ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 1678 • ACR Convergence 2022

    A Genome-Wide Association Analysis of 2,622,830 Individuals Reveals New Pathogenic Pathways in Gout

    Tony Merriman1, Hirotaka Matsuo2, Riku Takei3, Megan Leask3, Ruth Topless1, Yuya Shirai4, Zhiqiang Li5, Murray Cadzow1, Richard Reynolds3, kenneth saag3, Tayaza Fadason6, Justin O'Sullivan6, Nicola Dalbeth6, Lisa Stamp7, Abhishek Abhishek8, Michael Doherty8, Edward Roddy9, Lennart Jacobsson10, Meliha Kapetanovic11, Mariano Andrès12, Fernando Perez-Ruiz13, Rosa Torres Jimenez14, Timothy Radstake15, Timothy Jansen16, Matthijs Janssen17, Leo Joosten18, Tania Octavia Crisan19, Tom Huizinga20, Frederic LIOTE21, Pascal Richette22, Thomas Bardin23, Tristan Pascart24, Geraldine McCarthy25, Blanka Stiburkova26, Anne Tausche27, Till Uhlig28, Veronique Vitart29, Philip Riches29, Stuart Ralston29, Thomas MacDonald30, Akiyoshi Nakayama2, Masahiro Nakatochi31, Kimiyoshi Ichida32, Tappei Takada33, Chaeyoung Lee34, Matthew Brown35, Philip Robinson36, Catherine Hill37, Hyon Choi38, Nicholas Sumpter3, Marilyn Merriman3, Amanda Phipps-Green1, Wenhua Wei1, Sally McCormick1, Olle Melander39, René Toes20, Hang-Korng Ea21, Fina Kurreeman20, Laura Helbert25, Thibaud Boutin29, Nariyoshi Shinomiya2, Linda Bradbury40, Russell Buchanan41, Susan Lester37, Malcolm Smith42, Maureen Rischmueller43, On behalf of Japan Gout Genomics Consortium (J-Gout)44, On behalf of Japan Multi-Instl Collab Cohort Study (J-MICC)45, Eli Stahl46, Jeff Miner47, Daniel Solomon48, Jing Cui48, Kathleen Giacomini49, Deanna Brackman49, Eric Jorgenson50, On behalf of 23andMe Research Team51, Suyash Shringapure51, Alexander So52, Yukinori Okada4, Changgui Li5, Yongyong Shi53 and Tanya Major1, 1University of Otago, Dunedin, New Zealand, 2National Defense Medical College, Saitama, Japan, 3University of Alabama at Birmingham, Birmingham, AL, 4Osaka University, Suita, Osaka, Japan, 5The Affiliated Hospital of Qingdao University, Qingdao, China, 6University of Auckland, Auckland, New Zealand, 7University of Otago, Christchurch, New Zealand, 8University of Nottingham, Nottingham, United Kingdom, 9Keele University, Keele, United Kingdom, 10Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 11Lund University, Department for clinical sciences Lund, section of rheumatology and Lund University Hospital Lund and Malmö, Lund, Sweden, 12Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, 13University of the Basque Country, Barakaldo, Spain, 14La Paz University Hospital, Madrid, Spain, 15University Medical College Uthrecht, Utrecht, Netherlands, 16VieCuri Medical Centre, Venlo, Netherlands, 17Rijnstate Hospital, Bennekom, Netherlands, 18Radboudumc, Nijmegen, Netherlands, 19University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Cluj-Napoca, Romania, 20Leiden University Medical Center, Leiden, Netherlands, 21University of Paris, Paris, France, 22Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 23Hôpital Lariboisiere, Paris, France, 24Lille Catholic University, Lille, France, 25Mater Misericordiae University Hospital, Dublin, Ireland, 26Institute of Rheumatology, Prague, Czech Republic, 27University Clinic 'Carl Gustav Carus' at the Technical University, Dresden, Germany, 28Diakonhjemmet Hospital, Oslo, Norway, 29University of Edinburgh, Edinburgh, Scotland, United Kingdom, 30University of Dundee, Dundee, United Kingdom, 31Nagoya University Hospital, Nagoya, Japan, 32Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan, 33University of Tokyo Hospital, Tokyo, Japan, 34Soongsil University, Seoul, Republic of Korea, 35Genomics England, London, United Kingdom, 36University of Queensland, Brisbane, Australia, 37The Queen Elizabeth Hospital, Adelaide, Australia, 38Massachusetts General Hospital, Lexington, MA, 39Lund University, Malmö, Sweden, 40Gold Coast University Hospital, Brisbane, Australia, 41Austin Health, Heidelberg, Australia, 42Flinders Medical Centre, Adelaide, Australia, 43RheumatologySA, Adelaide, Australia, 44Japan Gout Genomics Consortium (J-Gout), Saitama, Japan, 45Japan Multi-Institutional Collaborative Cohort Study (J-MICC), Nagoya, Japan, 46Regeneron, New York, NY, 47ViscientBio, San Diego, CA, 48Brigham and Women's Hospital, Boston, MA, 49University of California San Francisco, San Francisco, CA, 50Kaiser Permanente, San Francisco, CA, 5123andMe, Inc., Sunnyvale, CA, 52University of Lausanne, Lausanne, Switzerland, 53Shanghai Jiao Tong University, Shanghai, China

