ACR Meeting Abstracts

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Abstracts tagged "genomics"

  • Abstract Number: 1823 • ACR Convergence 2024

    Identification and Prediction of Systemic Sclerosis Intrinsic Subtypes Using Semi-Supervised and Supervised Learning on Gene Expression Data of Multiple Cohorts

    Zhiyun Gong1, Rezvan Parvizi2, Helen Jarnagin1, Haobin Chen3, Madeline Morrisson4, Tammara Wood5, Monique Hinchcliff6 and Michael Whitfield2, 1Dartmouth College, Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Hanover, NH, 3Dartmouth, Lebanon, NH, 4Geisel School of Medicine at Dartmouth College, Hanover, NH, 5Dartmouth, Hanover, NH, 6Yale School of Medicine, Westport, CT

    Background/Purpose: Systemic Sclerosis (SSc) is a molecularly heterogeneous disease. Distinct subtypes of patients have been identified based on gene expression in skin. In this study,…
  • Abstract Number: 0037 • ACR Convergence 2023

    New Histological Approach in Spatial Transcriptomics Implicates Glandular Cell Involvement in Pathophysiology of Sjögren’s Disease

    Paulina Czarnota1, Rick Wilbrink2, Bhuwan Khatri1, Anna Stolarczyk1, Cherilyn Pritchett Frazee1, Chuang Li1, Caleb Marlin1, Kyle Wright3, Kandice Tessneer1, Lida Radfar4, Judith James1, Robert Scofield1, Indra Adrianto5, Astrid Rasmussen1, Joel Guthridge1, A. Darise Farris1 and Christopher Lessard1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University Medical Center Groningen, Groningen, Netherlands, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4University of Oklahoma College of Dentistry, Oklahoma City, OK, 5Henry Ford Health, Detroit, MI

    Background/Purpose: 10X Visium spatial transcriptomics evaluates gene expression in a 50μm tile coordinate of a sectioned tissue, yielding heterogeneous cell sampling. Spatial PCA algorithm was…
  • Abstract Number: 1660 • ACR Convergence 2023

    Still’s Disease Patients with High Interferon-stimulated Gene Expression Have Enrichment of Rare, de Novo and Recessive Protein Altering Variants in Innate Immune Pathways

    Mariana Correia Marques1, Zuoming Deng2, Navid Chowdhury2, Elizabeth Schmitz3, Alana Platukus4, Stephen Brooks5, Carol Lake2, Ly-Lan Bergeron2, Michelle Millwood2 and Michael Ombrello6, 1National Institute of Arthritis & Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), St. Louis, MO, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Philadelphia, PA, 5Biodata Mining and Discovery Section, National Institute of Arthritis and Musculoskeletal and Skins Diseases, National Institutes of Health, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), North Bethesda, MD

    Background/Purpose: Still’s disease (systemic juvenile idiopathic arthritis in children, adult-onset Still’s disease in adults) is an enigmatic inflammatory condition that affects people of all ages.…
  • Abstract Number: 0039 • ACR Convergence 2023

    Enrichment of Rare Variants of Hemophagocytic Lymphohistiocytosis Genes in Systemic Juvenile Idiopathic Arthritis

    Mariana Correia Marques1, Danielle Rubin1, Emily Shuldiner2, Mallika Datta1, Elizabeth Schmitz1, Alexei Grom3, Dirk Foell4, Marco Gattorno5, John Bohnsack6, Rae Yeung7, Sampath Prahalad8, Elizabeth Mellins9, Jordi Anton Lopez10, Claudio Len11, Sheila Oliveira12, Patricia Woo13, Seza Ozen14, INCHARGE Consortium1, Zuoming Deng15 and Michael Ombrello1, 1National Institute of Arthritis & Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2Department of Biology, Stanford University, Stanford, CA, 3Division of Rheumatology, Cincinnati Children`s Hospital, Cincinnati, OH, 4University Hospital Münster, Münster, Germany, 5UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy, 6University of Utah, Salt Lake City, UT, 7The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, 8Emory University School of Medicine, Children's Pediatric Institute, Atlanta, GA, 9Stanford University, Stanford, CA, 10Pediatric Rheumatology Department, Hospital Sant Joan e Deu, Barcelona University, Barcelona, Spain, 11São Paulo Federal University, São Paulo, Brazil, 12Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil, 13University College London, London, United Kingdom, 14Hacettepe University Medical Faculty, Ankara, Turkey, 15National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a complex inflammatory condition of childhood. It can be complicated by macrophage activation syndrome (MAS), a secondary form…
  • Abstract Number: 1694 • ACR Convergence 2023

