathways in Human Rheumatoid Arthritis Synovial Tissues Using Single-cell Computational Omics

    Juan Vargas1, Nirmal Banda2, Ian Mantel3, Anna Jonsson4, Kevin Wei5, Deepak Rao4, Susan Goodman6, Kevin D Deane7, Jennifer Seifert8, Jennifer Anolik9, Michael Brenner10, Soumya Raychaudhuri4, Accelerating Medicines Partnership RA/SLE4, Michael Holers2, Laura Donlin6 and Fan Zhang8, 1School Public Health Biostatistics Department, Aurora, CO, 2Department of Medicine Division of Rheumatology, Aurora, CO, 3Weill Cornell Medicine, New York, NY, 4Brigham and Women's Hospital, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Hospital for Special Surgery, New York, NY, 7University of Colorado Denver Anschutz Medical Campus, Denver, CO, 8University of Colorado, Aurora, CO, 9University of Rochester Medical Center, Rochester, NY, 10Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The complement system is a major component of innate immunity and plays a vital role in experimental models of autoimmune arthritis pathogenesis. In patients…
  • Abstract Number: 1663 • ACR Convergence 2022

    Age-Dependent Expansion and Activation of Disease-Associated Microglia in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde1, Caroline Shah1, Miranda Gurra1, Yidan Wang1, Deborah Winter2 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multipe end organs, including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 1105 • ACR Convergence 2021

    Discovering Variants in Suspected Monogenic Systemic Inflammatory Disease: An Adult Case Series

    Jason An1, Madeline Couse1, Dilan Dissanayake2, Daniela Dominguez2, Ronald Laxer1, Christian Marshall1, Johannes Roth3, Robert Rottapel4 and Linda Hiraki2, 1SickKids, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada, 4St Michael's Hospital, Toronto, ON, Canada

    Background/Purpose: Monogenic systemic inflammatory diseases (MSID) are a heterogeneous group of rare conditions caused by single gene variants leading to immune dysregulation. Diagnostic yield of…
  • Abstract Number: 1384 • ACR Convergence 2021

    A Genomic Meta-Analysis of Clinical Variables and Association with Intrinsic Molecular Subsets in Systemic Sclerosis

    Jennifer Franks1, Diana Toledo1, Viktor Martyanov1, Yue Wang2, Suiyuan Huang3, Tammara Wood1, Cathie Spino3, Robyn Domsic4, Monique Hinchcliff5, Dinesh Khanna3 and Michael Whitfield6, 1Geisel School of Medicine at Dartmouth, Hanover, NH, 2Geisel School of Medicine at Dartmouth, West Lebanon, NH, 3University of Michigan, Ann Arbor, MI, 4University of Pittsburgh, Pittsburgh, PA, 5Yale School of Medicine, Westport, CT, 6Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Four intrinsic molecular subsets (Inflammatory, Fibroproliferative, Limited, Normal-like) have been identified in systemic sclerosis (SSc) that may have different clinical associations. To test this…
  • Abstract Number: 1435 • ACR Convergence 2021

    Identification of Distinct Fibroblast Populations in Systemic Sclerosis 3D Skin Tissues with Single Cell Omics

    Noelle Kosarek1, Heetaek Yang2, Fred W. Kolling3, Tamar Abel4, Mengqi Huang5, Avi Smith6, Jonathan Garlick6, Patricia A. Pioli2 and Michael L. Whitfield7, 1Dartmouth Geisel School of Medicine, Hartford, VT, 2Geisel School of Medicine, Hanover, NH, 3Centers for Quantitative Biology, Hanover, 4Geisel School of Medicine, West Lebanon, NH, 5University of Pittsburgh, Pittsburgh, PA, 6Tufts University School of Dental Medicine, Boston, MA, 7Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by skin and internal organ fibrosis, vascular abnormalities, and autoantibody formation. Single cell genomics studies…
  • Abstract Number: 1512 • ACR Convergence 2021

    Epigenetic and Transcriptional Programs of CD4+ T Cell Anergy

    Philip Titcombe, Milagros Silva Morales and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 1927 • ACR Convergence 2021

    Heterogeneity of Juvenile Idiopathic Arthritis Synovial Fibroblasts Correlates to Disease Progression and Provides Compelling Diagnostic Data

    Megan Simonds1, Kathleen Sullivan2, Carlos Rose3 and AnneMarie Brescia4, 1Nemours, Wilmington, DE, 2The Children's Hospital of Philadelphia, Philadelphia, PA, 3Thomas Jefferson University/duPont Hospital for Children, Wilmington, DE, 4Nemours/A.I.duPont Hospital for Children, Wilmington, DE

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by…
  • Abstract Number: 1930 • ACR Convergence 2021

    Single-Cell Genomics Reveals a Shared Monocyte Interferon Program in a Subset of Patients with Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Lung Disease

    Emely Verweyen1, Kairavee Thakkar2, Kashish Chetal2, Sanjeev Dhakal3, Alexei Grom2, Nathan Salomonis2 and Grant Schulert2, 1Cincinnati Children's Hospital, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Cincinnati Children hospital, Cincinnati, OH

    Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is a clinically heterogenous disease and can be complicated by macrophage activation syndrome (MAS) and lung disease (LD) thought…
  • Abstract Number: 1935 • ACR Convergence 2021

    Skewed Escape from X-inactivation: Insights into the Female Bias of Sjögren’s Syndrome