    Background/Purpose: Genome-wide association studies (GWAS) in gout have been relatively small (≤13,179 people with gout) and have provided little insight into the progression from hyperuricemia…
  • Abstract Number: 0774 • ACR Convergence 2022

    HLA-DQ2 Is Associated with Anti-drug Antibody Formation to Infliximab Across Immune-mediated Inflammatory Diseases

    Marthe K. Brun1, Kristin Hammersbøen Bjørlykke2, Marte Kathrine Viken3, Grete-Elisabeth Stenvik1, Rolf Klaasen3, Johanna Elin Gehin3, David Warren3, Joe Sexton1, Espen Haavardsholm1, Jørgen Jahnsen2, Benedicte Alexandra Lie3, Nils Bolstad3, Kristin Kaasen Jørgensen2, Guro Løvik Goll1 and Silje Watterdal Syversen1, 1Diakonhjemmet Hospital, Oslo, Norway, 2Akershus University Hospital, Oslo, Norway, 3Oslo University Hospital, Oslo, Norway

    Background/Purpose: Immunogenicity is a leading cause of treatment failure to TNF inhibitors, and also affects drug safety. Variations in HLA class II genes have been…
  • Abstract Number: 1699 • ACR Convergence 2022

    Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations

    Yidan Wang1, Miranda Gurra1, Carla Cuda1, Hadijat Makinde1, Shangyang Chen1, Gaurav Gadhvi1, Salina Dominguez1, Caroline Shah1, Deborah Winter2 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of circulating monocytes – either classical or non-classical monocytes – is not…
  • Abstract Number: 0867 • ACR Convergence 2022

    Regulatory Haplotype of CXCR4 Is Associated with sJIA and Corelates with Enhanced Neutrophil and CD14+ Monocyte Migration

    Hiroto Nakano1, Emily Shuldiner2, Anne Hinks3, Marc Sudman4, Elaine Remmers5, Colleen Satorius6, Elizabeth Schmitz1, Victoria Arthur7, Patricia Woo8, Alexei Grom9, Dirk Foell10, John Bohnsack11, Marco Gattorno12, Seza Ozen13, Sampath Prahalad14, Rae Yeung15, Elizabeth Mellins2, Sheila Oliveira16, Jordi Antón17, Claudio Len18, Carol Lake19, Ly-Lan Bergeron20, Michelle Millwood21, Estefania de los santos21, Mariana Correia Marques22, Juvenile Arthritis Consortium for the Immunochip23, The Genomic Ascertainment Cohort Investigators24, INCHARGE Consortium25, Carl Langefeld26, Susan Thompson27, Wendy Thomson28 and Michael Ombrello1, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Stanford University, Stanford, CA, 3The University of Manchester, Manchester, United Kingdom, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5National Human Genome Research Institute, Bethesda, MD, 6NHGRI, NIH, Bethesda, MD, 7Boston Children's Hospital, Boston, MA, 8University College London, London, United Kingdom, 9Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 10University Hospital Münster, Münster, Germany, 11University of Utah, Salt Lake City, UT, 12Pediatric Clinic and Rheumatology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy, 13Hacettepe University Faculty of Medicine, Ankara, Turkey, 14Emory + Children's Pediatric Institute, Atlanta, GA, 15The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 16Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil, 17Pediatric Rheumatology Department. Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat, Spain, 18Universidade Federal de São Paulo, São Paulo, Brazil, 19NIH, Gaithersburg, MD, 20NIH/NIAMS, Vienna, VA, 21NIAMS, NIH, Bethesda, MD, 22National Institute of Arthritis and Musculoskeletal and Skin Diseases / Children`s National Hospital, Bethesda, MD, 23Juvenile Arthritis Consortium for the Immunochip, Bethesda, MD, 24The Genomic Ascertainment Cohort Investigators, Bethesda, MD, 25International Childhood Arthritis Genetics Consortium, Bethesda, MD, 26Wake Forest School of Medicine, Winston Salem, NC, 27Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Blue Ash, OH, 28Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a rare inflammatory disease that causes spiking fever, skin rash, chronic arthritis, and inflammation of the heart and…
  • Abstract Number: 1727 • ACR Convergence 2022