    Transcriptomic Analysis of the Impact of Iberdomide on Patients with SLE

    Prathyusha Bachali1, Shimon Korish2, Yanhua Hu3, Peter Schafer4, Amrie Grammer1 and Peter Lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2Bristol Myers Squibb, Summit, NJ, 3Bristol Myers Squibb, Princeton, NJ, 4Bristol Myers Squibb, Belle Mead, NJ

    Background/Purpose: Iberdomide is a high affinity cereblon ligand that promotes ubiquitylation and proteasomal degradation of Ikaros (IKZF1) and Aiolos (IKZF3) transcription factors and, thereby altering…
  • Abstract Number: 0063 • ACR Convergence 2023

    Investigating Macrophage Repopulation in the Synovium

    Jessica Maciuch1, Yidan Wang2, Slim Fourati1, Harris Perlman1 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Northwestern University, Hanover Park, IL, 3Northwestern University, Skokie, IL

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints. Macrophages are a key mediator of pro-inflammatory signaling, contributing to…
  • Abstract Number: 1712 • ACR Convergence 2023

    Identification and Functional Characterization of Eight CANDLE/PRAAS Causing Proteasome Variants in Five Unrelated Patients

    Adriana Almeida de Jesus1, Jonas J. Papendorf2, Frederic Ebstein3, Sara Alehashemi4, Daniela Pioto5, Anna Kozlova6, Maria Teresa TErreri7, Anna Shcherbina6, Andre Rastegar8, Marta Rodrigues9, Renan Pereira10, Sophia Park11, Bin Lin12, Kat Uss11, Ana Flavia da Silva Pina5, FLAVIO SZTAJNBOK13, Sofia Torreggiani14, Jennifer Stoddard15, Julie Niemela15, Sergio Rosenzweig15, Adriana Fonseca16, Marietta De Guzman17, Nicole Micheloni5, Melissa Fraga5, Sandro Perazzio18, Raphaela Goldbach-Mansky19 and Elke Krueger2, 1NIAID, NIH, Bethesda, MD, 2Institut für Medizinische Biochemie und Molekularbiologie (IMBM), Universitätsmedizin Greifswald, Greifswald, Germany, 3Nantes Université, Nantes, France, 4NIH/NIAID/TADS, Clarksville, MD, 5Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil, 6Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia, 7UNIFESP, São Paulo, Brazil, 8NIH, Bethesda, MD, 9Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, 10Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, 11Translational Autoinflammatory Diseases Section, LCIM, NIAID, NIH, Bethesda, MD, 12Translational Autoinflammatory Diseases Section l LCIM, NIAID, NIH, Bethesda, MD, 13UFRJ/UERJ, São Paulo, Brazil, 14University of Maryland Baltimore, Baltimore, MD, 15Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, 16Instituto de Puericultura e Pediatria Martagao Gesteira / Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil, 17Baylor College of Medicine, Houston, TX, 18Universidade de Sao Paulo (Unifesp); Universidade de São Paulo (USP); Fleury Laboratories, São Paulo, Brazil, 19NIH/NIAID, Potomac, MD

    Background/Purpose: Mutations in genes coding for 20S proteasome subunits or proteasome assembly helpers cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures (CANDLE) or…
  • Abstract Number: 0278 • ACR Convergence 2023