    Teressa Shaw1, Wei Zhang2, Sara McCoy3, Xueer Qiu1, Adam Pagenkopf1, Robert Hal Scofield4, Jacques Galipeau3 and Yun Liang1, 1University of Wisconsin-Madison, Madison, WI, 2University of California San Diego, La Jolla, CA, 3University of Wisconsin, Madison, WI, 4Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Many autoimmune diseases feature increased prevalence in females, with primary Sjögren's syndrome (pSS) being the most female-predominant autoimmune disease with a female-to-male ratio of…
  • Abstract Number: 1938 • ACR Convergence 2021

    A Phenome-Wide Association Study of Genes Associated with COVID-19 Severity Reveals Shared Genetics with Rheumatic Conditions

    Anurag Verma1, Noah Tsao1, Lauren Thomann2, Yuk-Lam Ho2, Rotonya Carr1, Dana crawford3, Jimmy efird4, Jennifer Huffman2, Adriana Hung5, Kerry Ivey2, Sudha Iyengar3, Michael Levin6, Shiuh-Wen luoh7, Julie Lynch8, Pradeep Natarajan9, Saiju Pyarajan10, alexander Bick11, Lauren Costa2, Giulio Genovese12, Richard Hauger13, Ravi madduri14, Gita Pathak15, Renato polimanti15, Benjamin Voight1, Marijana Vujkovic1, Maryam Zekavat15, Hongyu Zhao15, Marylyn Ritchie1, Kyong-Mi Chang16, Kelly Cho2, Juan casas2, Phil Tsao17, J. Michael Gaziano2, Christopher ODonnell2, Scott Damrauer1 and Katherine Liao18, 1University of Pennsylvania, Philadelphia, PA, 2VA Boston Healthcare System, Boston, MA, 3Case Western Reserve University, Cleveland, OH, 4DVAHCS, Durham, 5Vanderbilt University Medical Center, Nashville, TN, 6University of Pennsylvania, Philadelphia, 7Oregon Health & Science University, Portland, 8VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, 9Massachusetts General Hospital, Boston, MA, 10Partners, Boston, 11Vanderbilt University, Nashville, TN, 12Harvard Medical School, Boston, MA, 13University of California San Diego, San Diego, CA, 14Argon National Lab, Chicago, IL, 15Yale University, New Haven, CT, 16VA Philadelphia, Philadelphia, PA, 17VA Palo Alto, Palo Alto, CA, 18Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Severe coronavirus disease 2019 (COVID-19) is associated with a broad range of clinical conditions. International efforts have led to the identification of risk alleles…
  • Abstract Number: 0008 • ACR Convergence 2021

    Jo-1-Binding and Clonally-Expanded Memory B Cells Express Germline and Somatically-Mutated B Cell Receptors in Anti-tRNA Synthetase Syndrome Patients

    Erin Wilfong, Alberto Cisneros, Jennifer Young-Glazer, Scott Smith, Leslie Crofford and Rachel Bonami, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Anti-tRNA synthetase syndrome (ARS) is a severe systemic autoimmune disease associated with myositis, interstitial lung disease, rash, and arthritis. ARS is associated with autoantibodies…
  • Abstract Number: 0472 • ACR Convergence 2021

    An Atlas of Human and Mouse Intrarenal Immune Cells in Lupus Nephritis Reveals Homologous Immune Populations Across Common Mouse Strains and Species

    Paul Hoover1, Michael Peters2, David Lieb2, Runci Wang3, Garett Dunlap4, Deepak Rao1, Nir Hacohen2 and Anne Davidson5, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Cambridge, MA, 3Brigham and Women’s Hospital, Boston, MA, 4Harvard University, Somerville, MA, 5Institute of Molecular Medicine, Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: We discovered 21 immune cell-types in lupus nephritis kidney biopsies as part of the Accelerating Medicines Partnership (AMP) consortium. These immune cells are the…
  • Abstract Number: 0500 • ACR Convergence 2021

    Clinical Phenotypes of Patients with Systemic Sclerosis with Distinct Molecular Signatures in the Skin

    Monica Yang1, Vivien Goh2, Monica Espinoza3, Yiwei Yuan4, Julia Lee5, Mary Carns6, Dinesh Khanna7, Zsuzsanna McMahan8, Michael Whitfield9 and Monique Hinchcliff10, 1University of California San Francisco, San Francisco, CA, 2Northwestern University, Chicago, IL, 3Geisel School of Medicine, Hanover, NH, 4Dartmouth College, Hanover, NH, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Northwestern University Division of Rheumatology, Chicago, IL, 7University of Michigan, Ann Arbor, MI, 8Johns Hopkins Rheumatology, Baltimore, MD, 9Geisel School of Medicine, Lebanon, NH, 10Yale School of Medicine, Westport, CT

    Background/Purpose: Although two subsets in systemic sclerosis (SSc) have been identified based on degree of skin disease, the current classification system, limited vs. diffuse cutaneous,…
  • Abstract Number: 0942 • ACR Convergence 2021

    Transcriptional Regulation of Synovial Macrophages in the Aging Joint

    Shang-Yang Chen1, Anna Montgomery1, Anna Woo1, Gaurav Gadhvi1, Harris Perlman1, Carla Cuda1, Dawn Bowdish2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2McMaster University, Hamilton, ON, Canada, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages are critical in maintaining tissue homeostasis, as well as in inflammation and immune response, but their function deteriorates with age increasing susceptibility to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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