    BATF Represses BIM Expression to Sustain the T Cell Anergy Program

    Philip Titcombe, Milagros Silva-Morales, Na Zhang and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
  • Abstract Number: 1110 • ACR Convergence 2022

    Solving Sarcoidosis: A Transcriptome-based Meta-analysis of Clinical Sarcoidosis Studies Illustrates Shared Pathophysiology, Identifies Candidate Biomarkers and Suggests a Therapeutic Mechanism of JAK Inhibition

    Ingrid Lindquist1, James T. Rosenbaum2 and Marcia Friedman3, 1Oregon Health and Science University, Portland, OR, 2Legacy Devers Eye Institute, Portland, OR, 3Oregon Health and Science University, Division of Arthritis and Rheumatic Diseases, Portland, OR

    Background/Purpose: Sarcoidosis is a systemic, non-caseating granulomatous disease driven by a dysregulated immune response to environmental antigens. A wide range of clinical manifestations coupled with…
  • Abstract Number: 1731 • ACR Convergence 2022

    Systemic Sclerosis-Associated Class II HLA Alleles Restrict the Diversity of the CDR3 and the T Cell Receptor Repertoire in African American Patients

    Urvashi Kaundal1, Chloe Borden1, Cihan Oguz2, Jinghua Lu2, Emilee Stenson1, Ami Shah3, Maureen Mayes4, Ayo Doumatey5, Amy Bentley5, Daniel Shriner5, Robyn Domsic6, Thomas Medsger7, Paula Ramos8, Richard Silver8, Virginia Steen9, John Varga10, Vivien Hsu11, Lesley Ann Saketkoo12, Elena Schiopu13, Dinesh Khanna14, Jessica Gordon15, Lindsey Criswell16, Heather Gladue17, Chris Derk18, Elana Bernstein19, S. Louis Bridges, Jr.15, Victoria Shanmugam20, Lorinda Chung21, Suzanne Kafaja22, Reem Jan23, Marcin Trojanowski24, Avram Goldberg25, Benjamin Korman26, Settara Chandrasekharappa5, Faiza Naz27, Stefania Dell'Orso1, Adebowale Adeyemo5, Charles Rotimi5, Elaine Remmers5, Francesco Boin28, Fredrick Wigley29, Peter Sun2, Daniel Kastner5 and Pravitt Gourh30, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 3Johns Hopkins Rheumatology, Baltimore, MD, 4Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 5National Human Genome Research Institute, Bethesda, MD, 6University of Pittsburgh, Pittsburgh, PA, 7University of Pittsburgh School of Medicine, Pittsburgh, PA, 8Medical University of South Carolina, Charleston, SC, 9Georgetown University School of Medicine, Washington, DC, 10University of Michigan, Ann Arbor, MI, 11Rutgers-RWJ Medical School, South Plainfield, NJ, 12University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 13Michigan Medicine, Ann Arbor, MI, 14Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 15Hospital for Special Surgery, New York, NY, 16National Human Genome Research Institute, NIH, Bethesda, MD, 17Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 18University of Pennsylvania, Philadelphia, PA, 19Columbia University, New York, NY, 20George Washington University, Great Falls, VA, 21Stanford University, Stanford, CA, 22UCLA Department of Medicine, Division of Rheumatology, Los Angeles, CA, 23University of Chicago, Chicago, IL, 24Boston University School of Medicine, Boston, MA, 25NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 26University of Rochester, Rochester, NY, 27National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 28Cedars-Sinai Medical Center, Los Angeles, CA, 29Johns Hopkins University, Baltimore, MD, 30National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune, fibrotic disorder that disproportionately affects African Americans (AA). Previous work from our lab and others has suggested a…
  • Abstract Number: 1118 • ACR Convergence 2022