    NOD2 Genotyping Landscape in Yao Syndrome

    Hafsa Nomani1, Ashmia Saif2, Frank Hwang1 and Qingping Yao1, 1Stony Brook University, Stony Brook, NY, 2Stony Brook University Hospital, Syosset, NY

    Background/Purpose: Yao syndrome (YAOS, OMIM 617321) is formerly designated NOD2-associated autoinflammatory disease. A spectrum of NOD2 mutations have been associated with this disease. This study…
  • Abstract Number: 1722 • ACR Convergence 2023

    Fate-mapping of Synovial Monocytes and Macrophages

    Yidan Wang1, Carla Cuda1, Deborah Winter2 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Synovial monocytes and macrophages are heterogenous populations. These populations play diverse roles in the development of arthritis in humans and mice. In recent years,…
  • Abstract Number: 0449 • ACR Convergence 2023

    Parsing Pathophysiology of Rheumatoid Arthritis-associated Lymphoproliferative Disorders via Whole RNA Transcriptome Analysis: Multi-center Study in Japan

    ATSUKO TSUJII1, KAZUKO SAKAI2, SHIRO OHSHIMA1, YUKIHIKO SAEKI1, MASATO YAGITA3, TOMOYA MIYAMURA4, Masao Katayama5, YASUSHI HIRAMATSU6, SHINJI HIGA7, FUMINORI HIRANO8, KENJI ICHIKAWA9, NORIYUKI CHIBA10, TAKAO SUGIYAMA11, ATSUSHI IHATA12, HIROSHI TSUTANI13, KOICHIRO TAKAHI14, KIYOSHI MIGITA15, SHUNSUKE MORI16, NORIE YOSHIKAWA17, ATSUHISA UEDA18, SHOUHEI NAGAOKA19, KEIGO SETOGUCHI20, SHOJI SUGII21, ASAMI ABE22, TOSHIAKI SUGAYA23, HIROYUKI SUGAHARA24, SHINICHIRO TSUNODA24, NORISHIGE IIZUKA25, RYOSUKE YOSHIHARA26, HIROKI YABE27, TOMOAKI FUJISAKI28, EIICHI MORII29, KAZUYOSHI SAITO30, Kiyoshi Matsui31, YASUHIKO TOMITA32, HIROSHI FURUKAWA33, Shigeto Tohma34, KAZUTO NISHIO2 and YOSHIHIKO HOSHIDA35, 1National Hospital Organization (NHO), Osaka Minami Medical Center, Kawachinagano, Japan, 2Kindai University School of Medicine Department of Genome Biology, Sayama, Japan, 3Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-kofukai, Osaka, Japan, 4NHO Kyushu Medical Center, Fukuoka, Japan, 5National Hospital Organization, Nagoya Medical Center, Nagoya, JP, Nagoya, Japan, 6Japanese Red Cross Society Himeji Hospital, Himeji, Japan, 7Daini Osaka Police Hospital, Osaka, Japan, 8NHO Asahikawa Medical Center, Asahikawa, Japan, 9Nissei hospital, Sapporo, Japan, 10NHO Morioka Medical Center, Morioka, Japan, 11NHO Shimoshizu Hospital, Yotsukaido, Japan, 12NHO Yokohama Medical Center, Yokohama, Japan, 13NHO Awara Hospital, Awara, Japan, 14NHO Osaka Toneyama Medical Center, Toyonaka, Japan, 15Department of Rheumatology Fukushima Medical University School of Medicine, Fukushima, Japan, 16NHO Kumamoto Saishun Medical Center, Koshi, Japan, 17NHO Miyakonojo Medical Center, Miyakonojo, Japan, 18Yokohama City University Medical Center, Yokohama, Japan, 19Yokohama Minami Kyosai Hospital, Yokohama, Japan, 20Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital / Tokyo Metropolitan Komagome Hospital, Tokyo, Japan, 21Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan, 22Niigata Rheumatic Center, Shibata, Japan, 23Fuchu Hospital, Izumi, Japan, 24Sumitomo Hospital, Osaka, Japan, 25Kishiwada City Hospital, Kishiwada, Japan, 26Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan, 27Ako Central Hospital, Ako, Japan, 28Matsuyama Red Cross Hospital, Matsuyama, Japan, 29Osaka University, Suita, Japan, 30University of Occupational and Environmental Health, Kitakyushu, Japan, 31Hyogo Medical University, Nishinomiya, Japan, 32International University of Health and Welfare, Otawara City, Japan, 33NHO Tokyo National Hospital, Kiyose, Japan, 34NHO Tokyo National Hospital, Dallas, TX, 35National Hospital Organization Osaka Minami Medical Center, Kawachinagano, Japan