    Monocyte Transcriptomic Analysis Uncovers Heterogeneous Gene Expression Profiles in Systemic Lupus Erythematous (SLE) with and Without Subclinical Atherosclerosis

    Laurel Woodridge1, Elvira Chocano Navarro2, George Robinson1, Paul Ashford1, Kirsty Waddington3, Anisur Rahman4, Christine Orengo5, Ines Pineda-Torra6 and Elizabeth Jury1, 1University College London, London, United Kingdom, 2VIHR, Barcelona, Spain, 3University College London (alumni), London, United Kingdom, 4Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 5ISMB / UCL, London, United Kingdom, 6Cabimer, Sevilla, Spain

    Background/Purpose: A leading cause of mortality in SLE is cardiovascular disease (CVD) through accelerated atherosclerosis: the build-up of cells and lipids in the vascular wall.…
  • Abstract Number: 1734 • ACR Convergence 2022

    Identification of Sjögren’s Disease-Associated T Cell Receptors Through Deep Sequencing and Single-Cell Transcriptomics

    Ananth Aditya Jupudi1, Michelle Joachims1, Christina Lawrence1, Charmaine Lopez-Davis1, Bhuwan Khatri1, Astrid Rasmussen1, Lida Radfar2, Kiely Grundahl1, R. Hal Scofield2, Judith James1, Joel Guthridge1, Christopher Lessard1, Linda F. Thompson1 and A. Darise Farris1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren's disease (SjD) is a chronic rheumatic autoimmune disorder that primarily targets the lacrimal and salivary glands (SG) resulting in dry eyes and dry…
  • Abstract Number: 1119 • ACR Convergence 2022

    Investigating Macrophage Heterogeneity in the Esophagus and Lungs of SSc Patients

    Hadijat Makinde1, Carla Cuda1, Miranda Gurra1, Mary Carns2, Kathleen Aren2, Gaurav Gadhvi1, Salina Dominguez1, Jane Dematte3, Darren Brenner4, John Pandolfino5, G. R. Scott Budinger4, Deborah Winter6 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University Division of Rheumatology, Chicago, IL, 3Northwestern University, Elmhurst, IL, 4Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern University, Feinberg School of Medicine, Wilmette, IL, 6Northwestern University, Skokie, IL

    Background/Purpose: Our group has made important contributions to an emerging understanding of monocytes and macrophages as central to SSc pathogenesis. There are numerous studies that…
  • Abstract Number: 1851 • ACR Convergence 2022

    Phenotype and Genotype of Adult-onset Adenosine Deaminase 2 Deficiency Patients

    Beibei Zu1, rongrong wang2, Xiaorou Wang3, Bingqing Zhang4, Na Xu4, Chengjin Huang4, Min Shen5 and Xuejun Zeng4, 1Department of Rheumatology, Xuzhou Central Hospital, XuZhou, China, 2Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China, 3Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Beijing, China, 4Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 5Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease, characterized by early‑onset vasculopathy, fever, strokes, livedoid rash, hepatosplenomegaly, and hematologic dysfunction,…
  • Abstract Number: 1126 • ACR Convergence 2022

    Functional NOTCH4 Variants Increase Notch Signaling and Susceptibility for Systemic Sclerosis

    Urvashi Kaundal1, Emilee Stenson1, Mousumi Sahu1, Krishan Kumar Thakur1, Janet Wang1, Ami Shah2, Maureen Mayes3, Ayo Doumatey4, Amy Bentley4, Daniel Shriner4, Robyn Domsic5, Thomas Medsger6, Paula Ramos7, Richard Silver7, Virginia Steen8, John Varga9, Vivien Hsu10, Lesley Ann Saketkoo11, Elena Schiopu12, Dinesh Khanna13, Jessica Gordon14, Lindsey Criswell15, Heather Gladue16, Chris Derk17, Elana Bernstein18, S. Louis Bridges, Jr.14, Victoria Shanmugam19, Lorinda Chung20, Suzanne Kafaja21, Reem Jan22, Marcin Trojanowski23, Avram Goldberg24, Benjamin Korman25, Jim Mullikin4, Stefania Dell'Orso1, Adebowale Adeyemo4, Charles Rotimi4, Elaine Remmers4, Daniel Kastner4, Fredrick Wigley26, Francesco Boin27 and Pravitt Gourh28, 1National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Johns Hopkins Rheumatology, Baltimore, MD, 3Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX, 4National Human Genome Research Institute, Bethesda, MD, 5University of Pittsburgh, Pittsburgh, PA, 6University of Pittsburgh School of Medicine, Pittsburgh, PA, 7Medical University of South Carolina, Charleston, SC, 8Georgetown University School of Medicine, Washington, DC, 9University of Michigan, Ann Arbor, MI, 10Rutgers-RWJ Medical School, South Plainfield, NJ, 11University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 12Michigan Medicine, Ann Arbor, MI, 13Division of Rheumatology, Department of Internal Medicine, Scleroderma Program, University of Michigan, Ann Arbor, MI, 14Hospital for Special Surgery, New York, NY, 15National Human Genome Research Institute, NIH, Bethesda, MD, 16Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 17University of Pennsylvania, Philadelphia, PA, 18Columbia University, New York, NY, 19George Washington University, Great Falls, VA, 20Stanford University, Stanford, CA, 21UCLA Department of Medicine, Division of Rheumatology, Los Angeles, CA, 22University of Chicago, Chicago, IL, 23Boston University School of Medicine, Boston, MA, 24NYU Langone Medical Center - NYU Hospital for Joint Diseases, Lake Success, NY, 25University of Rochester, Rochester, NY, 26Johns Hopkins University, Baltimore, MD, 27Cedars-Sinai Medical Center, Los Angeles, CA, 28National Institutes of Health, Bethesda, MD

    Background/Purpose: Genome wide association studies (GWAS) in systemic sclerosis (SSc) have identified several genetic loci, but the search for the causal variant and gene continues.…
  • Abstract Number: 2164 • ACR Convergence 2022

    Profibrotic Alveolar Macrophages as a Potential Biomarker in Systemic Sclerosis-associated Interstitial Lung Disease

    Nikolay Markov1, Karolina Senkow1, Anthony Esposito2, Jonathan Puchalski3, Mridu Gulati3, Erica Herzog3, Danielle Antin-Ozerkis4, Mary Carns5, Alyssa Williams6, Nic Page6, Alexander Misharin1 and Monique Hinchcliff7, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Brigham and Women's Hospital, Department of Medicine, Boston, MA, 3Yale School of Medicine, New Haven, CT, 4Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, 5Northwestern University Division of Rheumatology, Chicago, IL, 6Yale University, New Haven, CT, 7Yale School of Medicine, Westport, CT

    Background/Purpose: Interstitial lung disease (ILD) is a leading cause of death in patients with systemic sclerosis (SSc). Previously, profibrotic monocyte-derived alveolar macrophages (MoAM) expressing (SPP1,…
  • Abstract Number: 0014 • ACR Convergence 2022

    The Expanded CD21 Low B Cell Subpopulation in Ankylosing Spondylitis Consists Mainly of Antigen-Inexperienced Cells

    Rick Wilbrink1, Linda van der Weele2, Anneke Spoorenberg1, Niek De Vries2, Frans Kroese1 and Gwenny Verstappen1, 1University Medical Center Groningen, Groningen, Netherlands, 2University Medical Center Amsterdam, Amsterdam, Netherlands

    Background/Purpose: The role of B cells in the pathogenesis of ankylosing spondylitis (AS) remains relatively understudied. Nevertheless, available evidence shows presence of B cells at…
  • Abstract Number: 1128 • ACR Convergence 2022

    The Causal Association Between Osteoarthritis and Common Comorbidities: A Mendelian Randomisation Study

    William Thompson1, Subhashisa Swain2, Sizheng Zhao3, Anne Kamps4, Carol Coupland5, Chang-Fu Kuo6, Michael Doherty5 and Weiya Zhang5, 1University of Nottingham, Exeter, United Kingdom, 2University of Oxford, Oxford, United Kingdom, 3The University of Manchester, Manchester, United Kingdom, 4Erasmus University Medical Centre, Rotterdam, Netherlands, 5University of Nottingham, Nottingham, United Kingdom, 6Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Background/Purpose: Osteoarthritis (OA) is the most common cause of joint pain and a major cause of disability. OA commonly associates with other conditions, such as…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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