    Background/Purpose: Lymphoproliferative disorders (LPD) in rheumatoid arthritis (RA) (RA-LPD) have unique pathophysiological features. More than half of the cases of RA-LPD undergo spontaneous regression after…
  • Abstract Number: 1759 • ACR Convergence 2023

    Runx1 Is a Key Transcription Factor That Drives Synovial Fibroblast Pathogenicity in Rheumatoid Arthritis

    Christopher Mahony1, Samuel Kemble2, Paulynn Chin1, Cesar Prada3, Annie Hackland1, Patricia Reis-Nisa1, Lucy-Jayne Marsh1, Peter Keane1, Constanze Bonifer1, Christopher Buckley4, Stevephen Sansom5, Mark Coles4 and Adam Croft1, 1University of Birmingham, Birmingham, United Kingdom, 2University Birmingham, Rugeley, United Kingdom, 3The Kennedy Institute, Oxford, United Kingdom, 4University of Oxford, Oxford, United Kingdom, 5Kennedy Institute of Rheumatology, Oxford, United Kingdom

    Background/Purpose: Fibroblasts are key effector cells in rheumatoid arthritis (RA) underpinning joint inflammation and damage. Synovial tissue fibroblasts are heterogenous and acquire pathogenic cell states…
  • Abstract Number: 0014 • ACR Convergence 2023

    The 330 Genetic Risk Loci of Systemic Lupus Erythematosus (SLE) Now Known Are Consonant with Multiple Causal Mechanisms Involving Epstein-Barr Virus (EBV)-Encoded Transcription Co-factors (TFs) in EBV-Infected B Cells

    Viktoryia Laurynenka1, Xiaoting Chen2, sreeja Parameswaran2, Leah Kottyan2, Matthew Weirauch2, Iouri Chepelev3, Kenneth Kaufman3 and John Harley3, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Association of EBV infection with SLE, data suggesting an anti-EBNA1 molecular mimicry fostering SLE autoimmunity, and mechanisms in EBV infected B cells support a…
  • Abstract Number: 0600 • ACR Convergence 2023

    Identification of Subsets of SLE Patients Responsive to Baricitinib by Transcriptomic Analysis at Baseline

    Prathyusha Bachali1, Amrie Grammer2 and Peter Lipsky2, 1AMPEL BioSolutions, Redmond, WA, 2AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: Baricitinib is an inhibitor of Jak1 approved for treatment of rheumatoid arthritis, atopic dermatitis, alopecia areata and Covid-19. A phase 2 trial showed success…
  • Abstract Number: 1783 • ACR Convergence 2023

    Integrative Functional Genomics Points to Natural Killer Cells as Key Drivers in the Pathogenesis of Ankylosing Spondylitis

    Marcos Chiñas1, Daniela Fernandez-Salinas1, Vitor Aguiar1, Victor Caballero-Nieto2, Micah Lefton3, Joerg Ermann4 and Maria Gutierrez-Arcelus1, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Montpellier, France, 3Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a lymphocyte-driven disease. However, which lymphocyte populations are critical in AS pathogenesis is not…
  • Abstract Number: 0016 • ACR Convergence 2023

    Role of TP53 in Inflammatory Reprogramming of Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: TP53, a tumor-suppressor protein known as the guardian of the genome, plays a critical role in regulating genomic stability and cellular function. When TP53…
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